Water resistant film-forming antimicrobial skin-preparation
First Claim
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1. An aqueous solution for use as a water resistant film-forming antimicrobial skin-preparation, the aqueous solution comprising:
- a polyvinyl lactam;
a broad spectrum antimicrobial agent chemically complexed with the polyvinyl lactam;
a water-resistant polymer system wherein the water-resistant polymer system includes octylacrylamide;
a pH sensitive polymer wherein the pH sensitive polymer includes an aqueous methacrylic polymer;
a neutralizer; and
an alcohol.
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Abstract
A water-resistant, film-forming topical antimicrobial composition, removable by high pH solution, made in accordance with the principles of the present invention includes a polyvinyl lactam, a broad spectrum antimicrobial agent, a copolymer of polyacrylate/polyoctylacrylamide, a pH sensitive acrylic polymer, and an alcohol. Preferably, the polyvinyl lactam is polyvinyl pyrrolidone. The preferred broad spectrum antimicrobial agent is iodine which is preferably complexed to the polyvinyl pyrrolidone. A process for making the film-forming topical antimicrobial composition is also provided.
115 Citations
143 Claims
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1. An aqueous solution for use as a water resistant film-forming antimicrobial skin-preparation, the aqueous solution comprising:
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a polyvinyl lactam;
a broad spectrum antimicrobial agent chemically complexed with the polyvinyl lactam;
a water-resistant polymer system wherein the water-resistant polymer system includes octylacrylamide;
a pH sensitive polymer wherein the pH sensitive polymer includes an aqueous methacrylic polymer;
a neutralizer; and
an alcohol. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
further wherein n1 is selected from the integers 2 through 6000 and wherein R is selected from the group consisting of unbranched alkyl, branched alkyl, unbranched alcohol, branched alcohol, ester, ether, aryl groups, and combinations thereof.
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11. The composition of claim 10 further wherein the non-aryl R substituents are selected from the group consisting of C1 through C6 moieties, and combinations thereof.
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12. The composition of claim 11 wherein the non-aryl substituents are selected from the group consisting of C1 through C4 moieties, and combinations thereof.
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13. The composition of claim 6 wherein the polyacrylate comprises:
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further wherein n2 is from 2 through 6000 and wherein M is selected from the group consisting of Group I of the Periodic Table, and combinations thereof.
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14. The composition of claim 13 further wherein M is selected from the group consisting of sodium, potassium, and combinations thereof.
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15. The composition of claim 1 further comprising a polyvinyl alcohol.
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16. The composition of claim 15 wherein the polyvinyl alcohol comprises:
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further wherein n4 is selected from the integers 2 through 3400.
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17. The composition of claim 15 wherein the weight average of the molecular weight of polyvinyl alcohol is between 50,000 to 150,000.
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18. The composition of claim 1 further comprising a polyvinyl acetate.
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19. The composition of claim 18 wherein the polyvinyl acetate comprises:
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further wherein n3 is selected from the integers 2 through 2100.
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20. The composition of claim 18 wherein the polyvinyl acetate has a weight average molecular weight of from about 130,000 to about 180,000.
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21. The composition of claim 1 further comprising a polyvinyl alcohol and a polyvinyl acetate.
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22. The composition of claim 1 wherein the pH sensitive polymer is present in an amount of from about 0.1% w/v to about 10% w/v.
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23. The composition of claim 22 wherein the pH sensitive polymer is present in an amount of from about 0.2% w/v to about 1% w/v.
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24. The composition of claim 1 wherein the pH sensitive polymer is a copolymer of poly(methacrylic acid, methylmethacrylate).
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25. The composition of claim 15 wherein the polyvinyl alcohol is present in an amount from about 0.1% w/v to about 10% w/v.
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26. The composition of claim 25 wherein the polyvinyl alcohol is present in an amount from about 0.5% w/v to about 5% w/v.
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27. The composition of claim 18 wherein the polyvinyl acetate is present in an amount from about 0.1% w/v to about 10% w/v.
