System and method for controlling tissue ablation

• US 6,228,076 B1
• Filed: 01/09/1999
• Issued: 05/08/2001
• Est. Priority Date: 01/09/1999
• Status: Expired due to Term

• Current Assignee: Spectranetics Corporation (Koninklijke Philips N.V.)
• Original Assignee: IntraLuminal Therapeutics, Inc. (DSM-Firmenich AG)
• Inventors: Winston, Thomas R., Neet, John M.
• Primary Examiner(s): Cohen, Lee
• Assistant Examiner(s): FARAH, AHMED M
• Application Number:
  US09/228,030
• Time in Patent Office: 850 Days
• Field of Search: 606/2, 606/10-12, 606/15-17, 356/345, 356/318, 356/346, 600/439, 128/664, 128/660.03, 128/303.1, 128/898, 250/458.1
• US Class Current: 606/11
• CPC Class Codes: A61B 17/00 Surgical instruments, devices or methods, e.g. tourniquets A61B18/00 takes precedence; contraceptive devices, pessaries, or applicators therefor A61F6/00; eye surgery A61F9/007; ear surgery A61F11/00
• CPC Class Codes: A61B 18/00 Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body eye surgery A61F9/007; ear surgery A61F11/00
• CPC Class Codes: A61B 18/1206 Generators therefor
• CPC Class Codes: A61B 2017/00061 spectrum

Abstract

A control system and method for controlling tissue ablation uses optical time domain reflectometry data to differentiate abnormal tissue from normal tissue, and to control ablation of abnormal tissue by controlling a tissue ablative apparatus. Using data provided by an interferometric apparatus, the control system provides control signals to the tissue ablative apparatus, controlling activation of the tissue ablation apparatus so that normal tissue is left untreated while abnormal tissue is ablated.

Claims

1. A method for controlling tissue ablation using a tissue ablation system, the tissue ablation system including a control system coupled to tissue ablative apparatus and to interferometric apparatus, the control system configured to use interferomtric data from the interferomtric apparatus to detect interfaces between normal and abnormal tissue, said method comprising the steps of:

generating interferometric data from a tissue with the interferometeric apparatus;

providing the interferometric data to the control system to detect whether an interface between an abnormal tissue and a normal tissue is present; and

if an interface is present, generating control signals with the control system to alter the operation of the tissue ablative apparatus.

2. A method in accordance with claim 1 wherein detecting whether an interface between an abnormal tissue and a normal tissue is present comprises the step of detecting whether abnormal tissue is present.

3. A method in accordance with claim 2 wherein altering the operation of the tissue ablative apparatus comprises the step of enabling the tissue ablative apparatus so that the abnormal tissue is ablated.

4. A method in accordance with claim 3 wherein detecting whether an interface between an abnormal tissue and a normal tissue is present further comprises the step of advancing the tissue ablative apparatus into an area having abnormal tissue until normal tissue is detected.

5. A method in accordance with claim 4 wherein altering the operation of the tissue ablative apparatus further comprises the step of, if normal tissue is detected, then disenabling the tissue ablative apparatus.

6. A method in accordance with claim 1 wherein detecting whether an interface between an abnormal tissue and a normal tissue is present comprises the step of detecting whether normal tissue is present.

7. A method in accordance with claim 6 wherein detecting whether an interface between an abnormal tissue and a normal tissue is present further comprises the step of, if normal tissue is present, altering the position of the tissue ablative apparatus until abnormal tissue is detected.

8. A method in accordance with claim 7 wherein the tissue ablative apparatus includes a stepping motor, and wherein altering the position of the tissue ablative apparatus comprises the step of altering control signals supplied to the stepping motor.

9. A method in accordance with claim 7 wherein altering the operation of the tissue ablative apparatus comprises the steps of:

if abnormal tissue is detected, then advancing the tissue ablative apparatus into the abnormal tissue; and

enabling the tissue ablative apparatus.

10. A method in accordance with claim 1 wherein the control system is coupled to an interferometric apparatus, and wherein detecting whether an interface is present comprises the steps of:

generating interference data; and

using the interference data to identify the interface between an abnormal tissue and a normal tissue.

11. A method in accordance with claim 10 wherein the interferometric apparatus includes a sampling optical fiber having a distal sampling end, and wherein detecting whether an interface between normal tissue and abnormal tissue is present comprises the steps of:

generating a function from the interference data for reflected light intensity versus distance from the sampling end of the sampling optical fiber; and

examining the rate of decay of the function.

