Multi-phasic microphotodiode retinal implant and adaptive imaging retinal stimulation system

• US 6,230,057 B1
• Filed: 03/26/1998
• Issued: 05/08/2001
• Est. Priority Date: 06/06/1995
• Status: Expired due to Term

• Current Assignee: Pixium Vision SA
• Original Assignee: Optobionics Corporation
• Inventors: Chow, Alan Y., Chow, Vincent
• Primary Examiner(s): Schaetzle, Kennedy
• Application Number:
  US09/100,336
• Time in Patent Office: 1,139 Days
• Field of Search: 607/54, 607/116, 607/148, 607/53, 623/4, 623/4.1
• US Class Current: 607/54
• CPC Class Codes: A61F 9/08 Devices or methods enabling eye-patients to replace direct visual perception by another kind of perception
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0543 Retinal electrodes
• CPC Class Codes: A61N 1/36046 of the eye

Abstract

An artificial retina device and a method for stimulating and modulating its function is disclosed. The artificial retina device is comprised of plural multi-phasic microphotodiode subunits. In persons suffering from blindness due to outer retinal layer damage, a plurality of such devices, when surgically implanted into the subretinal space, may allow useful formed artificial vision to develop. One device, called a MMRI-4, transduces light into electric currents to stimulate the retina. The four microphotodiode subunits of the MMRI-4 are oriented so that each flattened sides of the MMRI-4 has two subunits in a PiN configuration and two subunits in a NiP configuration. Filter layers disposed on the PiN configuration will allow visible light to induce a PiN current, and filter layers disposed on the NiP configuration will allow infrared light to induce a NiP current. By projecting real or computer controlled visible light images, and computer controlled infrared light images or illumination, simultaneously or in rapid alternation onto the MMRI-4s, the nature of induced retinal images may be modulated and improved. An Adaptive Imaging Retinal Stimulation System (AIRES), with a Projection and Tracking Optical System (PTOS), which may be worn as a headset is used for this purpose, and is also disclosed. Color images may even be induced by programming the stimulating pulse durations and frequencies of the AIRES system.

Claims

1. A retinal implant for electrically inducing formed vision in the eye, comprising a PiN microphotodiode having a P-side and an N-side where the P-side of the retinal implant has a light filter layer that selectively permits a first selected bandwidth of light to pass, and where the N-side of the retinal implant has a light filter layer that selectively permits a second selected bandwidth of it to pass whereby the retinal implant can stimulate the retina regardless of whether the P-side or the N-side is oriented toward light incident to the eye.

2. The retinal implant of claim 1 wherein the N-side and the P-side filter layers selectively permit substantially the same bandwidth to pass.

3. The retinal implant of claim 2 wherein the N-side light filter layer is a dielectric filter that allows 740 nm to 900 nm to pass.

4. The retinal implant of claim 3 wherein the P-side light filter layer is a dielectric filter that allows 740 nm to 900 nm to pass.

5. The retinal implant of claim 2 wherein the N-side light filter layer is a dielectric filter that allows 400 nm to 740 nm to pass.

6. The retinal implant of claim 5 wherein the P-side light filter layer is a dielectric filter that allows 400 nm to 740 nm to pass.

7. The retinal implant of claim 1 wherein the N-side and the P-side filter layers selectively permit substantially different bandwidth to pass.

8. The retinal implant of claim 7 wherein the N-side light filter layer is a dielectric filter that allows 740 nm to 900 nm to pass.

9. The retinal implant of claim 8 wherein the P-side light filter layer is a dielectric filter that allows 400 nm to 740 nm to pass.

10. The retinal implant of claim 7 wherein the N-side light filter layer is a dielectric filter that allows 400 nm to 740 nm to pass.

11. The retinal implant of claim 10 wherein the P-side light filter layer is a dielectric filter that allows 740 nm to 900 nm to pass.

12. The retinal implant of claim 1 wherein the PiN microphotodiode contains (1) a P-electrode made of P-doped polysilicon, (2) a P-side light filter dielectric layer, (3) a P+ layer, (4) an intrinsic layer, (5) a N-type silicon substrate, (6) a N+ layer, (7) a N-side light filter dielectric layer, and (8) a N electrode made of a N-doped polysilicon.

13. The retinal implant of claim 12 wherein the retinal implant further comprises a first electrical contact pad that establishes electrical contact between the P-electrode and the P+ layer, and a second electrical contact pad that establishes electrical contact between the N-electrode and the N+ layer.

14. The retinal implant of claim 1 wherein the retinal implant comprises two of said PiN microphotodiodes, each of the microphotodiodes having an opposite orientation from the other such that when implanted in the eye, the P-side of one microphotodiode will face incident light, and the N-side of the other microphotodiode will face incident light.

