Apparatus for determining concentrations of light-absorbing materials in living tissue

• US 6,230,035 B1
• Filed: 07/19/1999
• Issued: 05/08/2001
• Est. Priority Date: 07/17/1998
• Status: Expired due to Fees

• Current Assignee: Nihon Kohden Corporation
• Original Assignee: Nihon Kohden Corporation
• Inventors: Xie, Chen-tai, Fuse, Masayoshi, Aoyagi, Takuo, Kanemoto, Michio
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US09/356,521
• Time in Patent Office: 659 Days
• Field of Search: 600/310, 600/322, 600/323, 600/336
• US Class Current: 600/336
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor

Abstract

Irradiating device 3 of a pulse oximeter includes a scattering plate 6. Scattering light is projected into a living tissue. The diameter of the incident area is sufficiently large compared with that of a light receiving area or vice versa. Therefore, tissue terms in a theoretical formula of Φ which represents a ratio of changes of optical densities of tissue measured with two wavelengths are not dependent on the wavelength. The digital processor 10 calculates an oxygen saturation by substituting Φ measured into simultaneous equations.

Claims

1. An apparatus for measuring a ratio of concentration of light absorbing materials in a living tissue, comprising:

irradiating means for irradiating a living tissue with scattered light of different wavelengths;

light receiving means for receiving either light transmitted through or light reflected from said living issue and for converting said light into corresponding electric signals; and

concentration-ratio processing means for calculating ratios of concentrations of light absorbing materials in accordance with said corresponding electric signals on the assumption that non-absorptive attenuation is equal independently of the wavelengths of light,

wherein said concentration-ratio processing means calculates changes of optical densities of the living tissue by use of pulsations of intensities of transmitted light, and calculates a ratio of concentrations of light absorbing materials by use of said calculated changes of the optical densities.

2. An apparatus as claimed in claim 1, wherein said irradiating means includes a scattering plate and light source for irradiating light to said living tissue through said scattering plate.

3. An apparatus for measuring a ratio of concentration of light absorbing materials in a living tissue, comprising:

irradiating means for irradiating a living tissue with scattered light of different wavelengths;

light receiving means for receiving either light transmitted through or light reflected from said living issue and for converting said light into corresponding electric signals; and

concentration-ratio processing means for calculating ratios of concentrations of light absorbing materials in accordance with said corresponding electric signals on the assumption that non-absorptive attenuation is equal independently of the wavelengths of light,

wherein said concentration-ratio processing means calculates a ratio of concentrations of light absorbing materials using a theoretical formula where values representing tissue exclusive of the blood at respective wavelengths are equal, and

wherein said concentration-ratio processing means calculates changes of optical densities of the living tissue by use of pulsations of intensities of transmitted light, and calculates a ratio of concentrations of light absorbing materials by use of said calculated changes of the optical densities.

4. An apparatus as claimed in claim 3, wherein said irradiating means includes a scattering plate and light source for irradiating light to said living tissue through said scattering plate.

5. An apparatus for measuring a ratio of concentration of light absorbing materials in a living tissue, comprising:

irradiating means for irradiating a living tissue with scattered light of different wavelengths;

light receiving means for receiving either light transmitted through or light reflected from said living issue and for converting said light into corresponding electric signals; and

concentration-ratio processing means for calculating ratios of concentrations of light absorbing materials in accordance with said corresponding electric signals on the assumption that non-absorptive attenuation is equal independently of the wavelengths of light,

wherein said concentration-ratio processing means includes;

optical density-change calculating means for calculating optical density changes Δ

A1 to Δ

A2, . . . Δ

An of n number of wavelengths from the pulsations of either light transmitted through or light reflected from said living tissue;

optical density change-ratio calculating means for calculating a ratio Φ

ij of two optical density changes (Δ

Ai, Δ

Aj), which are preselected from among the n number of optical density changes Δ

A1 to Δ

An calculated by said optical density-change calculating means;

processing means for calculating at least one of an arterial oxygen saturation and a ratio of concentrations of another in-blood light absorbing material by use of n−

1 number of Φ

ij obtained by said optical density change-ratio calculating means and an n−

1 number of simultaneous equations constructed such that values representing tissue exclusive of the blood at respective wavelengths are equal.

