Contrast agent for ultrasonic imaging

• US 6,231,513 B1
• Filed: 10/14/1998
• Issued: 05/15/2001
• Est. Priority Date: 10/14/1998
• Status: Expired due to Term

• Current Assignee: Invivo Germany GmbH
• Original Assignee: Daum Gmbh
• Inventors: Kloess, Wolfgang, Daum, Wolfgang
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): PATEL, MAULIN M
• Application Number:
  US09/172,387
• Time in Patent Office: 944 Days
• Field of Search: 600/458, 600/459, 600/431, 600/420, 604/24, 604/26, 604/509, 754/14, 424/9.52
• US Class Current: 600/458
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/418 lymph vessels, ducts or nodes
• CPC Class Codes: A61B 8/06 Measuring blood flow measuring volume flow in general G01F, e.g. G01F1/66, G01F1/72; measuring speed of fluids in general G01P5/00
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039

Abstract

The present invention is directed to apparatuses and methods for determining blood flow characteristics and imaging interior surface contours within vessel walls. In a preferred embodiment, the method of the invention includes a hollow tubular lumen having a proximal end and distal end wherein the distal end includes a microbubble forming arrangement for forming microbubbles when a gas is passed through the distal end of the hollow tube.

Claims

1. An apparatus for delivering a contrast agent into a vessel comprising:

a tube having a lumen extending from a proximal end to a distal end of the tube; and

a microbubble forming arrangement at the distal end of the lumen having microholes which cause formation of microbubbles when a gas is passed through the microbubble forming arrangement.

2. The apparatus according to claim 1, wherein the tube is a catheter.

3. The apparatus according to claim 1, wherein the tube is a needle.

4. The apparatus according to claim 1, wherein the microbubble forming arrangement is a porous matrix having microholes therethrough.

5. The apparatus according to claim 1, wherein the microbubble forming arrangement is a membrane having microholes therethrough.

6. The apparatus according to claim 4, wherein the porous matrix is of a material selected from the group comprising ceramic, sintered alloy, sintered nickel-titanium and sintered polytetrafluoroethylene.

7. A method for imaging an interior surface of a wall of a vessel, the method comprising a step of:

inserting an apparatus for delivering a contrast agent into the interior of the vessel, wherein the apparatus comprises;

(i) a tube having a lumen extending from a proximal end to a distal end of the tube; and

(ii) a microbubble forming arrangement at the distal end of the lumen having microholes which cause formation of microbubbles when a gas is passed through the microbubble forming arrangement; and

passing a gas through the microbubble forming arrangement at the distal end of the tube to form microbubbles within the interior of the vessel;

imaging the microbubbles passing along the interior surface of the vessel wall using an ultrasound imaging instrument.

8. The method according to claim 7, wherein the tube is a catheter.

9. The method according to claim 7, wherein the tube is a needle.

10. The method according to claim 7, wherein the microbubble forming arrangement is a porous matrix having microholes which form microbubbles when a gas is passed therethrough.

11. The method according to claim 7, wherein the microbubble forming arrangement is a membrane having microholes which form microbubbles when a gas is passed therethrough.

12. The method according to claim 10, wherein the porous matrix is of a material selected from the group comprising ceramic, sintered alloy, sintered nickel-titanium and sintered polytetrafluoroethylene.

13. The method according to claim 7 wherein the gas is CO₂.

14. The method according to claim 7 wherein the microbubbles formed are of a size of about 1 μ

m to 50 μ

m.

15. A method for delivering microbubbles to the interior of a vessel, the method comprising a step of:

inserting an apparatus for delivering a contrast agent into the interior of the vessel, wherein the apparatus comprises;

(i) a tube having a lumen extending from a proximal end to a distal end of the tube; and

(ii) a microbubble forming arrangement at the distal end of the lumen having microholes which cause formation of microbubbles when a gas is passed through the cover medium;

passing a gas through the microbubble forming arrangement at the distal end of the tube to form microbubbles within the interior of the vessel.

16. The method according to claim 15 wherein the microbubbles are imaged with ultrasound imaging instrumentation as the microbubbles pass along the interior surface of the vessel wall.

17. The method according to claim 15 wherein a rate of flow of fluid passing through the vessel is measured by calculating the rate of flow of microbubbles that are passed into the interior of the vessel.

18. An apparatus for delivering a contrast agent into a vessel comprising:

a tube having a lumen extending from a proximal end to a distal end of the tube; and

an arrangement for transmitting ultrasound waves to the proximal end of the tube that can create a vibration which causes formation of microbubbles to pass out the distal end of the tube when ultrasound waves are applied to a gas flowing through the tube.