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28. The composition of claim 27 wherein the polyvinyl acetate is present in an amount from about 0.5% w/v to about 5% w/v.
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29. The composition of claim 21 wherein the combination of the polyvinyl alcohol and polyvinyl acetate is present in an amount from about 0.1% w/v to about 10% w/v.
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30. The composition of claim 29 wherein the combination of the polyvinyl alcohol and the polyvinyl acetate is present in an amount from about 0.5% w/v to about 5% w/v.
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31. The composition of claim 1 wherein the water resistant polymer system is a neutralized carboxylated acrylic copolymer containing acrylates and octylacrylamide.
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32. The composition of claim 1 wherein the water resistant polymer system is a carboxylated acrylic copolvmer of acrylates and octylacrylamide.
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33. The composition of claim 1 wherein the neutralizer is selected from the group consisting of triethanolamine, 2-amino-2-methyl-1-propanol, ammonium hydroxide, potassium hydroxide, and combinations thereof.
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34. An aqueous solution for use as a water resistant film-forming antimicrobial skin-preparation, the aqueous solution comprising:
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PVP-I;
a water-resistant polymer system wherein the water-resistant polymer system includes octylacrylamide;
a pH sensitive polymer wherein the pH sensitive polymer includes an aqueous methacrylic polymer;
a neutralizer, and an alcohol. - View Dependent Claims (35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63)
further wherein n1 is selected from the integers 2 through 6000 and wherein R is selected from the group consisting of unbranched alkyl, branched alkyl, unbranched alcohol, branched alcohol, ester, ether, aryl groups, and combinations thereof.
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42. The composition of claim 41 further wherein the non-aryl R substituents are selected from the group consisting of C1 through C6 moieties, and combinations thereof.
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43. The composition of claim 42 wherein the non-aryl substituents are selected from the group consisting of C1 through C4 moieties, and combinations thereof.
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44. The composition of claim 37 wherein the polyacrylate further comprises:
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wherein n2 is from 2 through 6000 and wherein M is selected from the group consisting of Group I of the Periodic Table, and combinations thereof.
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45. The composition of claim 44 wherein M is selected from the group consisting of sodium, potassium, and combinations thereof.
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46. The composition of claim 34 further comprising a polyvinyl alcohol.
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47. The composition of claim 46 wherein the polyvinyl alcohol further comprises:
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wherein n4 is selected from the integers 2 through 3400.
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48. The composition of claim 46 wherein the weight average of the molecular weight of polyvinyl alcohol is between 50,000 to 150,000.
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49. The composition of claim 34 further comprising a polyvinyl acetate.
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50. The composition of claim 49 wherein the polyvinyl acetate further comprises:
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wherein n3 is selected from the integers 2 through 2100.
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51. The composition of claim 49 wherein the polyvinyl acetate has a weight average molecular weight of from about 130,000 to about 180,000.
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52. The composition of claim 34 further comprising a polyvinyl alcohol and a polyvinyl acetate.
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53. The composition of claim 34 wherein the pH sensitive polymer is present in an amount of from about 0.1% w/v to about 10% w/v.
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54. The composition of claim 53 wherein the pH sensitive polymer is present in an amount of from about 0.2% w/v to about 1% w/v.
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55. The composition of claim 34 wherein the pH sensitive polymer is a copolymer of poly(methacrylic acid, methylmethacrylate).
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56. The composition of claim 46 wherein the polyvinyl alcohol is present in an amount from about 0.1% w/v to about 10% w/v.
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57. The composition of claim 56 wherein the polyvinyl alcohol is present in an amount from about 0.5% w/v to about 5% w/v.
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58. The composition of claim 49 wherein the polyvinyl acetate is present in an amount from about 0.1% w/v to about 10% w/v.
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59. The composition of claim 58 wherein the polyvinyl acetate is present in an amount from about 0.5% w/v to about 5% w/v.
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60. The composition of claim 52 wherein the combination of the polyvinyl alcohol and polyvinyl acetate is present in an amount from about 0.1% w/v to about 10% w/v.
