Therapeutic intraluminal stents
First Claim
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1. A method for making a stent to deliver nucleic acid to cells accessible from a wall of a body lumen comprising the steps of:
- providing a stent comprising a lumen-wall contacting surface, a lumen-exposed surface, and a first polymer composition comprising fibrin covering at least a portion of the lumen-wall contacting surface to form a polymer covered stent;
preparing virus capable of delivering nucleic acid to the walls of a body lumen; and
loading the virus on the first polymer composition.
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Abstract
This invention relates to an intraluminal stent having a lumen-wall contacting surface and a lumen-exposed surface wherein the stent comprises a first polymer composition comprising fibrin and wherein the stent is suitable to deliver virus to the wall of a lumen of the body. The invention also relates to methods for making the stent and to methods for delivering nucleic acid to cells accessible from a wall of a body lumen.
185 Citations
20 Claims
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1. A method for making a stent to deliver nucleic acid to cells accessible from a wall of a body lumen comprising the steps of:
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providing a stent comprising a lumen-wall contacting surface, a lumen-exposed surface, and a first polymer composition comprising fibrin covering at least a portion of the lumen-wall contacting surface to form a polymer covered stent;
preparing virus capable of delivering nucleic acid to the walls of a body lumen; and
loading the virus on the first polymer composition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A virus delivery composition comprising:
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a polymer composition comprising fibrin; and
virus capable of delivering nucleic acid to a cell.
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Specification