Low molecular weight dendritic compounds as pharmaceutical agents
First Claim
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1. A compound of formula or a pharmaceutically acceptable salt thereof wherein:
- A is selected from [1,2,3,5-tetrasubstituted or 1,2,4- or 1,3,5-trisubstituted benzene;
2,3,4,5-tetrasubstituted or 2,3,5;
or 2,4,5-trisubstituted thiophenes;
2,3,4,6- or 2,4,5,6-tetrasubstituted or 2,3,5-;
or 2,3,6-trisubstituted pyridine;
] 1,8,X-trisubstituted naphthalene, ortho-, meta-, or perisubstituted naphthalene;
B, C, and D are covalently bonded to A and are the same or different and are independently selected from —
Y—
Z—
below;
Y is selected from ═
(CH2)n—
O—
, O—
(CH2)n—
, —
NHCO(CH2)n, (CH2)nNHCO—
, CONH-(CH2)n, (CH2)nCONH;
—
(CH2)n—
, or a bond wherein n is an integer of from 0 to 3. Z is di, tri, or tetrasubstituted benzene as defined above or is selected from A above, or is a substituted amine or amide selected from —
CH2-3-indole and —
CH2-2-imidazole or a carbamate, or a bond;
E, F, G, H, I, J, K, L, and M are each independently selected from B, C, and D above;
X is hydrogen, (CH2)nCO2R wherein R is an ester;
N or a function group attached to the one monomer A above.
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Abstract
This invention is for low molecular weight dendritic polymers (dendroids) of Formula I
are useful as agents in the treatment of cancer, Alzheimers disease, thrombosis, inflammatory diseases, and bacterial resistance.
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Citations
4 Claims
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1. A compound of formula
or a pharmaceutically acceptable salt thereof wherein: -
A is selected from [1,2,3,5-tetrasubstituted or 1,2,4- or 1,3,5-trisubstituted benzene;
2,3,4,5-tetrasubstituted or 2,3,5;
or 2,4,5-trisubstituted thiophenes;
2,3,4,6- or 2,4,5,6-tetrasubstituted or 2,3,5-;
or 2,3,6-trisubstituted pyridine;
] 1,8,X-trisubstituted naphthalene, ortho-, meta-, or perisubstituted naphthalene;
B, C, and D are covalently bonded to A and are the same or different and are independently selected from —
Y—
Z—
below;
Y is selected from ═
(CH2)n—
O—
, O—
(CH2)n—
, —
NHCO(CH2)n, (CH2)nNHCO—
, CONH-(CH2)n, (CH2)nCONH;
—
(CH2)n—
, or a bond wherein n is an integer of from 0 to 3.Z is di, tri, or tetrasubstituted benzene as defined above or is selected from A above, or is a substituted amine or amide selected from —
CH2-3-indole and —
CH2-2-imidazole or a carbamate, or a bond;
E, F, G, H, I, J, K, L, and M are each independently selected from B, C, and D above;
X is hydrogen, (CH2)nCO2R wherein R is an ester;
N or a function group attached to the one monomer A above.- View Dependent Claims (2, 3, 4)
8-(4-Bromo-benzyloxy)-naphthalene-1-carboxylic acid dimethylamide;
8-(4-Methoxy-benzyloxy)-naphthalene-1-carboxylic acid dimethylamide;
8-(3,4-Dimethoxy-benzyloxy)-naphthalene-1-carboxylic acid dimethylamide;
8-(3,4,5-Trimethoxy-benzyloxy)-naphthalene-1-carboxylic acid dimethylamide;
8-(3,5-Dimethoxy-benzyloxy)-naphthalene-1-carboxylic acid dimethylamide;
8-(Biphenyl-4-ylmethoxy)-naphthalene-1-carboxylic acid dimethylamide;
8-(4-Benzyloxy-benzyloxy)-naphthalene-1-carboxylic acid dimethylamide;
8-(4-Styryl-benzyloxy)-naphthalene-1-carboxylic acid dimethylamide;
8-Hydroxy-naphthalene-1-carboxylic acid benzyl-phenethyl-amide;
8-(4-Benxyloxy-benzyloxy)-naphthalene-1-carboxylic acid benzyl-phenethyl-amide;
8-(4-Benxyloxy-benzyloxy)-naphthalene-1-carboxylic acid benzyl-ethyl-amide;
8-(4-Benxyloxy-benzyloxy)-naphthalene-1-carboxylic acid [1-(1H-indol-3-yl)-ethyl]-isoproyl-amide; and
8-(4-Benxyloxy-benzyloxy)-naphthalene-1-carboxylic acid [2-(2-methoxy-phenyl)-ethyl]-phenethyl-amide.
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Specification