Pharmaceutical preparation for treating blood coagulation disorders

• US 6,224,862 B1
• Filed: 03/08/2000
• Issued: 05/01/2001
• Est. Priority Date: 03/20/1996
• Status: Expired due to Term

• Current Assignee: Baxalta GmbH (Shire plc), Baxalta Incorporated (Shire plc)
• Original Assignee: Baxter AG (Baxter International Inc.)
• Inventors: Turecek, Peter, Eibl, Johann, Schwarz, Hans-Peter
• Primary Examiner(s): Weddington, Kevin E.
• Application Number:
  US09/521,219
• Time in Patent Office: 419 Days
• Field of Search: 424/94.64, 514/2
• US Class Current: 424/94.64
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 38/4833 Thrombin (3.4.21.5)
• CPC Class Codes: A61K 38/4846 Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
• CPC Class Codes: A61K 38/57 from animals; from humans A61K38/553, A61K38/556 take precedence
• CPC Class Codes: A61P 3/14 for calcium homeostasis vitamin D A61P3/02; parathyroid hormones A61P5/18; calcitonin A61P5/22; osteoporosis A61P19/10; bone metastasis A61P35/04
• CPC Class Codes: A61P 39/02 Antidotes
• CPC Class Codes: A61P 7/02 Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: A61P 7/04 Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
• CPC Class Codes: C07K 1/18 Ion-exchange chromatography
• CPC Class Codes: C07K 1/20 Partition-, reverse-phase or hydrophobic interaction chromatography
• CPC Class Codes: C07K 1/36 by a combination of two or more processes of different types
• CPC Class Codes: C07K 14/745 Blood coagulation or fibrinolysis factors
• CPC Class Codes: C12N 9/6429 Thrombin (3.4.21.5)
• CPC Class Codes: C12N 9/6432 Coagulation factor Xa (3.4.21.6)
• CPC Class Codes: C12N 9/647 Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
• CPC Class Codes: C12Y 304/21005 Thrombin (3.4.21.5)
• CPC Class Codes: C12Y 304/21006 Coagulation factor Xa (3.4.21.6)

Abstract

There is disclosed a pharmaceutical preparation for treating blood coagulation disorders which comprises purified prothrombinase factors, in particular purified prothrombin and optionally purified factor Xa as active component.

Claims

1. A pharmaceutical preparation to be used for treating patients suffering from blood coagulation disorders, said pharmaceutical preparation comprising

at least two coagulation factors, said coagulation factors being components of a prothrombinase or of a pro-prothrombinase and being free from phospholipids, and

a protein having primary hemostatic activity.

2. A pharmaceutical preparation as set forth in claim 1, wherein said protein having primary hemostatic activity is vWF.

3. A kit for treating patients suffering from blood coagulation disorders, comprising the components

a) a pharmaceutical preparation comprising at least two coagulation factors, said coagulation factors being components of a prothrombinase or of a pro-prothrombinase and being free from phospholipids, and

b) a protein having primary hemostatic activity.

4. A kit as set forth in claim 3, wherein said protein having primary hemostatic activity is vWF.