Method for imaging an artery using a magnetic resonance contrast agent

• US 6,230,041 B1
• Filed: 07/29/1998
• Issued: 05/08/2001
• Est. Priority Date: 06/07/1993
• Status: Expired due to Term

• Current Assignee: Martin R. Prince
• Original Assignee: Martin R. Prince
• Inventors: Prince, Martin R.
• Primary Examiner(s): Casler, Brian L.
• Application Number:
  US09/124,262
• Time in Patent Office: 1,014 Days
• Field of Search: 600/420, 600/410, 600/419, 600/431, 324/307, 324/309, 424/9.36, 424/9.3
• US Class Current: 600/420
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/201 Assessing renal or kidney functions
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61B 5/7285 for synchronising or triggering a physiological measurement or image acquisition with a physiological event or waveform, e.g. an ECG signal A61B6/5205, A61B6/541, A61B8/5207, A61B8/543 take precedence
• CPC Class Codes: A61K 49/18 characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• CPC Class Codes: G01R 33/281 Means for the use of in vitro contrast agents G01R33/282 takes precedence; involving use of a contrast agent in MR imaging G01R33/5601; in vivo contrast agents A61K49/0002
• CPC Class Codes: G01R 33/5619 by temporal sharing of data, e.g. keyhole, block regional interpolation scheme for k-Space [BRISK]
• CPC Class Codes: G01R 33/563 of moving material, e.g. flow contrast angiography
• CPC Class Codes: G01R 33/56308 Characterization of motion or flow; Dynamic imaging

Abstract

The present invention is a technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides anatomic information, in the form of images, using a combination of a plurality of magnetic resonance angiography sequences, including a spin-echo and four contrast enhanced (e.g., gadolinium) magnetic resonance angiography sequences. The anatomic images may be used in, for example, pre-operative, operative and post-operative evaluation of aortic pathology, including aneurysms, atherosclerosis, and occlusive disease of branch vessels such as the renal arteries. The gadolinium-enhanced magnetic resonance angiography provides sufficient anatomic detail to detect aneurysms and all relevant major branch vessel abnormalities seen at angiography operation. This technique and apparatus allows for imaging the aorta at a fraction of the cost of conventional aortography and without the risks of arterial catheterization or iodinated contrast.

Claims

1. A method for imaging a portion of an artery of a patient using a magnetic resonance imaging system and an administered magnetic resonance contrast agent, the method comprising:

determining an arrival of the magnetic resonance contrast agent in a region of interest;

imaging at least a portion of the artery including collecting image data which is representative of a center of k-space after determining the arrival of the magnetic resonance contrast agent in the region of interest and while the concentration of the contrast agent in the portion of the artery is substantially greater than a concentration of the contrast agent in veins and background tissue adjacent to the portion of the artery.

2. The method of claim 1 wherein collecting image data which is representative of the center of k-space includes collecting the image data substantially at the beginning of an imaging sequence.

3. The method of claim 2 wherein the imaging sequence is a 3D imaging sequence.

4. The method of claim 1 further including monitoring the region of interest to determine an arrival of the contrast agent in the region of interest.

5. The method of claim 1 wherein collecting image data which is representative of a center of k-space includes collecting a portion of the image data while a concentration of the contrast agent in the portion of the artery is substantially a maximum.

6. The method of claim 1 further including administering the magnetic resonance contrast agent to the patient in a bolus type injection and wherein imaging at least a portion of the artery includes collecting image data of a 3D gradient echo pulse sequence and collecting image data which is representative of the center of k-space includes collecting the image data substantially at a beginning of the 3D imaging sequence.

7. The method of claim 1 wherein collecting image data includes collecting a substantial portion of the image data while the patient suspends respiration.

8. The method of claim 1 wherein collecting image data further includes using a TR which is less than about 25 milliseconds and a TE which is less than about 7 milliseconds.

9. The method of claim 1 wherein collecting image data further includes using a TR which is less than about 10 milliseconds, a TE which is less than about 7 milliseconds, and a flip angle which is between about 30°

and about 90°

.

10. The method of claim 1 further including:

collecting image data of a pre-contrast image data set including collecting image data before administering a substantial amount of the magnetic resonance contrast agent to the patient; and

constructing an image of the artery by subtracting the image data of the pre-contrast image data set from the image data acquired while the concentration of the contrast agent in the artery is substantially greater than a concentration of the contrast agent in veins and background tissue adjacent to the artery.

11. The method of claim 1 further including imaging at least one renal artery of the patient by collecting image data using a 3D gradient echo pulse sequence and coronally oriented image volume wherein the image volume includes at least a portion of the renal artery, the image data being collected while the concentration of the contrast agent in the renal artery is substantially greater than a concentration of the contrast agent in veins and background tissue adjacent to the renal artery.

12. The method of claim 1 further including imaging at least one renal artery of the patient by collecting image data which is representative of the center of k-space while the concentration of the contrast agent in the renal artery is substantially greater than a concentration of the contrast agent in veins and background tissue adjacent to the renal artery.

