Uses for thyroid hormone compounds or thyroid hormone-like compounds
First Claim
1. A skin treatment composition for topical application, the composition comprising at least one thyroid hormone compound or thyroid hormone-like compound together with a pharmacologically acceptable base, wherein said thyroid hormone compound or thyroid hormone-like compound is a chemical entity which binds to TR-α
- or TR-β
with an equilibrium dissociation constant, Kd, lower than 1 μ
M, wherein
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Abstract
This invention relates to the use of topically applied thyroid hormone compounds and thyroid hormone-like compounds which are receptor binding ligands, either agonists or antagonists, to improve the appearance of the skin and underlying subcutaneous fat and improve certain medical conditions when applied topically. These compounds can be used to treat skin conditions such as stria, cellulite, roughened skin, actinic skin damage, intrinsically aged skin, photodamaged kin, lichen planus, ichthyosis, acne, psoriasis, wrinkled skin, corticosteroid atrophy, collagen deficient skin, and to diminish the size and improve the appearance of skin scarring from surgical or naturally occurring wounds, and to reduce the incidence of hyperkeratotic scarring. The thyroid agonists and antagonists may also promote differentiation and amelioration of dedifferentiated skin in premalignant lesions. The thyroid agonists and antagonists can be active in all organisms which contain the thyroid hormone receptors, notably amphibians, birds and subjects. Combination with Vitamin D analogs, glucocorticoids, and retinoids will potentiate and modify the effects of the thyroid hormones for increased benefit. Side effects of thyroid hormones which occur when the hormone is given orally and prevent usefulness for the above conditions are prevented when the hormone is topically applied.
67 Citations
25 Claims
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1. A skin treatment composition for topical application, the composition comprising at least one thyroid hormone compound or thyroid hormone-like compound together with a pharmacologically acceptable base, wherein said thyroid hormone compound or thyroid hormone-like compound is a chemical entity which binds to TR-α
- or TR-β
with an equilibrium dissociation constant, Kd, lower than 1 μ
M, wherein - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 23)
- or TR-β
-
22. A method of modulating the expression of genes in the skin, the method comprising applying a composition comprising at least one thyroid hormone compound or said thyroid hormone-like compound together with a pharmacologically acceptable base to the skin, wherein said thyroid hormone compound or said thyroid hormone-like compound is a chemical entity which binds to TR-α
- or TR-β
with a dissociation constant, Kd, lower than 1 μ
M.
- or TR-β
-
24. A method of reducing subcutaneous fat deposits in a subject, the method comprising the steps of applying a composition to skin of the subject, said composition comprising at least one thyroid hormone compound or thyroid hormone-like compound together with a pharmacologically acceptable base, wherein said thyroid hormone compound or thyroid hormone-like compound is a chemical entity which binds to TR-α
- or TR-β
with an equilibrium dissociation constant, Kd, lower than 1 μ
M, wherein - View Dependent Claims (25)
- or TR-β
Specification