Irradiation dose calculation unit, irradiation dose calculation method and recording medium

• US 6,222,905 B1
• Filed: 07/09/1999
• Issued: 04/24/2001
• Est. Priority Date: 08/27/1998
• Status: Expired due to Fees

• Current Assignee: Mitsubishi Denki Kabushiki Kaisha (Mitsubishi Electric Corporation)
• Original Assignee: Mitsubishi Denki Kabushiki Kaisha (Mitsubishi Electric Corporation)
• Inventors: Yoda, Kiyoshi, Kanematsu, Nobuyuki
• Primary Examiner(s): BRUCE, DAVID VERNON
• Application Number:
  US09/349,459
• Time in Patent Office: 655 Days
• Field of Search: 378/64, 378/65
• US Class Current: 378/65
• CPC Class Codes: A61N 5/1031 using a specific method of dose optimization

Abstract

An irradiation dose calculating unit can solve a problem of a conventional irradiation dose calculating unit in that since irradiation doses from portals are empirically determined, it is likely that optimum irradiation doses are not established for a target and a critical organ. A prescription data input section is used for a physician to input prescription data designating doses to a target and a critical organ. First and second object function calculating sections each calculate predefined indices, and obtain a first object function representing the level of satisfaction for the critical organ and a second object function representing the level of satisfaction for the target and critical organ. The irradiation doses from the portals are calculated based on these object functions such that the prescription data are satisfied.

Claims

1. An irradiation dose calculating unit comprising:

a prescription data input section for receiving prescription data including a prescription dose, a minimum dose, a maximum dose, and an underdose volume fraction for at least one target, and a limiting dose, a maximum dose, and an overdose volume fraction for at least one critical organ;

an absorbed dose distribution calculating section for calculating absorbed dose distributions of radiation beams irradiated from a plurality of portals to the target;

a first object function calculating section for calculating a first object function from the prescription data, irradiation dose ratios of the radiation beams irradiated from the portals to the target, and the absorbed dose distributions calculated by said absorbed dose distribution calculating section, the first object function indicating a level of satisfaction of the prescription data for the critical organ;

an irradiation dose ratio calculating section for calculating the irradiation dose ratios that optimize the first object function;

a second object function calculating section for calculating a second object function from the prescription data and a product of a scaling parameter multiplied by a sum of products obtained by multiplying the absorbed dose distributions for the portals by the irradiated dose ratios for the portals calculated by said irradiation dose ratio calculating section, the second object function indicating a level of satisfaction of the prescription data for the target and the critical organ;

a scaling parameter calculating section for calculating the scaling parameter that optimizes the second object function; and

an irradiation dose determining section for determining the irradiation doses from the portals from at least the scaling parameter calculated by said scaling parameter calculating section, the irradiation dose ratios for the portals calculated by said irradiation dose ratio calculating section, and the absorbed does distributions for the portals.

2. The irradiation dose calculating unit according to claim 1, wherein the absorbed dose distributions are normalized distributions obtained by dividing the absorbed dose distributions of the radiation beams irradiated from the portals to the target by an absorbed dose at reference coordinates in the target.

3. The irradiation dose calculating unit according to claim 1, wherein said first object function calculating section determines one of a first index and a second index as the first object function, the first index being calculated using a maximum value of the absorbed dose distributions in the critical organ, and the second index being calculated using a volume fraction of the critical organ, in which the absorbed dose is at least equal to a threshold absorbed dose.

4. The irradiation dose calculating unit according to claim 1, wherein said irradiation dose ratio calculating section determines the irradiation dose ratios for the portals by varying the irradiation dose ratios for the portals step-by-step from zero to one, by having said first object function calculating section calculate the first object function at each step, and by determining the irradiation dose ratios for the portals when the first object function is optimized.

5. The irradiation dose calculating unit according to claim 4, wherein said irradiation dose ratio calculating section determines the irradiation dose ratios only for portals with irradiation dose ratios less than unity.

6. The irradiation dose calculating unit according to claim 1, wherein said irradiation dose ratio calculating section calculates the irradiation dose ratios using an optimization method selected from a group consisting of an iterative search method, a simulated annealing method, a gradient method, and combinations of at least two of the iterative search method, the simulated annealing method, and the gradient method.

