Method and apparatus for the assessment and display of variability in mechanical activity of the heart, and enhancement of ultrasound contrast imaging by variability analysis
First Claim
1. A system for assessment of mechanical variability of the heart, comprising:
- a processing unit for receiving and storing scanned ultrasonic images, physiologic signals and a user-control input;
ultrasonic means for providing said scanned ultrasonic images of the heart of a subject to said unit;
a physiologic sensor for providing said physiologic signal of the subject for gating said scanned ultrasonic images so that said images are tagged by a specific time within the cardiac cycle with reference to a physiologic reference point when they are received by said unit;
user means for providing said user-input for processing said gated ultrasonic image to achieve estimation of said variability of the mechanical activity of the heart; and
display means coupled to said processing unit for receiving and displaying said variability of the mechanical activity of the heart.
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Abstract
This invention is a method of evaluating the mechanical variability of the heart activity by assessment of the variability of cardiologic echo Doppler images, and of enhancing contrast ultrasound imaging by variability imaging of two-dimensional echo images through the application of finite memory, ECG gated or ungated processing of the acquired images. For cardiac imaging and blood perfusion studies of non-cardiac structures, the acquired images are time-gated by the cardiac cycle to account for cardiac deformation due to contraction, relaxing and filling. To compare blood perfusion characteristics in normal tissue and abnormal tissue, a non-gated version, or gating to another physiologic cycle (e.g. breathing) can be used. The gated scans are either recursive processed in real time or are recorded and processed off-line to get estimation of the mean image and the variability of the image. The resulting images of the mean and variance are displayed for user interpretation.
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Citations
40 Claims
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1. A system for assessment of mechanical variability of the heart, comprising:
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a processing unit for receiving and storing scanned ultrasonic images, physiologic signals and a user-control input;
ultrasonic means for providing said scanned ultrasonic images of the heart of a subject to said unit;
a physiologic sensor for providing said physiologic signal of the subject for gating said scanned ultrasonic images so that said images are tagged by a specific time within the cardiac cycle with reference to a physiologic reference point when they are received by said unit;
user means for providing said user-input for processing said gated ultrasonic image to achieve estimation of said variability of the mechanical activity of the heart; and
display means coupled to said processing unit for receiving and displaying said variability of the mechanical activity of the heart. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method of evaluating the variability of the mechanical activity of the heart comprising the steps of:
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detecting an ultrasonic image of the cardiac structure to be displayed;
gating said ultrasonic image with a physiologic signal so that each image is tagged with a specific time in cycle with reference to a physiological reference point;
processing images having the same time tag from several cardiac cycles to yield an estimation of the average image and of the variability of the images around said average;
said gating and said processing being performed on “
m”
different images that are acquired during a complete cycle of said physiologic signal, and are repeated with images of multiple cardiac cycles; and
displaying the resulting “
m”
averaged images and “
m”
variability images in their tagged times with reference to said physiologic reference point.- View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
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13. The method according to claim 12, wherein said step of displaying comprises displaying said variability image superimposed over the average image using a color coded scheme.
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14. The method according to claim 12, wherein said step of displaying comprises displaying said variability image superimposed over the average image using a contour plot.
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15. The method according to claim 12, wherein said variability is derived from the mean value of the images at a specific reference time and the mean of the squared value images at the same reference time.
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16. The method according to claim 12, wherein said physiologic signal is provided to said ultrasonic means to initiate a new scan.
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17. The method according to claim 12, wherein said variability is determined by a batch algorithm for off-line analysis.
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18. The method according to claim 12, wherein said variance image is superimposed over the averaged images in the form of a contour plot.
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19. The method according to claim 12, wherein said ultrasonic means is a two dimensional mode imaging system.
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20. The method according to claim 12, wherein said ultrasonic means is an m-mode or Doppler imaging system wherein columns of pixels are processed with previous columns of pixels at the same reference point of the physiologic signal.
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21. A system for enhancing contrast ultrasound imaging by variability analysis, comprising:
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a processing unit for receiving and storing scanned ultrasonic images, physiologic signals and a user-control input;
ultrasonic means for providing said scanned ultrasonic images of structures injected with contrast agents of a subject to said unit;
a physiologic sensor for providing said physiologic signal of the subject for gating said scanned ultrasonic images so that said images are tagged by a specific time within the cardiac cycle with reference to a physiologic reference point when they are received by said unit;
user means for providing said user-input for processing said gated ultrasonic image; and
display means coupled to said processing unit for receiving and displaying said variability of the scanned structure. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A method of enhancing ultrasound contrast imaging comprising the steps of:
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injecting a contrast agent into a vein;
detecting an ultrasonic image of the structure to be displayed;
gating said ultrasonic image with a physiologic signal so that each image is tagged with a specific time in cycle with reference to a physiological reference point;
processing images having the same time tag from several cardiac cycles to yield an estimation of the average image and of the variability of the images around said average;
said gating and said processing being performed on “
m”
different images that are acquired during a complete cycle of said physiologic signal, and are repeated with images of multiple cardiac cycles; and
displaying the resulting “
m”
averaged images and “
m”
variability images in their tagged times with reference to said physiologic reference point.- View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40)
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33. The method according to claim 32, wherein said step of displaying comprises displaying said variability image superimposed over the average image using a color coded scheme.
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34. The method according to claim 32, wherein said step of displaying comprises displaying said variability image superimposed over the average image using a contour plot.
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35. The method according to claim 32, wherein said variability is derived from the mean value of the images at a specific reference time and the mean of the squared value images at the same reference time.
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36. The method according to claim 32, wherein said physiologic signal is provided to said ultrasonic means to initiate a new scan.
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37. The method according to claim 32, wherein said variability is determined by a batch algorithm for off-line analysis.
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38. The method according to claim 32, wherein said variance image is superimposed over the averaged images in the form of a contour plot.
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39. The method according to claim 32, wherein said ultrasonic means is a two dimensional mode imaging system.
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40. The method according to claim 32, wherein said ultrasonic means is an m-mode or Doppler imagine system wherein columns of pixels are processed with previous columns of pixels at the same reference point of the physiologic signal.
Specification