Method for enhancing outflow of aqueous humor in treatment of glaucoma
First Claim
1. A method for increasing aqueous humor outflow in the eye of a mammalian patient to reduce the intra-ocular pressure therein, said method comprising administering to said eye a composition comprising an effective amount of a compound that inhibits the Na+—
- K+—
2Cl−
co-transporter in the trabecular meshwork of the eye, or a pharmaceutically acceptable salt thereof.
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Abstract
Elevated intra-ocular pressure is reduced by administration directly to the eye of compounds that inhibit function of a Na+—K+—2Cl−2 cotransporter mechanism discovered in trabecular meshwork cells of mammalian eyes. These compounds are useful in treatment of diseases of the eye associated with elevated intra-ocular pressure, such as ocular hypertension and glaucoma. A screening method is provided to discover additional compounds with utility for lowering intra-ocular pressure by substantially inhibiting the Na+—K+—Cl−2 cotransporter mechanism in trabecular meshwork cells.
197 Citations
22 Claims
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1. A method for increasing aqueous humor outflow in the eye of a mammalian patient to reduce the intra-ocular pressure therein, said method comprising administering to said eye a composition comprising an effective amount of a compound that inhibits the Na+—
- K+—
2Cl−
co-transporter in the trabecular meshwork of the eye, or a pharmaceutically acceptable salt thereof. - View Dependent Claims (2, 3, 22)
- K+—
-
4. A method for increasing aqueous humor outflow in the eye of a mammalian patient to reduce the intra-ocular pressure therein, said method comprising administering to said eye a composition comprising an effective amount of a compound that inhibits the Na+—
- K+—
2Cl−
co-transporter in the trabecular meshwork of the eye, said compound selected from the group consisting of high ceiling diuretics. - View Dependent Claims (5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
- K+—
Specification