12. A method in accordance with claim 11 wherein examining the rate of decay of the function comprises the step of identifying actual inflection points of the function.

13. A method in accordance with claim 10 further comprising the step of using the interference data to generate a psuedoimage of a tissue.

14. A method in accordance with claim 1 wherein the control system is coupled to a spectroscopic apparatus, and wherein detecting whether an interface is present comprises the steps of:

generating spectroscopic data; and

using the spectroscopic data to identify an interface between abnormal tissue and normal tissue.

15. A method in accordance with claim 1 wherein the tissue ablative apparatus includes a tissue ablative element coupled to an energy source, the energy source coupled to the control system, and wherein altering the operation of the tissue ablative apparatus comprises the step of altering control signals supplied to the energy source.

16. A control system for controlling tissue ablative apparatus, said control system comprising:

a microprocessor and an energy controller, said control system configured for coupling to the tissue ablative apparatus and to interferometric apparatus, said control system configured to use interferometric data from the interferometric apparatus to detect whether an interface between an abnormal tissue and a normal tissue is present and if an interface is present, to generate control signals to the energy controller to alter the operation of the tissue ablative apparatus.

17. A system in accordance with claim 16 wherein the interferometric apparatus includes a sampling optical fiber having a distal sampling end, and wherein to detect whether an interface between normal tissue and abnormal tissue is present, said system is configured to:

generate a function for reflected light intensity against distance from the sampling end of the sampling optical fiber utilizing the interference data; and

determine a rate of decay of the function.

18. A system in accordance with claim 17 wherein to determine the rate of decay of the function, said system is configured to identify actual inflection points of the function.

19. A system in accordance with claim 16 further configured to generate a psuedoimage of a tissue utilizing the interference data.

20. A system in accordance with claim 16 wherein a spectroscopic apparatus configured to generate spectroscopic data is coupled to said control system, and wherein to detect whether an interface is present, said system is configured to:

identify an interface between abnormal tissue and normal tissue using the spectroscopic data.

21. A system in accordance with claim 20 wherein the spectroscopic apparatus comprises Raman spectroscopic apparatus.

22. A system in accordance with claim 20 wherein the spectroscopic apparatus comprises Rayleigh spectroscopic apparatus.

23. A system in accordance with claim 16 wherein to alter the operation of the tissue ablative apparatus, said system is configured to enable the tissue ablative apparatus to ablate the abnormal tissue, if an interface between normal and abnormal tissue is detected.

24. A system in accordance with claim 16 wherein to alter the operation of the tissue ablative apparatus, said system is configured to disenable the tissue ablative apparatus so that the normal tissue is unharmed, if an interface between abnormal and normal tissue is detected.

25. A system in accordance with claim 16 wherein the tissue ablative apparatus includes a tissue ablative element coupled to an energy source, the energy source coupled to said control system, and wherein to alter the operation of the tissue ablative apparatus, said system is configured to alter control signals supplied to the energy source.

26. A system in accordance with claim 16 wherein the tissue ablative apparatus includes a stepping motor, and wherein to alter the operation of the tissue ablative apparatus, said system configured to alter control signals supplied to the stepping motor.

27. A tissue ablation system for ablating tissue, said system comprising:

tissue ablative apparatus comprising a tissue ablative element and an ablation energy source;

interferometric apparatus comprising a low coherent light source, for providing interference data; and

a control system coupled to said interferometric apparatus, said control system comprising a microprocessor and an energy controller coupled to said ablation energy source for altering an energy signal supplied to said tissue ablative apparatus, said control system configured to use the interference data to detect whether an interface between normal tissue and abnormal tissue is present and if the interface is present, alter the energy signal supplied to the tissue ablative apparatus.

28. A system in accordance with claim 27 wherein said tissue ablative element comprises a laser catheter.

29. A system in accordance with claim 27 wherein said tissue ablative element comprises a radio frequency device.

30. A system in accordance with claim 27 wherein said tissue ablative element comprises a mechanical atherectomy device.

31. A system in accordance with claim 27 wherein said tissue ablative element comprises an ultrasound device.

32. A system in accordance with claim 27 wherein said tissue ablative element comprises a microwave device.

33. A system in accordance with claim 27 further comprising an output display device coupled to said microprocessor.

34. A system in accordance with claim 33 wherein said output display device comprises a computer monitor.