Treatment of HIV by administration of β-D-2′, 3′-didehydro-2′,3′-dideoxy-5-fluorocytidine (D4FC)
First Claim
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1. A method for treating a host infected with human immunodeficiency virus comprising administering an effective amount of β
- -D-2′
,3′
-dideoxy-2′
,3′
-didehydro-5-fluorocytidine (D4FC) or a pharmaceutically acceptable salt thereof.
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Abstract
A method and composition for the treatment of HIV and HBV infections in humans and other host animals is disclosed that includes the administration of an effective amount of a [5-carboxamido or 5-fluoro]-2′,3′-dideoxy-2′,3′-didehydro-pyrimidine nucleoside or a [5-carboxamido or 5-fluoro]-3′-modified-pyrimidine nucleoside, or a mixture or a pharmaceutically acceptable derivative thereof, including a 5′ or N4 alkylated or acylated derivative, or a pharmaceutically acceptable salt thereof, in a pharmaceutically acceptable carrier.
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Citations
10 Claims
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1. A method for treating a host infected with human immunodeficiency virus comprising administering an effective amount of β
- -D-2′
,3′
-dideoxy-2′
,3′
-didehydro-5-fluorocytidine (D4FC) or a pharmaceutically acceptable salt thereof. - View Dependent Claims (2)
- -D-2′
-
3. A method for treating a host infected with human immunodeficiency virus comprising administering an effective amount of β
- -D-2′
,3′
-dideoxy-2′
,3′
-didehydro-5-fluorocytidine (D4FC) or a pharmaceutically acceptable salt, ester, or the 5′
-mono, di or tri phosphate thereof, optionally in combination with a pharmaceutically acceptable carrier. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10)
- -D-2′
Specification