Antibody immunoreactive with a human cytokine designated LERK-6

• US 6,232,447 B1
• Filed: 10/15/1998
• Issued: 05/15/2001
• Est. Priority Date: 10/05/1994
• Status: Expired due to Fees

• Current Assignee: Immunex Corporation (Amgen Inc.)
• Original Assignee: Immunex Corporation (Amgen Inc.)
• Inventors: Cerretti, Douglas P.
• Primary Examiner(s): Draper, Garnette D.
• Application Number:
  US09/173,133
• Time in Patent Office: 943 Days
• Field of Search: 530/388.23, 530/389.2, 424/145.1, 424/158.1, 435/70.2, 435/70.21
• US Class Current: 530/388.23
• CPC Class Codes: A01K 2217/05 Animals comprising random inserted nucleic acids (transgenic)
• CPC Class Codes: A61F 2013/00153 coloured or with decoration pattern or printing
• CPC Class Codes: C07K 14/52 Cytokines; Lymphokines; Interferons
• CPC Class Codes: C07K 16/20 from protozoa
• CPC Class Codes: C07K 2319/00 Fusion polypeptide

Abstract

The invention is directed to antibodies immunoreactive with a Human LERK-6 as a purified and isolated protein, the DNA encoding the LERK-6, host cells transfected with cDNAs encoding LERK-6.

Claims

1. An antibody that is immunoreactive with a LERK-6 polypeptide that binds hek/elk, wherein said polypeptide comprises amino acids 1 to 104 of SEQ ID NO:

8.

5. The antibody of claim 1, wherein said polypeptide is encoded by a DNA molecule comprising nucleotides 2 to 313 of SEQ ID NO:

7.

9. The antibody according to claim 1, wherein said antibody is a monoclonal antibody.

13. The antibody according to claim 5, wherein said antibody is a monoclonal antibody.

2. An antibody that is immunoreactive with a LERK-6 polypeptide that binds hek/elk, wherein said polypeptide comprises amino acids 1 to 185 of SEQ ID NO:

10.

6. The antibody of claim 2, wherein said polypeptide is encoded by a DNA molecule comprising nucleotides 88 to 642 of SEQ ID NO:

9.

10. The antibody according to claim 2, wherein said antibody is a monoclonal antibody.

14. The antibody according to claim 6, wherein said antibody is a monoclonal antibody.

3. An antibody that is immunoreactive with a LERK-6 polypeptide that binds hek/elk, wherein said polypeptide comprises amino acids 1 to 145 of SEQ ID NO:

10.

7. The antibody of claim 3, wherein said polypeptide is encoded by a DNA molecule comprising nucleotides 88 to 522 of SEQ ID NO:

9.

11. The antibody according to claim 3, wherein said antibody is a monoclonal antibody.

15. The antibody according to claim 7, wherein said antibody is a monoclonal antibody.

4. An antibody that is immunoreactive with a LERK-6 polypeptide that binds hek/elk, wherein said polypeptide comprises amino acids 1 to 134 of SEQ ID NO:

10.

8. The antibody of claim 4, wherein said polypeptide is encoded by a DNA molecule comprising nucleotides 88 to 489 of SEQ ID NO:

9.

12. The antibody according to claim 4, wherein said antibody is a monoclonal antibody.

16. The antibody according to claim 8, wherein said antibody is a monoclonal antibody.