15. The retinal implant of claim 12 wherein, the P-electrode projects outwardly from a surface of the retinal implant.

16. The retinal implant of claim 12 wherein the N-electrode projects outwardly from the surface of the retinal implant.

17. The retinal implant of claim 15 wherein the N-electrode projects outwardly from the surface of the retinal implant.

18. The retinal implant of claim 17 wherein each of the P-electrode and N-electrode projects from about 1 micron to about 200 microns.

19. The retinal implant of claim 18 wherein each of the P-electrode and N-electrode projects from about 2 micron to about 100 microns.

20. The retinal implant of claim 14 wherein a common electrode is in electrical contact with both the P-side and the N-side on one side of the retinal implant and another common electrode is in electrical contact with both the P-side and the N-side on the other side of the retinal implant.

21. The retinal implant of claim 20 wherein a plurality of the retinal implants are fabricated upon a common silicon substrate wafer.

22. The retinal implant of claim 21 wherein the common silicon substrate wafer has a beveled edge.

29. The retinal implant of claim 1, wherein the PiN microphotodiode comprises:

a P-electrode;

a P-side light filter dielectric disposed adjacent to, and in contact with, the P-electrode;

a P+ layer disposed adjacent to, and in contact with, the P-side light filter dielectric;

an intrinsic layer disposed adjacent to, and in contact with, the P+ layer;

an N-type silicon substrate disposed adjacent to, and in contact with, the intrinsic layer;

an N+type layer disposed adjacent to, and in contact with, the N-type silicon substrate;

an N-side light filter dielectric layer disposed adjacent to, and in contact with, the N+ layer; and

an N-electrode disposed adjacent to, and in contact with, the N-side light filter dielectric layer.

30. The retinal implant of claim 29, wherein the P-electrode comprises iridium oxide.

31. The retinal implant of claim 29, wherein the N-electrode comprises iridium oxide.

33. The retinal implant of claim 1, wherein the P-side and the N-side each further comprise an electrode constructed of iridium oxide.

37. The retinal implant of claim 1, wherein the P-side and the N-side each further comprise an electrode comprising a compound constructed of a material selected from a group consisting of iridium, platinum, aluminum, ruthenium, rhodium, palladium, tantalum, titanium, chromium, molybdenum, cobalt, nickel, iron, copper, silver, zirconium, tungsten, and polysilicon.

23. A retinal implant comprising two groups of microphotoelectric subunits formed on a substrate, the two groups being of opposite orientation:

a first group of at least one PiN subunit, and a second group of at least one NiP subunit, each of the subunits having a P+ layer and an N+ layer, such that the P+ layer of the first group is adjacent the N+ layer of the second group.

24. The retinal implant of claim 23 further comprising a first common electrode contacting the P+ layer of at least one of the subunits of the first group to the N+ layer of a second group subunit, and a second common electrode contacting the N+ layer of at least one of the subunits in the first group to the P+ layer of a second group subunit.

25. The retinal implant of claim 24 wherein each PiN subunit is paired with an NiP subunit, and each paired PiN/NiP subunit combination has a first and second common electrode.

26. The retinal implant of claim 25 comprising plural paired PiN/NiP subunit combinations.

27. The retinal implant of claim 26 wherein the plural paired PiN/NiP subunit combinations are on a substrate from 1 micron to 0.25 mm in width.

28. The retinal implant of claim 26 wherein the plural paired PiN/NiP subunit combinations are on a substrate from 0.25 mm to 15 mm in width.

32. The retinal implant of claim 24, wherein at least one of the first and second common electrodes comprises iridium oxide.

34. A retinal implant for electrically inducing formed vision in the eye, comprising a PiN microphotodiode having a P-side and an N-side where the P-side of the retinal implant has a light filter layer that selectively permits a selected bandwidth of the ultraviolet, visible, and infrared spectrum to pass, and where the N-side of the retinal implant has a light filter layer that selectively permits a selected bandwidth of the ultraviolet, visible, and infrared spectrum to pass, wherein the retinal implant comprises two of said PiN microphotodiodes, each of the microphotodiodes having an opposite orientation from the other such that when implanted in the eye, the P-side of one microphotodiode will face incident light, and the N-side of the other microphotodiode will face incident light and wherein a common electrode is in electrical contact with both the P-side and the N-side on one side of the retinal implant and another common electrode is in electrical contact with both the P-side and the N-side on the other side of the retinal implant, whereby the retinal implant can stimulate the retina regardless of whether the P-side or the N-side is oriented toward light incident to the eye.

35. The retinal implant of claim 34 wherein a plurality of the retinal implants are fabricated upon a common silicon substrate wafer.

36. The retinal implant of claim 35 wherein the common silicon substrate wafer has a beveled edge.