13. The method of claim 1 further including administering the magnetic resonance contrast agent to the patient by infusing the contrast agent to the patient at a rate which is greater than 0.0015 liters/kilogram-second² divided by the relaxivity of the contrast agent.

14. A method of imaging an artery of a patient using a magnetic resonance imaging system and an administered magnetic resonance contrast agent, the method comprising:

determining an arrival of the magnetic resonance contrast agent in a region of interest;

correlating collection of image data which is representative of the center of k-space with a concentration of the contrast in the artery which is substantially greater than a concentration of the contrast agent in veins and background tissue adjacent to the artery based on the arrival of the contrast agent in the region of interest.

15. The method of claim 14 wherein correlating collection of image data further includes collecting image data which is representative of the center of k-space while the concentration of the contrast in the artery is substantially greater than the concentration of the contrast agent in veins and background tissue adjacent to the artery.

16. The method of claim 15 wherein collecting image data which is representative of the center of k-space includes collecting the image data substantially at the beginning of an imaging sequence.

17. The method of claim 15 further including administering the magnetic resonance contrast agent to the patient in a bolus type injection and wherein collecting image data which is representative of the center of k-space includes collecting the image data substantially at a beginning of a 3D imaging sequence.

18. The method of claim 17 wherein collecting image data includes collecting a substantial portion of the image data while the patient suspends respiration.

19. The method of claim 15 wherein collecting image data further includes using a TR which is less than about 25 milliseconds and a TE which is less than about 7 milliseconds.

20. The method of claim 15 wherein collecting image data further includes using a TR which is less than about 10 milliseconds, a TE which is less than about 7 milliseconds, and a flip angle which is between about 30°

and about 90°

.

21. The method of claim 15 further including:

collecting image data of a pre-contrast image data set including collecting image data before administering a substantial amount of the magnetic resonance contrast agent to the patient; and

constructing an image of the artery by subtracting the image data of the pre-contrast image data set from the image data acquired while the concentration of the contrast agent in the artery is substantially greater than a concentration of the contrast agent in veins and background tissue adjacent to the artery.

22. The method of claim 15 further including imaging at least one renal artery of the patient by collecting image data while the concentration of the contrast agent in the renal artery is substantially greater than a concentration of the contrast agent in veins and background tissue adjacent to the renal artery.

23. The method of claim 15 wherein administering the magnetic resonance contrast agent to the patient includes infusing the contrast agent to the patient at a rate which is greater than 0.0015 liters/kilogram-second² divided by the relativity of the contrast agent.

24. The method of claim 15 further including monitoring the region of interest to determine an arrival of the contrast agent in the region of interest.

25. A method of imaging an abdominal artery of a patient using a magnetic resonance imaging system and an administered magnetic resonance contrast agent, the method comprising:

determining an arrival of the magnetic resonance contrast agent in a region of interest by rapidly imaging the region of interest;

correlating collection of magnetic resonance image data which is representative of the center of k-space based on the arrival of the contrast agent in the region of interest; and

collecting image data which is representative of the center of k-space while a concentration of the contrast in the artery is substantially greater than a concentration of the contrast agent in veins and background tissue adjacent to the artery.

26. The method of claim 25 wherein collecting image data which is representative of the center of k-space includes collecting the image data substantially at the beginning of an imaging sequence.

27. The method of claim 25 further including monitoring the region of interest to determine an arrival of the contrast agent in the region of interest.

28. The method of claim 25 further including administering the magnetic resonance contrast agent to the patient in a bolus type injection and wherein collecting image data further includes collecting image data of a 3D gradient echo pulse sequence substantially at a beginning of the 3D imaging sequence.

29. The method of claim 25 wherein collecting image data includes collecting a substantial portion of the image data while the patient suspends respiration.

30. The method of claim 25 wherein collecting image data further includes using a TR which is less than about 25 milliseconds and a TE which is less than about 7 milliseconds.

31. The method of claim 25 wherein collecting image data further includes using a TR which is less than about 10 milliseconds, a TE which is less than about 7 milliseconds, and a flip angle which is between about 30°

and about 90°

.

32. The method of claim 25 further including imaging at least one renal artery of the patient by collecting image data using a 3D gradient echo pulse sequence and coronally oriented image volume wherein the image volume includes at least a portion of the renal artery, the image data being collected while the concentration of the contrast agent in the renal artery is substantially greater than a concentration of the contrast agent in veins and background tissue adjacent to the renal artery.

33. The method of claim 25 further including imaging at least one renal artery of the patient by collecting image data which is representative of the center of k-space while the concentration of the contrast agent in the renal artery is substantially greater than a concentration of the contrast agent in veins and background tissue adjacent to the renal artery.

34. The method of claim 25 further including:

collecting image data of a pre-contrast image data set including collecting image data before administering a substantial amount of the magnetic resonance contrast agent to the patient; and

constructing an image of the artery by subtracting the image data of the pre-contrast image data set from the image data acquired while the concentration of the contrast agent in the artery is substantially greater than a concentration of the contrast agent in veins and background tissue adjacent to the artery.