Biocompatible devices with foam scaffolds
First Claim
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1. A method of manufacturing an implantable, biocompatible cell encapsulation device comprising:
- (a) forming a jacket comprising a permeable biocompatible material;
(b) loading the jacket with a core comprising a reticulate foam scaffold having interconnected pores, the pore density of the foam varying between 20%-90%, the core further comprising a population of living mammalian cells dispersed in the pores;
(c) sealing the jacket;
wherein the jacket provides at least one permeable membrane surface which permits passage of biologically active substances across said membrane while preventing passage of mammalian cells thereacross.
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Abstract
This invention is directed to methods of manufacturing implantable biocompatible cell encapsulation devices, wherein the cell encapsulation devices have a jacket made of a permeable, biocompatible material that is loaded with a core made of a reticulate foam scaffold having interconnected pores, with cells that are dispersed in the interconnected pores.
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Citations
8 Claims
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1. A method of manufacturing an implantable, biocompatible cell encapsulation device comprising:
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(a) forming a jacket comprising a permeable biocompatible material;
(b) loading the jacket with a core comprising a reticulate foam scaffold having interconnected pores, the pore density of the foam varying between 20%-90%, the core further comprising a population of living mammalian cells dispersed in the pores;
(c) sealing the jacket;
wherein the jacket provides at least one permeable membrane surface which permits passage of biologically active substances across said membrane while preventing passage of mammalian cells thereacross. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
(i) forming a core within the jacket, the core comprising a reticulate foam scaffold having interconnected pores, the pore density of the foam varying between 20%-90%; and
(ii) loading the core with a population of living mammalian cells.
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Specification