6. An apparatus for measuring a ratio of concentration of light absorbing materials in a living tissue, comprising:

irradiating means for irradiating a living tissue with scattered light of different wavelengths;

light receiving means for receiving either light transmitted through or light reflected from said living issue and for converting said light into corresponding electric signals; and

concentration-ratio processing means for calculating ratios of concentrations of light absorbing materials in accordance with said corresponding electric signals on the assumption that non-absorptive attenuation is equal independently of the wavelengths of light,

wherein said concentration-ratio processing means calculates a ratio of concentrations of light absorbing materials using a theoretical formula where values representing tissue exclusive of the blood at respective wavelengths are equal, and

wherein said concentration-ratio processing means includes;

optical density-change calculating means for calculating optical density changes Δ

A1 to Δ

A2, . . . Δ

An of n number of wavelengths from the pulsations of either light transmitted through or light reflected from said living tissue;

optical density change-ratio calculating means for calculating a ratio Φ

ij of two optical density changes (Δ

Ai, Δ

Aj), which are preselected from among the n number of optical density changes Δ

A1 to Δ

An calculated by said optical density change calculating means;

processing means for calculating at least one of an arterial oxygen saturation and a ratio of concentrations of another in-blood light absorbing material by use of n−

1 number of Φ

ij obtained by said optical density change-ratio calculating means and an n−

1 number of simultaneous equations constructed such that the values of tissue exclusive of the blood at respective wavelengths are equal.

7. An apparatus for measuring a ratio of concentration of light absorbing materials in a living tissue, comprising:

irradiating means for irradiating a living tissue with scattered light of different wavelengths;

light receiving means for receiving either light transmitted through or light reflected from said living issue and for converting said light into corresponding electric signals; and

concentration-ratio processing means for calculating ratios of concentrations of light absorbing materials in accordance with said corresponding electric signals on the assumption that non-absorptive attenuation is equal independently of the wavelengths of light,

wherein said concentration-ratio processing means calculates changes of optical densities of the living tissue by use of pulsations of intensities of transmitted light, and calculates a ratio of concentrations of light absorbing materials by use of said calculated changes of the optical densities, and

wherein said concentration-ratio processing means includes;

optical density-change calculating means for calculating optical density changes Δ

A1 to Δ

A2, . . . Δ

An of n number of wavelengths from the pulsations of either light transmitted through or light reflected from said living tissue;

optical density change-ratio calculating means for calculating a ratio Φ

ij of two density changes (Δ

Ai, Δ

Aj), which are preselected from among the n number of optical density changes Δ

A1 to Δ

An calculated by said optical density-change calculating means;

processing means for calculating at least one of an arterial oxygen saturation and a ratio of concentrations of another in-blood light absorbing material by use of n−

1 number of Φ

ij obtained by said optical density change-ratio calculating means and an n−

1 number of simultaneous equations constructed such that values representing tissue exclusive of the blood at respective wavelengths are equal.

8. An apparatus for measuring a ratio of concentration of light absorbing materials in a living tissue, comprising:

irradiating means for irradiating a living tissue with scattered light of different wavelengths;

light receiving means for receiving either light transmitted through or light reflected from said living issue and for converting said light into corresponding electric signals; and

concentration-ratio processing means for calculating ratios of concentrations of light absorbing materials in accordance with said corresponding electric signals on the assumption that non-absorptive attenuation is equal independently of the wavelengths of light,

wherein an area for receiving either light transmitted through said living tissue or light reflected from said living tissue is sufficiently larger or smaller than an irradiation area on said living tissue, and

wherein a ratio of said irradiating area on said living tissue to an effective area of said light receiving area on said living tissue is 1;

2 or more or 2 or more 0;

1.