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61. The composition of claim 60 wherein the combination of the polyvinyl alcohol and the polyvinyl acetate is present in an amount from about 0.5% w/v to about 5% w/v.
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62. The composition of claim 34 wherein the water resistant polymer system is a neutralized carboxylated acrylic copolymer of acrylates and octylacrylamide.
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63. The composition of claim 34 wherein the water resistant polymer system is a carboxylated acrylic copolymer of acrylates and octylacrylamide.
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64. A method for producing a film-forming topical antimicrobial composition, the method comprising the steps of:
- mixing together a polyvinyl lactam, a broad spectrum antimicrobial agent, an octylacrylamide, a polyacrylate, an aqueous methacrylic polymer, and an alcohol.
- View Dependent Claims (65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81)
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82. An aqueous solution for use as a water resistant film-forming antimicrobial skin-preparation, the aqueous solution comprising:
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a polyvinyl lactam;
a broad spectrum antimicrobial agent chemically complexed with the polyvinyl lactam;
a water-resistant polymer system wherein the water-resistant polymer system includes octylacrylamide;
a pH sensitive polymer wherein the pH sensitive polymer includes an aqueous methacrylic polymer; and
an alcohol. - View Dependent Claims (83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113)
wherein n1 is selected from the integers 2 through 6000 and wherein R is selected from the group consisting of unbranched alkyl, branched alkyl, unbranched alcohol, branched alcohol, ester, ether, aryl groups, and combinations thereof.
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92. The composition of claim 91 further wherein the non-aryl R substituents are selected from the group consisting of C1 through C6 moieties, and combinations thereof.
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93. The composition of claim 92 wherein the non-aryl substituents are selected from the group consisting of C1 through C4 moieties, and combinations thereof.
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94. The composition of claim 87 wherein the polyacrylate further comprises:
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wherein n2 is from 2 through 6000 and wherein M is selected from the group consisting of Group I of the Periodic Table, and combinations thereof.
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95. The composition of claim 94 further wherein M is selected from the group consisting of sodium, potassium, and combinations thereof.
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96. The composition of claim 82 further comprising a polyvinyl alcohol.
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97. The composition of claim 96 wherein the polyvinyl alcohol further comprises:
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wherein n4 is selected from the integers 2 through 3400.
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98. The composition of claim 96 wherein the weight average of the molecular weight of polyvinyl alcohol is between 50,000 to 150,000.
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99. The composition of claim 82 further comprising a polyvinyl acetate.
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100. The composition of claim 99 wherein the polyvinyl acetate further comprises:
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wherein n3 is selected from the integers 2 through 2100.
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101. The composition of claim 99 wherein the polyvinyl acetate has a weight average molecular weight of from about 130,000 to about 180,000.
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102. The composition of claim 82 further comprising a polyvinyl alcohol and a polyvinyl acetate.
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103. The composition of claim 82 wherein the pH sensitive polymer is present in an amount of from about 0.1% w/v to about 10% w/v.
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104. The composition of claim 103 wherein the pH sensitive polymer is present in an amount of from about 0.2% w/v to about 1% w/v.
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105. The composition of claim 82 wherein the pH sensitive polymer is a copolymer of poly(methacrylic acid, methylmethacrylate).
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106. The composition of claim 96 wherein the polyvinyl alcohol is present in an amount from about 0.1% w/v to about 10% w/v.
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107. The composition of claim 104 wherein the polyvinyl alcohol is present in an amount from about 0.5% w/v to about 5% w/v.
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108. The composition of claim 99 wherein the polyvinyl acetate is present in an amount from about 0.1% w/v to about 10% w/v.
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109. The composition of claim 108 wherein the polyvinyl acetate is present in an amount from about 0.5% w/v to about 5% w/v.
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110. The composition of claim 102 wherein the combination of the polyvinyl alcohol and polyvinyl acetate is present in an amount from about 0.1% w/v to about 10% w/v.
