Method of and system for measuring glucose concentration

• US 6,226,089 B1
• Filed: 07/26/1999
• Issued: 05/01/2001
• Est. Priority Date: 07/24/1998
• Status: Expired due to Fees

• Current Assignee: Fujifilm Corporation (Fujifilm Holdings Corporation)
• Original Assignee: Fuji Photo Film Co Limited (Fujifilm Holdings Corporation)
• Inventors: Hakamata, Kazuo
• Primary Examiner(s): Font, Frank G.
• Assistant Examiner(s): NATIVIDAD, PHILIP SANA
• Application Number:
  US09/359,642
• Time in Patent Office: 645 Days
• Field of Search: 356/432, 600/319
• US Class Current: 356/432
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: G01N 21/41 Refractivity; Phase-affecting properties, e.g. optical path length G01N21/21 takes precedence
• CPC Class Codes: G01N 21/49 within a body or fluid

Abstract

The intensities of backscattering light generated by predetermined interfaces of an eyeball when a laser beam emitted from a semiconductor laser is projected onto the eyeball in a predetermined position are detected. The absorbance or refractive index of the aqueous humor in the anterior chamber of the eyeball is determined on the basis of the intensities of the backscattering light, and the glucose concentration in the aqueous humor is determined on the basis of the absorbance or refractive index of the aqueous humor in the anterior chamber thus determined. An extinction filter is disposed on the optical path of the laser beam between the semiconductor laser and the eyeball so that the intensity of the laser beam entering the eyeball is reduced not higher than a predetermined value of MPE.

Claims

1. A method of measuring a glucose concentration in aqueous humor in an anterior chamber of an eyeball, comprising the steps of:

(a) projecting a semiconductor laser beam onto the eyeball which is placed at a predetermined position;

(b) detecting intensities of backscattered light generated by predetermined interfaces of the eyeball;

(c) measuring absorbance or refractive indexes of the aqueous humor in the anterior chamber of the eyeball based on the intensities of the backscattered light, wherein a single wavelength of the laser beam provides sufficient information for determining the intensity of the backscattered light which is reflected from the predetermined interfaces of the eyeball;

(d) determining the glucose concentration in the aqueous humor based on the absorbance or refractive indexes of the aqueous humor in the anterior chamber of the eyeball thus determined; and

(e) controlling an intensity of the laser beam by disposing an extinction filter on an optical path of the laser beam between said semiconductor laser and the eyeball so that the intensity of the laser beam entering the eyeball is reduced not higher than a predetermined value of maximum permissible exposure.

2. The method as defined in claim 1, wherein the semiconductor laser emits a laser beam in a visible region or a near-infrared region at an intensity of several mW and the extinction filter is an ND filter whose optical density is in the range of 3 to 4 inclusive.

9. The method of measuring the glucose concentration in aqueous humor in the anterior chamber of the eyeball according to claim 1, wherein the step of detecting intensities of backscattered light is performed by measuring the intensities of a beat signal which beats at a frequency difference between the backscattered light and a reference light beam.

10. The method of measuring the glucose concentration in aqueous humor in the anterior chamber of the eyeball according to claim 1, wherein the wavelength of the semiconductor laser beam is modified so that the absorption properties of the aqueous humor are temperature independent.

11. The method of measuring the glucose concentration in aqueous humor in the anterior chamber of the eyeball according to claim 1, wherein correction coefficients are employed to correct the refractive indexes due to temperature variations in the eyeball.

3. A method of measuring a glucose concentration in aqueous humor in an anterior chamber of an eyeball, comprising the steps of:

(a) projecting a semiconductor laser beam onto the eyeball which is placed in a predetermined position;

(b) detecting a state of elliptical polarization of backscattered light generated by a predetermined interface of the eyeball;

(c) measuring a refractive index of the aqueous humor in the anterior chamber of the eyeball based on the state of elliptical polarization of the backscattered light, wherein a single wavelength of the laser beam provides sufficient information for determining the elliptical polarization of the backscattered light which is reflected from the predetermined interfaces of the eyeball;

(d) determining the glucose concentration in the aqueous humor based on the refractive index of the aqueous humor in the anterior chamber thus determined; and

(e) controlling an intensity of the laser beam by disposing an extinction filter on an optical path of the laser beam between the semiconductor laser and the eyeball so that the intensity of the laser beam entering the eyeball is reduced not higher than a predetermined value of maximum permissible exposure.

4. The method as defined in claim 3, wherein the semiconductor laser emits a laser beam in a visible region the extinction filter is an ND filter whose optical density is in the range of 3 to 4 inclusive.

12. The method of measuring the glucose concentration in aqueous humor in the anterior chamber of the eyeball according to claim 3, wherein the step of detecting intensities of backscattered light is performed by measuring the intensities of a beat signal which beats at a frequency difference between the backscattered light and a reference light beam.

13. The method of measuring the glucose concentration in aqueous humor in the anterior chamber of the eyeball according to claim 3, wherein the wavelength of the semiconductor laser beam is varied so that the absorption properties of the aqueous humor are temperature independent.

14. The method of measuring the glucose concentration in aqueous humor in the anterior chamber of the eyeball according to claim 3, wherein correction coefficients are employed to correct the refractive indexes due to temperature variations in the eyeball.

5. A glucose concentration measuring system, comprising:

a semiconductor laser which projects a laser beam onto an eyeball placed at a predetermined position;

a detector which detects intensities of backscattered light generated by predetermined interfaces of the eyeball, wherein absorbance or refractive indexes of aqueous humor in an anterior chamber of the eyeball is measured based on the intensities of the backscattered light, wherein a single wavelength of the laser beam provides sufficient information for determining the intensities of the backscattered light which are reflected from the predetermined interfaces of the eyeball, and wherein the glucose concentration in the aqueous humor is determined based on the absorbance or refractive indexes of the aqueous humor in the anterior chamber thus determined; and

an extinction filter disposed on an optical path of the laser beam between the semiconductor laser and the eyeball so that an intensity of the laser beam entering the eyeball is reduced not higher than a predetermined value of maximum permissible exposure.

6. The glucose concentration measuring system as defined in claim 5 wherein the semiconductor laser emits a laser beam in a visible region or a near-infrared region at an intensity of several mW and the extinction filter is an ND filter whose optical density is in the range of 3 to 4 inclusive.

15. The glucose concentration measuring system according to claim 5, wherein a photodetector detects the intensities of backscattered light.

7. A glucose concentration measuring system comprising:

a semiconductor laser which projects a laser beam onto an eyeball placed at a predetermined position;

a detector which detects a state of elliptical polarization of backscattered light generated by predetermined interfaces of an eyeball, wherein a refractive index of aqueous humor in an anterior chamber of the eyeball is determined based on the state of elliptical polarization of the backscattered light, wherein a single wavelength of the laser beam provides sufficient information for determining the elliptical polarization of the backscattered light which is reflected from the predetermined interfaces of the eyeball, and wherein the glucose concentration in the aqueous humor is determined based on the refractive index of the aqueous humor in the anterior chamber thus determined; and

an extinction filter disposed on an optical path of the laser beam between the semiconductor laser and the eyeball so that an intensity of the laser beam entering the eyeball is reduced not higher than a predetermined value of maximum permissible exposure.

8. The glucose concentration measuring system as defined in claim 7 wherein the semiconductor laser emits a laser beam in a visible region or a near-infrared region at an intensity of several mW and the extinction filter is an ND filter whose optical density is in the range of 3 to 4 inclusive.

16. The glucose concentration measuring system according to claim 7, wherein a photodetector detects the intensities of backscattered light.