Apparatus and method for localizing an object in a turbid medium

• US 6,230,045 B1
• Filed: 11/20/1998
• Issued: 05/08/2001
• Est. Priority Date: 11/22/1997
• Status: Expired due to Term

• Current Assignee: US Philips Corporation (Koninklijke Philips N.V.)
• Original Assignee: US Philips Corporation (Koninklijke Philips N.V.)
• Inventors: Hoogenraad, Johannes H., Paasschens, Jeroen C. J., 't Hooft, Gert W.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US09/197,310
• Time in Patent Office: 900 Days
• Field of Search: 600/310, 600/473, 600/476, 356/432-435, 250/339.06, 250/339.09, 250/339.12, 250/341.1, 250/338.1
• US Class Current: 600/473
• CPC Class Codes: A61B 5/0091 for mammography
• CPC Class Codes: A61B 5/4312 Breast evaluation or disorder diagnosis A61B5/0091 takes precedence
• CPC Class Codes: G01N 21/4795 spatially resolved investigating of object in scattering medium in vivo A61B

Abstract

The invention relates to a method of localizing an object in a turbid medium. The invention also relates to a device for carrying out such a method. The method can be used in optical mammography during which a part of a breast of a female body is examined by means of light. To this end, the part of the breast is introduced into a holder of the device, said holder being provided with light sources and detectors. In order to realize an optical coupling between the light sources and the detectors and the breast, a calibration medium is introduced. After measurement of the intensities for a plurality of light paths between the light sources and the detectors, the measured intensity is normalized. In order to counteract artifacts which are caused by deviations of the optical properties of the calibration medium and the mean optical properties of the part of the breast, according to the invention the measured intensities are corrected prior to the reconstruction of the interior of the breast. The corrected intensity for a light path to be selected between a light source and a detector is determined by a combination of a normalized intensity of the selected light path, the normalized intensities, lengths of the light paths, and a length of the selected light path.

Claims

1. A method of localizing an object in a turbid medium, comprising:

immersing the turbid medium in a calibration medium,

irradiating the turbid medium,

measuring intensities of a part of light transported through the turbid medium and the calibration medium along a plurality of light paths,

normalizing the measured intensities,

performing a correction on the normalized intensities to realize corrected normalized intensities by generating a corrected normalized intensity of each selected light path including combining a normalized intensity of a selected light path, the normalized intensities, lengths of the light paths, and a length of the selected light path, and

reconstructing an image of the interior of the turbid medium utilizing the corrected normalized intensities.

2. A method as claimed in claim 1 wherein the value of the combination comprises a function of the length of the selected light path and a derivative of the normalized intensity to the length of the light path.

3. A method as claimed in claim 2, characterized in that the value of the combination contains a first constant which is determined by a distance between a point of intersection of a reference line and a first axis of a graph relative to an origin of the graph, the reference line representing a logarithm of a ratio of a measured intensity of the calibration medium to a measured intensity of a reference medium.

4. The method of claim 2 wherein the normalized intensity of a light path to be selected is determined by a logarithm of a ratio of a first intensity of a selected light path in the turbid medium and the calibration medium to a second intensity of the selected light path in the calibration medium.

5. The method of claim 4 wherein the reconstructed image is corrected for the calibration medium by adding a constant to attenuation coefficients of voxels of the turbid medium, which voxels correspond to pixels of the reconstructed image.

6. The method of claim 2 wherein the reconstructed image is corrected for the calibration medium by adding a constant to attenuation coefficients of voxels of the turbid medium, which voxels correspond to pixels of the reconstructed image.

7. A method as claimed in claim 1 wherein the normalized intensity of a light path to be selected is determined by a logarithm of a ratio of a first intensity of a selected light path in the turbid medium and the calibration medium to a second intensity of the selected light path in the calibration medium.

8. The method of claim 7 wherein the reconstructed image is corrected for the calibration medium by adding a constant to attenuation coefficients of voxels of the turbid medium, which voxels correspond to pixels of the reconstructed image.

9. A method as claimed in claim 1 wherein the reconstructed image is corrected for the calibration medium by adding a second constant to attenuation coefficients of voxels of the turbid medium, which voxels correspond to pixels of the reconstructed image.

10. A device for the imaging of objects in a turbid medium comprising:

a holder for receiving a calibration medium and for receiving the turbid medium,

a light source for irradiating the turbid medium and the calibration medium,

means for coupling the light to be generated by the light source into the turbid medium from different angles,

a plurality of photodetectors for measuring the light transported through the turbid medium and the calibration medium in different directions,

means for selecting a photodetector from among the plurality of photodetectors,

a control device for generating control signals for the means for coupling the light into at least one of the calibration medium and the turbid medium from different light paths and for selecting one of the photodetectors,

means for normalizing measured intensities of each light path, to provide normalized intensities,

a control unit for reconstructing an image of the interior of the turbid medium, and

correction means for performing a correction on each of the normalized intensities corresponding to each light path to generate corrected normalized intensities, wherein each corrected normalized intensity of each light path selected is determined by a combining a normalized intensity of the selected light path, the normalized intensities, lengths of the light paths, and a length of the selected light path, wherein said control unit utilizes the corrected normalized intensities to reconstruct said image.