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Optimization systems in a scanning fluorometer

  • US 6,232,608 B1
  • Filed: 03/23/1999
  • Issued: 05/15/2001
  • Est. Priority Date: 08/18/1998
  • Status: Expired due to Term
First Claim
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1. A method of obtaining a wide dynamic range in a scanning fluorometer, the method comprising the steps of:

  • multiplexing an output from a photomultiplier tube detector in said scanning fluorometer through a plurality of gain amplifiers, each of said plurality of gain amplifiers providing a different level of gain, wherein said plurality of gain amplifiers includes a high gain amplifier providing the highest gain of said plurality of gain amplifiers;

    determining a maximum photomultiplier tube detector supply voltage, wherein said maximum photomultiplier tube detector supply voltage provides an output signal from said high gain amplifier near a maximum value for a low reference; and

    determining at least one additional photomultiplier tube detector supply voltage, wherein said at least one additional photomultiplier tube detector supply voltage is lower than said maximum photomultiplier tube detector supply voltage.

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