Apparatus and method for non-invasively measuring cardiac output

• US 6,227,196 B1
• Filed: 03/02/1999
• Issued: 05/08/2001
• Est. Priority Date: 12/19/1996
• Status: Expired due to Term

• Current Assignee: RIC INVESTMENTS LLC (Koninklijke Philips N.V.)
• Original Assignee: NTC Technology, Inc. (Dixtal Medical, Inc.)
• Inventors: Orr, Joseph A., Jaffe, Michael B., Westenskow, Dwayne, Kofoed, Scott A.
• Primary Examiner(s): O'Connor, Cary
• Assistant Examiner(s): CARTER, RYAN CHRISTOPHER
• Application Number:
  US09/262,510
• Time in Patent Office: 798 Days
• Field of Search: 128/200.26, 128/200.24, 600/529, 600/532, 600/538, 600/540, 600/481, 600/483, 600/500
• US Class Current: 128/200.26
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/0836 Measuring rate of CO2 production
• CPC Class Codes: A61M 16/0045 Means for re-breathing exhaled gases, e.g. for hyperventilation treatment
• CPC Class Codes: A61M 16/0833 T- or Y-type connectors, e.g. Y-piece
• CPC Class Codes: A61M 2016/0036 in the breathing tube and used in both inspiratory and expiratory phase
• CPC Class Codes: A61M 2230/432 partial CO2 pressure (P-CO2)
• CPC Class Codes: G01N 33/004 CO or CO2
• CPC Class Codes: Y02A 50/20 Air quality improvement or preservation, e.g. vehicle emission control or emission reduction by using catalytic converters

Abstract

Apparatus and methods for non-invasively determining the cardiac output or pulmonary capillary blood flow of a patient using partial re-breathing techniques. The apparatus includes a substantially instantaneously adjustable deadspace volume for accommodating differences in sizes or breathing capacities of various patients. The apparatus may be constructed of inexpensive elements, including one or more two-way valves, which render the apparatus very simple to use and inexpensive so that the unit may be employed as a disposable product. The method of the invention includes estimating the cardiac output or pulmonary capillary blood flow of a patient based on partial pressure of alveolar CO₂ rather than on the partial pressure of end tidal CO₂, as previously practiced. A computer program for calculating the cardiac output or pulmonary capillary blood flow of a patient is also disclosed.

Claims

1. An apparatus for determining a cardiac output or a pulmonary capillary blood flow of a patient, comprising:

a conduit adapted for flow communication with a respiratory system of the patient;

a deadspace adjustable between more than two volumes and positionable in flow communication with said conduit to receive a volume of gas comprising carbon dioxide for subsequent breathing by the patient; and

at least one detection component in communication with said conduit and capable of detecting changes in respiration of the patient.

2. The apparatus of claim 1, wherein said deadspace is positioned to receive gas expired by the patient.

3. The apparatus of claim 1, further comprising a flow meter in communication with said conduit.

4. The apparatus of claim 1, further comprising a carbon dioxide sensor in communication with said conduit.

5. The apparatus of claim 1, further comprising a valve substantially disposable across a flow path of said deadspace.

6. The apparatus of claim 5, wherein said valve comprises a two-way valve or a three-way valve.

7. The apparatus of claim 5, wherein said valve is positionable to restrict flow into or through said deadspace.

8. The apparatus of claim 5, wherein said valve is positionable to permit flow into or through said deadspace.

9. The apparatus of claim 1, wherein said deadspace includes an evacuation element.

10. The apparatus of claim 9, wherein said evacuation element comprises a valve.

11. The apparatus of claim 10, wherein said evacuation element comprises an evacuation line in flow communication with said valve.

12. The apparatus of claim 10, wherein said evacuation element further comprises a receptacle in flow communication with said valve.

13. The apparatus of claim 9, wherein said evacuation element is configured to release gas from said deadspace to effectively reduce the volume of said deadspace.

14. The apparatus of claim 9, wherein said evacuation element is configured to facilitate introduction of gas into said deadspace to effectively increase the volume of said deadspace.

15. The apparatus of claim 1, further comprising a ventilation source in flow communication with said conduit.

16. The apparatus of claim 1, wherein said deadspace comprises a tracheal gas insufflation device.

17. The apparatus of claim 1, further comprising an inspiratory course in flow communication with said conduit and an expiratory course in flow communication with said conduit.

18. The apparatus of claim 17, wherein said deadspace at least partially comprises said inspiratory course.

19. The apparatus of claim 17, wherein said deadspace at least partially comprises said expiratory course.

20. The apparatus of claim 17, further comprising a plurality of shunt lines extending between said expiratory course and said inspiratory course, at least one of said plurality of shunt lines including a valve disposable substantially across a flow path thereof.

21. The apparatus of claim 17, wherein said expiratory course includes a section of expandable volume.

22. The apparatus of claim 17, wherein said inspiratory course includes a section of expandable volume.

23. The apparatus of claim 17, further comprising a Y-piece adjoining said inspiratory course and said expiratory course to said conduit.

24. The apparatus of claim 17, wherein said deadspace includes at least one shunt line extending between said expiratory course and said inspiratory course.

