Circulating fluid hypothermia method and apparatus

• US 6,231,595 B1
• Filed: 03/31/1998
• Issued: 05/15/2001
• Est. Priority Date: 03/31/1998
• Status: Expired due to Term

• Current Assignee: Zoll Circulation Incorporated (Asahi Kasei Corporation)
• Original Assignee: Innercool therapies Incorporated (Taxus Cardium Pharmaceuticals Group, Inc.)
• Inventors: Dobak, John D. III
• Primary Examiner(s): Dvorak, Linda C. M.
• Assistant Examiner(s): ROLLINS, ROSILAND STACIE
• Application Number:
  US09/052,545
• Time in Patent Office: 1,141 Days
• Field of Search: 604/113, 604/43, 604/264, 604/280, 607/96, 607/104, 607/105, 607/106, 607/107, 607/113, 607/114, 606/20, 606/21, 606/22
• US Class Current: 607/106
• CPC Class Codes: A61B 2018/0212 using an instrument inserted into a body lumen, e.g. catheter
• CPC Class Codes: A61B 2018/0262 using a circulating cryogenic fluid
• CPC Class Codes: A61F 2007/0056 for cooling
• CPC Class Codes: A61F 2007/126 for invasive application, e.g. for introducing into blood vessels
• CPC Class Codes: A61F 7/12 Devices for heating or cooling internal body cavities

Abstract

A method and apparatus for performing hypothermia of a selected organ without significant effect on surrounding organs or other tissues. A flexible coaxial catheter is inserted through the vascular system of a patient to place the distal tip of the catheter in an artery feeding the selected organ. A chilled perfluorocarbon fluid is pumped through an insulated inner supply conduit of the catheter to cool a flexible bellows shaped heat transfer element in the distal tip of the catheter. The heat transfer bellows cools the blood flowing through the artery, to cool the selected organ, distal to the tip of the catheter.

Claims

1. An apparatus for selective organ hypothermia, said apparatus comprising:

a circulating unit adapted for chilling and circulating a fluid;

a flexible elongated catheter;

a flexible tubular outer catheter body on said catheter;

a flexible, insulated, fluid supply tube within said outer catheter body, a proximal end of a central lumen of said fluid supply tube being connected in fluid flow communication with an outlet of said circulating unit;

a fluid return lumen within said outer catheter body, said fluid return lumen substantially surrounding said fluid supply tube, a proximal end of said fluid return lumen being connected in fluid flow communication with an inlet of said circulating unit;

a flexible heat transfer element mounted to a distal end of said outer catheter body, said heat transfer element having a convoluted surface to increase the surface area available for heat transfer; and

a chamber within said heat transfer element, said chamber being in fluid flow communication with an outlet of said central lumen of said fluid supply tube, said chamber being in fluid flow communication with a distal end of said fluid return lumen within said outer catheter body;

wherein said fluid supply tube comprises a wall having insulating properties to reduce heat transfer from said fluid return lumen to said central lumen of said fluid supply tube.

2. An apparatus as recited in claim 1, wherein said heat transfer element comprises a bellows shape.

3. An apparatus as recited in claim 2, wherein said bellows comprises a plurality of annular folds.

4. An apparatus as recited in claim 1, further comprising an antithrombogenic agent bonded to an outer surface of said heat transfer element.

5. An apparatus as recited in claim 1, wherein said fluid supply tube comprises a single wall tube, further comprising a plurality of longitudinal channels formed longitudinally within the wall of said fluid supply tube, said longitudinal channels being configured and arranged to substantially surround said central lumen of said fluid supply tube, thereby insulating said central lumen of said fluid supply tube from said fluid return lumen.

6. An apparatus as recited in claim 5, wherein said longitudinal channels are filled with an entrapped gas.

7. An apparatus as recited in claim 5, wherein said longitudinal channels are evacuated and sealed.

8. An apparatus as recited in claim 1, wherein said outer catheter body comprises a wall having insulating properties.

9. An apparatus as recited in claim 8, wherein said outer catheter body comprises a single wall tube, further comprising a plurality of longitudinal channels formed longitudinally within the wall of said outer catheter body, said longitudinal channels being configured and arranged to substantially surround said fluid return lumen of said outer catheter body, thereby insulating said fluid return lumen from the environment surrounding said outer catheter body.

10. An apparatus as recited in claim 9, wherein said longitudinal channels are filled with an entrapped gas.

11. An apparatus as recited in claim 9, wherein said longitudinal channels are evacuated and sealed.

12. A cooling apparatus, comprising:

a circulating unit adapted for chilling and circulating a perfluorocarbon fluid;

a flexible elongated catheter;

a flexible tubular outer catheter body on said catheter;

a flexible, insulated, perfluorocarbon supply tube within said outer catheter body, a proximal end of a central lumen of said perfluorocarbon supply tube being connected in fluid flow communication with an outlet of said circulating unit;

a perfluorocarbon return lumen within said outer catheter body, said perfluorocarbon return lumen substantially surrounding said fluid supply tube, a proximal end of said perfluorocarbon return lumen being connected in fluid flow communication with an inlet of said circulating unit;

a flexible heat transfer element mounted to a distal end of said outer catheter body, said heat transfer element having a convoluted surface to increase the surface area available for heat transfer; and

a chamber within said heat transfer element, said chamber being in fluid flow communication with an outlet of said central lumen of said perfluorocarbon supply tube, said chamber being in fluid flow communication with a distal end of said perfluorocarbon return lumen within said outer catheter body;

wherein said fluid supply tube comprises a wall having insulating properties to reduce heat transfer from said perfluorocarbon return lumen to said central lumen of said fluid supply tube.