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Aldehyde and glycosidase-treated soft and bone tissue xenografts

  • US 6,231,608 B1
  • Filed: 02/11/1999
  • Issued: 05/15/2001
  • Est. Priority Date: 06/07/1995
  • Status: Expired due to Term
First Claim
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1. A method of preparing a xenograft formed of a soft or bone tissue for implantation into a human, which comprisesa. removing at least a portion of the soft or bone tissue from a non-human animal to provide a xenograft;

  • b. washing the xenograft in water and alcohol;

    c. subjecting the xenograft to a cellular disruption treatment;

    d. exposing the xenograft to an aldehyde in an amount ranging from about 0.01% to about 0.10%; and

    e. digesting the xenograft with a glycosidase to remove substantially a plurality of first surface carbohydrate moieties from the xenograft whereby the xenograft is substantially non-immunogenic and has substantially the same mechanical properties as the native soft or bone tissue.

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