7. The irradiation dose calculating unit according to claim 1, wherein said second object function calculating section determines one of a first index, second index, third index, fourth index, and fifth index as the second object function, the first index being calculated using a maximum value in the critical organ of the product of the scaling parameter multiplied by the sum of products obtained by multiplying the absorbed dose distributions for the portals by the irradiated dose ratios for the portals calculated by said irradiation dose ratio calculating section, the second index being calculated using the overdose volume fraction of the critical organ in which the absorbed dose exceeds a threshold absorbed dose, the third index being calculated using a minimum value in the target of the product of the scaling parameter and the sum of the products, the fourth index being calculated using a maximum value in the target of the product of the scaling parameter and the sum of the products, and the fifth index being calculated using the volume fraction of the target in which the absorbed dose is less than the threshold absorbed dose.

8. The irradiation dose calculating unit according to claim 1, wherein said irradiation dose determining section places a product of the scaling parameter and the prescription dose for the target as an absorbed dose at the reference coordinates in the target, and determines the irradiation doses for the portals from the absorbed dose.

9. The irradiation dose calculating unit according to claim 8, wherein said irradiation dose determining section places the product of the scaling parameter and the prescription dose for the target as the absorbed dose of the reference coordinates in the target, obtains a proportionality constant by dividing the absorbed dose by the absorbed dose at the reference coordinates obtained from the sum of products of the absorbed dose ratios for the portals and absorbed doses for the portals per unit irradiation dose, and determines the irradiation doses of the portals by multiplying the irradiation dose ratios by the proportionality constant.

10. An irradiation dose calculating method comprising:

inputting prescription data including a prescription dose, a minimum dose, a maximum dose, and an underdose volume fraction for at least one target, and including a limiting dose, a maximum doses and an overdose volume fraction for at least one critical organ;

calculating absorbed dose distributions of radiation beams irradiated from a plurality of portals to the target;

calculating a first object function from the prescription data, irradiation dose ratios of the radiation beams irradiated from the portals to the target, and the absorbed dose distributions, the first object function indicating a level of satisfaction of the prescription data for the critical organ;

calculating the irradiation dose ratios that optimize the first object function;

calculating a second object function from the prescription data and a product of a scaling parameter multiplied by a sum of products obtained by multiplying the absorbed dose distributions for the portals by the irradiated dose ratios for the portals, the second object function indicating a level of satisfaction of the prescription data for the target and the critical organ;

calculating the scaling parameter that optimizes the second object function; and

determining the irradiation doses for the portals from at least the scaling parameter calculated, the irradiation dose ratios for the portals calculated, and the absorbed does distribution for the portals.

11. A computer usable medium having a computer readable program code means for causing a computer to function as an irradiation dose calculating unit comprising:

a prescription data input section for receiving prescription data including a prescription dose, a minimum dose, a maximum dose, and an underdose volume fraction for at least one target, and a limiting dose, a maximum dose, and an overdose volume fraction for at least one critical organ;

an absorbed dose distribution calculating section for calculating absorbed dose distributions of radiation beams irradiated from a plurality of portals to the target;

a first object function calculating section for calculating a first object function from the prescription data, irradiation dose ratios of the radiation beams irradiated from the portals to the target, and the absorbed dose distributions calculated by said absorbed dose distribution calculating section, the first object function indicating a level of satisfaction of the prescription data for the critical organ;

an irradiation dose ratio calculating section for calculating the irradiation dose ratios that optimize the first object function;

a second object function calculating section for calculating a second object function from the prescription data and a product of a scaling parameter multiplied by a sum of products obtained by multiplying the absorbed dose distributions for the portals by the irradiated dose ratios for the portals calculated by said irradiation dose ratio calculating section, the second object function indicating a level of satisfaction of the prescription data for the target and the critical organ;

a scaling parameter calculating section for calculating the scaling parameter that optimizes the second object function; and

an irradiation dose determining section for determining the irradiation doses from the portals from at least the scaling parameter calculated by said scaling parameter calculating section, the irradiation dose ratios for the portals calculated by said irradiation dose ratio calculating section, and the absorbed does distributions for the portals.