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Treatment of hearing impairments

  • US 6,225,282 B1
  • Filed: 01/02/1997
  • Issued: 05/01/2001
  • Est. Priority Date: 01/05/1996
  • Status: Expired due to Term
First Claim
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1. A method for treating a hearing impairment in a mammal, comprising administering to the mammal in need of such treatment a therapeutically effective amount of a trkB or trkC agonist to promote post-natal spiral ganglia neuron protection of survival, wherein the agonist is selected from the group consisting of a neurotrophin, a chimeric neurotrophin, and a pantropic neurotrophin binding to and activating a trkB or trkC receptor, and an antibody agonist of a trkB or trkC receptor or antigen-binding fragment thereof, and wherein the hearing impairment is ototoxin induced.

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