Regulation of appetite, body weight and athletic function with materials derived from citrus varieties

• US 6,224,873 B1
• Filed: 08/31/1998
• Issued: 05/01/2001
• Est. Priority Date: 09/30/1996
• Status: Expired due to Term

• Current Assignee: Advantra Z, Inc. (Innophos Holdings Incorporated), The Trustees of The Stevens Institute of Technology (Stevens Institute Of Technology)
• Original Assignee: Zhishin, LLC
• Inventors: Jones, Dennis
• Primary Examiner(s): Weddington, Kevin E.
• Application Number:
  US09/142,197
• Time in Patent Office: 974 Days
• Field of Search: 424/195.1, 514/626, 514/909, 514/534, 514/535, 514/653, 514/789
• US Class Current: 424/736
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/00 Medicinal preparations containing organic active ingredients
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 31/137 Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
• CPC Class Codes: A61K 31/16 Amides, e.g. hydroxamic acids
• CPC Class Codes: A61K 31/24 having an amino or nitro group
• CPC Class Codes: A61K 36/75 Rutaceae (Rue family)
• CPC Class Codes: A61K 36/752 Citrus, e.g. lime, orange or lemon

Abstract

Materials derived from Citrus plants can be administered orally to humans for the purpose of producing or maintaining weight loss as well as for improving the person'"'"'s physical performance and increasing the person'"'"'s lean muscle mass. The Citrus materials include those portions of the plant that are normally considered waste or inedible, such as the leaves, peel, and immature, unripe fruit. The materials contain at least one of the alkaloids from the group consisting of synephrine, hordenine, octopamine, tyramine and N-methyltyramine (1). Two species, Citrus aurantium and Citrus reticulata, are particularly useful. The materials can be administered in their natural form or as extracts, and can be administered in various ways including capsules and tablets. The Citrus materials may also be used as a tea. For weight loss and weight control, the materials can be administered concurrently with caloric restriction or in the absence of caloric restriction. The materials may also be administered for the purpose of increasing muscle mass concurrently with a high protein diet as well as with an exercise program.

Claims

1. A method for stimulating thermogenesis in humans by administering by mouth to a subject a composition containing at least one of the substances selected from the group consisting of synephrine, hordenine, octopamine, tyramine and N-methyltyramine in therapeutically effective amounts.

2. The method according to claim 1 wherein the composition is a plant material containing at least one of said substances.

3. The method according to claim 2 wherein the amount of the substances is about three to four percent by weight which is effective to increase the metabolic rate of the subject without inducing increased caloric intake.

4. The method according to claim 1 wherein the dosage is at least 0.02 mg per kg of ideal weight which is effective to increase the metabolic rate of the subject without inducing increased caloric intake.

7. The method according to claim 2, wherein said plant material is a citrus material.

8. The method according to claim 7, wherein said citrus material is obtained from a species selected from the group consisting of Citrus reticulata, Citrus aurantium, Citrus medica, Citrus maxima, Citrus limon, Citrus aurantiufolia, Citrusparadisi, Citrus sinensis and Poncirus trifoliate.

5. A method for reducing the weight of a human, which comprises administering to the human a thermogenically effective dose of a plant material containing at least one of the substances selected from the group consisting of synephrine, hordenine, octopamine, tyramine and N-methyltyramine.

9. The method according to claim 5, wherein said plant material is a citrus material.

10. The method according to claim 9, wherein said citrus material is obtained from a species selected from the group consisting of Citrus reticulata, Citrus aurantium, Citrus medica, Citrus maxima, Citrus limon, Citrus aurantiifolia, Citrusparadisi, Citrus sinensis and Poncirus trifoliate.

6. A method for reducing the adipose tissue mass/lean mass body mass ratio of a human, which comprises administering to the human a thermogenically effective dose of a plant material containing at least one of the substances selected from the group consisting of synephrine, hordenine, octopamine, tyramine and N-methyltyramine.

11. The method according to claim 6, wherein said plant material is a citrus material.

12. The method according to claim 11, wherein said citrus material is obtained from a species selected from the group consisting of Citrus reticulata, Citrus aurantium, Citrus medica, Citrus maxima, Citrus limon, Citrus aurantuifolia, Citrusparadisi, Citrus sinensis and Poncirus trifoliate.