25. The apparatus of claim 24, wherein said at least one shunt line comprises a section of expandable volume.

26. The apparatus of claim 1, wherein said deadspace comprises an air passage positionable in flow communication with said conduit.

27. The apparatus of claim 26, wherein said air passage includes two ends, each of said two ends in flow communication with said conduit.

28. The apparatus of claim 27, further comprising a flow restrictor in said conduit between said two ends.

29. The apparatus of claim 26, further comprising a valve disposable substantially across a flow path of said air passage.

30. The apparatus of claim 29, wherein said valve comprises a two-way valve or a three-way valve.

31. The apparatus of claim 26, wherein a volume of said air passage is adjustable.

32. An apparatus for determining a cardiac output or a pulmonary capillary blood flow of a patient, comprising a conduit configured to communicate with a respiratory system of the patient and including an evacuation element comprising a valve for selectively releasing a volume of gas exhaled by the patient from said conduit or for facilitating introduction of gas into a deadspace including at least a portion of the conduit.

33. The apparatus of claim 32, wherein said evacuation element comprises an evacuation line.

34. The apparatus of claim 32, wherein said evacuation element comprises a receptacle.

35. The apparatus of claim 32, further comprising a ventilation source in communication with said conduit.

36. The apparatus of claim 32, wherein said conduit comprises an airway conduit, an expiratory course in communication with said airway conduit, and an inspiratory course in communication with said airway conduit.

37. An apparatus for determining a cardiac output or a pulmonary capillary blood flow of a patient, comprising a conduit configured to communicate with [an airway] a respiratory system of the patient, a gas source in communication with said conduit, and a gas insufflation component in communication with said airway.

38. An apparatus of claim 37, further comprising an inspiratory course and an expiratory course in communication with said conduit and with said gas source.

39. The apparatus of claim 37, wherein said gas insufflation component is selectively modifiable so as to alter an effective deadspace comprising at least said airway.

40. A method of determining a cardiac output or a pulmonary capillary blood flow of a patient, comprising:

measuring gas flow and carbon dioxide partial pressure during substantially normal respiration or ventilation of the patient;

calculating a carbon dioxide elimination and an end-tidal partial pressure of carbon dioxide from said gas flow and said carbon dioxide partial pressure;

measuring gas flow and carbon dioxide partial pressure during re-breathing to determine an end-tidal pressure change in said end-tidal partial pressure of carbon dioxide and a volume change in said carbon dioxide elimination;

estimating an anatomic deadspace partial pressure of carbon dioxide in an anatomic deadspace of the patient and a parallel deadspace partial pressure of carbon dioxide in a parallel deadspace of the patient;

selecting a functional residual capacity value;

correcting said carbon dioxide elimination based at least in part on said functional residual capacity value and on said end-tidal pressure change;

determining an alveolar partial pressure of carbon dioxide based at least in part on said end-tidal partial pressure of carbon dioxide and said parallel deadspace partial pressure of carbon dioxide;

determining an alveolar pressure change in said alveolar partial pressure of carbon dioxide effected by said re-breathing; and

determining the cardiac output or the pulmonary capillary blood flow from said volume change and said alveolar pressure change.

41. The method of claim 40, further comprising determining a baseline alveolar partial pressure of carbon dioxide.

42. The method of claim 41, wherein said determining said baseline alveolar partial pressure of carbon dioxide comprises determining said baseline alveolar partial pressure of carbon dioxide during said substantially normal respiration or ventilation.

43. The method of claim 41, further comprising comparing said baseline alveolar partial pressure of carbon dioxide and said alveolar pressure change.

44. The method of claim 43, further comprising adjusting an effective volume of re-breathed gas if said alveolar pressure change exceeds a first threshold or is below a second threshold.

45. The method of claim 44, wherein said adjusting comprises changing a volume of re-breathed gas.

46. The method of claim 44, wherein said adjusting comprises changing a carbon dioxide fraction of re-breathed gas.

47. The method of claim 40, further comprising determining a baseline carbon dioxide elimination.

48. The method of claim 47, wherein said determining said baseline carbon dioxide elimination comprises determining said baseline carbon dioxide elimination during said substantially normal respiration or ventilation.

49. The method of claim 47, further comprising comparing said baseline carbon dioxide elimination and said volume change.

50. The method of claim 49, further comprising adjusting an effective volume of re-breathed gas if said volume change exceeds a first threshold or is below a second threshold.

51. The method of claim 50, wherein said adjusting comprises changing a volume of re-breathed gas.

52. The method of claim 50, wherein said adjusting comprises changing a carbon dioxide fraction of re-breathed gas.

53. The method of claim 40, wherein said determining said alveolar partial pressure of carbon dioxide includes estimating a perfusion ratio.

54. The method of claim 53, wherein said estimating said perfusion ratio comprises employing the following equation:

55. The method of claim 54, further comprising measuring said arterial partial pressure of carbon dioxide.

56. The method of claim 55, wherein said measuring said arterial partial pressure of carbon dioxide comprises directly measuring said arterial partial pressure of carbon dioxide.