Method and device for tissue modulation
First Claim
1. A tissue modulation device comprising an upper surface and a lower surface, wherein the upper surface comprises a recessed region adjacent to a raised region, wherein the device is optically transparent through the upper and lower surfaces in the raised region, wherein the device further comprises an opaque raised region, and wherein the optically transparent region of the device is curved at the lower surface.
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Abstract
Disclosed is a tissue modulation device comprising an upper surface and a lower surface, wherein the upper surface comprises a recessed region adjacent to a raised region, wherein the device is optically transparent in at least one of the recessed region or the raised region, wherein application of a first portion of a tissue to the raised region depresses the first portion of the tissue relative to a second portion of the tissue that is in apposition to the recessed region, and wherein the optically transparent region of the device is curved at the lower surface to substantially reduce backscattered light in a light path traveling through the optically transparent region to a light collection system. Also disclosed is a method of noninvasive spectroscopic measurement of an analyte in a subject. The method comprises applying tissue of the subject to a tissue modulation device comprising a recessed region adjacent to a raised region so that the raised region depresses a first portion of tissue relative to a second portion of tissue in apposition to the recessed region; irradiating the tissue in a blood-replete state with electromagnetic radiation having an excitation wavelength; collecting the spectra emitted by the tissue in the blood-replete state; irradiating the tissue in a blood-depleted state with electromagnetic radiation having an excitation wavelength; collecting the spectra emitted by the tissue in the blood-depleted state; and analyzing the collected spectra to determine a concentration of analyte present in the tissue, wherein the analyzing comprises determining the difference between the spectra collected in the blood-replete and blood-depleted states.
141 Citations
42 Claims
- 1. A tissue modulation device comprising an upper surface and a lower surface, wherein the upper surface comprises a recessed region adjacent to a raised region, wherein the device is optically transparent through the upper and lower surfaces in the raised region, wherein the device further comprises an opaque raised region, and wherein the optically transparent region of the device is curved at the lower surface.
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29. A method of noninvasive spectroscopic measurement of an analyte in a subject comprising:
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(a) applying tissue of the subject to a tissue modulation device comprising a recessed region adjacent to a raised region so that the raised region depresses a first portion of tissue relative to a second portion of tissue in apposition to the recessed region, whereby a blood-depleted state is achieved in the first portion of tissue and a blood-replete state is achieved in the second portion of tissue;
(b) irradiating the tissue in a blood-depleted state with electromagnetic radiation having an excitation wavelength;
(c) collecting Raman spectra emitted by the tissue in the blood-depleted state;
(d) irradiating the tissue in a blood-replete state with electromagnetic radiation having an excitation wavelength;
(e) collecting Raman spectra emitted by the tissue in the blood-replete state; and
(f) analyzing the collected Raman to determine a concentration of analyte present in the tissue, wherein the analyzing comprises determining the difference between Raman spectra collected in the blood-replete and blood-depleted states. - View Dependent Claims (30, 31, 32, 33, 34, 35)
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36. A tissue modulation device comprising an upper surface and a lower surface, wherein the upper surface comprises a recessed region adjacent to a raised region, wherein the device is optically transparent through the upper and lower surfaces in the raised region, and wherein the optically transparent region of the device is curved at the lower surface, and the optically transparent region further comprises an optical filter.
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37. A tissue modulation device comprising an upper surface and a lower surface, wherein the upper surface comprises a recessed region adjacent to a raised region, wherein the device is optically transparent through the upper and lower surfaces in the raised region, wherein the optically transparent region of the device is curved at the lower surface, and the optically transparent region comprises a lens, and wherein the device further comprises a laser light source optically coupled with the lens, wherein the lens is capable of focusing light emitted by the laser onto the tissue.
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38. A tissue modulation device comprising an upper surface and a lower surface, wherein the upper surface comprises a recessed region adjacent to a raised region, wherein the device is optically transparent through the upper and lower surfaces in the raised region, wherein the optically transparent region of the device is curved at the lower surface, and the optically transparent region comprises a lens, and wherein the device further comprises a laser light source optically coupled with the lens, wherein the upper surface comprises a plurality of raised regions of differing heights.
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39. A tissue modulation device comprising an upper surface and a lower surface, wherein the upper surface comprises a recessed region adjacent to a raised region, wherein the device is optically transparent through the upper and lower surfaces in the raised region, wherein the optically transparent region of the device is curved at the lower surface, and wherein the device is optically coupled with a source of electromagnetic radiation and with a light detector.
- 40. A tissue modulation device comprising an upper surface and a lower surface, wherein the upper surface comprises a recessed region adjacent to a raised region, wherein the device is optically transparent through the upper and lower surfaces in the raised region, wherein the optically transparent region of the device is curved at the lower surface, wherein the device further comprises a series of recessed plates and raised plates, wherein the recessed plates have an upper surface comprising at least one recessed region and the raised plates have an upper surface comprising at least one raised region, and wherein the recessed and raised plates are coupled with one another so as to form a continuous loop, and further comprising at least one rotatable sprocket engaged with the loop such that rotation of the sprocket effects rotation of the loop.
Specification