Composition

• US 6,224,872 B1
• Filed: 07/20/1998
• Issued: 05/01/2001
• Est. Priority Date: 07/31/1997
• Status: Expired due to Fees

• Current Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kaguku Kenkyujo
• Original Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kaguku Kenkyujo
• Inventors: Fukuda, Shigeharu, Shibuya, Takashi, Ario, Takeshi
• Primary Examiner(s): Lankford, Jr., Leon B.
• Application Number:
  US09/118,897
• Time in Patent Office: 1,016 Days
• Field of Search: 424/195.1, 514/233.5, 514/25
• US Class Current: 424/729
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 36/21 Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
• CPC Class Codes: A61K 36/48 Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
• CPC Class Codes: A61K 36/70 Polygonaceae (Buckwheat family), e.g. spineflower or dock
• CPC Class Codes: A61K 36/74 Rubiaceae (Madder family)
• CPC Class Codes: A61K 36/82 Theaceae (Tea family), e.g. camellia
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Abstract

A composition which comprises a flavonoid and a processed product of a plant of the genus Pfaffia. The composition effectively maintains and promotes the health, treats and prevents diseases, and exerts immunoenhancement, antiallergic, psychotropic, and/or tonic activities.

Claims

1. A composition which comprises a flavonoid and a processed product of a plant of the genus Pfaffia, said flavonoid being a member selected from the group consisting of hesperidin, rutin, naringin, eriodictin, hesperetin, quercetin, naringenin, eriodictyol, enzyme-treated hesperidin, enzyme-treated rutin, enzyme-treated naringin, and enzyme-treated eriodictin;

said processed product being obtained by physically and/or chemically treating said plant;

wherein the amount of said flavonoid is in an amount of 0.001-1-fold of said processed product, on a dry solid basis;

said composition providing immunoenhancement and antiallergic activities compound with each of said flavonoid and said processed product.

2. The composition of claim 1, wherein said processed product is a minced, disrupted, ground, pulverized, pressed, fermented and/or extracted root of said plant.

3. The composition of claim 1, wherein said processed product is obtained by extracting the root of said plant with water and/or an alcohol.

4. The composition of claim 1, wherein said processed product contains ecdysterone and/or its derivative.

5. The composition of claim 4, which contains 0.0001-2 w/w % of said ecdysterone and/or its derivative, on a dry solid basis.

6. The composition of claim 1, which contains 0.01-20 w/w % of said flavonoid, on a dry solid basis.

7. The composition of claim 1, which contains a processed product of a caffeine-containing plant and/or a processed product of indican-containing plant in addition to said processed product of said plant of the genus Pfaffia.

8. The composition of claim 7, wherein said processed product of said caffeine-containing plant is a minced, disrupted, ground, pulverized, pressed, fermented and/or extracted seed of said plant;

and said processed product of said indican-containing plant is a minced, disrupted, ground, pulverized, pressed, fermented and/or extracted leaf and/or stem of said plant.

9. The composition of claim 8, wherein said extract of said caffeine-containing plant is obtained by extracting said seed with water and/or an alcohol, and said extract of said indican-containing plant is obtained by extracting said leaf and/or said stem with water and/or an alcohol.

10. The composition of claim 7, wherein said caffeine-containing plant is a plant of the genus Paullinia, Coffea, Thea sinensis, or Cola;

and said indican-containing plant is a plant of the genus Percicaria or Indigofera.

11. The composition of claims 10, wherein said caffeine-containing plant is Guarana of the genus Paullinia, and said indican-containing plant is an indigo plant of the genus Percicaria.

12. The composition of claim 7, which contains said processed product of said caffeine-containing product in an amount of 0.01-10-folds of said processed product of said plant of the genus Pfaffia.

13. The composition of claim 7, which contains said processed product of said indican-containing product in an amount of 0.0001-0.1-fold of said processed product of said plant of the genus Pfaffia.

14. The composition of claim 7, which contains 0.0001-4 w/w % caffeine and/or its derivative, on a dry solid basis.

15. The composition of claim 1, which contains a saccharide.

16. The composition of claim 15, wherein said saccharide is one or more members selected from the group consisting of trehalose, anhydrous crystalline trehalose, maltose, and anhydrous crystalline maltose.

17. The composition of claim 1, which is in the form of a liquid, solid, powder, semi-solid, paste or suspension.

18. The composition of claim 1, which is for an orally administrable composition.

19. The composition of claim 1, which is for an antasthenic.

20. The composition of claim 1, which is for an agent for immunoenhancement, antiallergic, psychotropic, and/or tonic.