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Method for determining a nucleic acid

  • US 6,225,052 B1
  • Filed: 11/21/1997
  • Issued: 05/01/2001
  • Est. Priority Date: 02/24/1997
  • Status: Expired due to Fees
First Claim
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1. A method for determining a nucleic acid in a sample comprisingbinding to the nucleic acid a probe molecule having a polymeric backbone different from the natural sugar phosphate backbone via base mediated hydrogen bonding, wherein an electron acceptor or an electron donor or an electron acceptor and an electron donor is covalently bound to said probe molecule at a non-terminal subunit of said polymeric backbone not bearing a nucleobase, inducing an electron transfer from said electron donor or to said elector acceptor and determining the occurrence of the electronic transfer as a measure of said nucleic acid.

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