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111. The composition of claim 110 wherein the combination of the polyvinyl alcohol and the polyvinyl acetate is present in an amount from about 0.5% w/v to about 5% w/v.
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112. The composition of claim 82 wherein the water resistant polymer system is a neutralized carboxylated acrylic copolymer of acrylates and octylacrylamide.
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113. The composition of claim 82 wherein the water resistant polymer system is a carboxylated acrylic copolymer of acrylates and octylacrylamide.
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114. An aqueous solution for use as a water resistant film-forming antimicrobial skin-preparation, the aqueous solution comprising:
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PVP-I;
a water-resistant polymer system wherein the water-resistant polymer system includes octylacrylamide;
a sustained release polymer wherein the sustained release polymer includes copolymers of acrylic esters and methacrylic esters and the sustained release polymer further includes at least one quartemary ammonium group; and
an alcohol. - View Dependent Claims (115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143)
further wherein n1 is selected from the integers 2 through 6000 and wherein R is selected from the group consisting of unbranched alkyl, branched alkyl, unbranched alcohol, branched alcohol, ester, ether, aryl groups, and combinations thereof.
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122. The composition of claim 121 further wherein the non-aryl R substituents are selected from the group consisting of C1 through C6 moieties, and combinations thereof.
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123. The composition of claim 122 wherein the non-aryl substituents are selected from the group consisting of C1 through C4 moieties, and combinations thereof.
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124. The composition of claim 117 wherein the polyacrylate further comprises:
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wherein n2 is from 2 through 6000 and wherein M is selected from the group consisting of Group I of the Periodic Table, and combinations thereof.
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125. The composition of claim 124 wherein M is selected from the group consisting of sodium, potassium, and combinations thereof.
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126. The composition of claim 114 further comprising a polyvinyl alcohol.
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127. The composition of claim 126 wherein the polyvinyl alcohol further comprises:
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wherein n4 is selected from the integers 2 through 3400.
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128. The composition of claim 126 wherein the weight average of the molecular weight of polyvinyl alcohol is between 50,000 to 150,000.
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129. The composition of claim 114 further comprising a polyvinyl acetate.
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130. The composition of claim 129 wherein the polyvinyl acetate further comprises:
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wherein n3 is selected from the integers 2 through 2100.
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131. The composition of claim 129 wherein the polyvinyl acetate has a weight average molecular weight of from about 130,000 to about 180,000.
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132. The composition of claim 114 further comprising a polyvinyl alcohol and a polyvinyl acetate.
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133. The composition of claim 114 wherein the sustained release polymer is present in an amount of from about 0.1% w/v to about 10% w/v.
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134. The composition of claim 133 wherein the sustained release polymer is present in an amount of from about 0.2% w/v to about 1% w/v.
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135. The composition of claim 114 wherein the sustained release polymer is a copolymer of acrylic and methacrylic esters with a low content of quaternary ammonium groups.
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136. The composition of claim 126 wherein the polyvinyl alcohol is present in an amount from about 0.1% w/v to about 10% w/v.
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137. The composition of claim 136 wherein the polyvinyl alcohol is present in an amount from about 0.5% w/v to about 5% w/v.
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138. The composition of claim 129 wherein the polyvinyl acetate is present in an amount from about 0.1% w/v to about 10% w/v.
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139. The composition of claim 138 wherein the polyvinyl acetate is present in an amount from about 0.5% w/v to about 5% w/v.
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140. The composition of claim 132 wherein the combination of the polyvinyl alcohol and polyvinyl acetate is present in an amount from about 0.1% w/v to about 10% w/v.
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141. The composition of claim 140 wherein the combination of the polyvinyl alcohol and the polyvinyl acetate is present in an amount from about 0.5% w/v to about 5% w/v.
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142. The composition of claim 114 wherein the water resistant polymer system is a neutralized carboxylated acrylic copolymer of acrylates and octylacrylamide.
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143. The composition of claim 114 wherein the water resistant polymer system is a carboxylated acrylic copolymer of acrylates and octylacrylamide.
Specification