Determining body composition using fan beam dual-energy x-ray absorptiometry

• US 6,233,473 B1
• Filed: 04/15/1999
• Issued: 05/15/2001
• Est. Priority Date: 02/16/1999
• Status: Expired due to Term

• Current Assignee: Hologic Incorporated
• Original Assignee: Hologic Incorporated
• Inventors: Kelly, Thomas L., Shepherd, John A.
• Primary Examiner(s): MANUEL, GEORGE C
• Application Number:
  US09/292,480
• Time in Patent Office: 761 Days
• Field of Search: 600/407, 600/408, 378/4, 378/21, 378/37, 378/53, 378/54, 378/98.9, 374/45, 514/556
• US Class Current: 600/407
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/4035 the source being combined with a filter or grating
• CPC Class Codes: A61B 6/405 Source units specially adapted to modify characteristics of the beam during the data acquisition process A61B6/4021, A61B6/4035 take precedence
• CPC Class Codes: A61B 6/4241 using energy resolving detectors, e.g. photon counting
• CPC Class Codes: A61B 6/482 involving multiple energy imaging
• CPC Class Codes: A61B 6/505 for diagnosis of bone
• CPC Class Codes: A61B 6/508 for non-human patients
• CPC Class Codes: A61B 6/583 using calibration phantoms

Abstract

True body composition is estimated using a dual-energy, fan-shaped distribution of x-rays and signal processing that corrects for mass magnification and other effects due to the geometry of the measurement system. To avoid inaccuracies due to beam hardening and certain other effects, the thickness of attenuating material along respective raypaths is obtained through using a four-dimensional look-up table derived experimentally from step-wedge measurements. To correct for mass magnification effects due to using a fan-shaped distribution of x-rays, another look-up table and interpolation between table entries are used to convert projected mass to true mass.

Claims

1. A method of estimating body composition from x-ray measurements made with a fan-shaped distribution of x-rays comprising the steps of:

scanning a body with a fan-shaped distribution of x-rays and with a detector of x-rays to derive dual-energy x-ray measurements for respective pixel positions conforming to a two dimensional projection of the body;

processing the x-ray measurements to derive estimates of projected body mass for the respective pixel positions;

further processing the estimates of projected body mass to derive estimates of true body mass for the respective pixel positions that account for the positions of attenuating material along raypaths from a source of the x-ray distribution to respective positions at the detector.

2. A method as in claim 1 in which said processing comprises relating x-ray measurements to estimates of projected body mass by utilizing a computer implementation of an experimentally derived first look-up table relating dual-energy x-ray measurements, density and body thickness for the respective pixel positions.

3. A method as in claim 2 in which said further processing comprises relating the estimates of projected body mass to true body mass using a computer implementation of a second experimentally derived look-up table and interpolating between entries in said second look-up table as needed for values intermediate entries in said second look-up table.

4. A method as in claim 3 including the step of defining a region of interest in said body and using said estimates of true body mass for the pixel positions matching the region of interest to derive a total body mass estimate for the region of interest.

5. A method as in claim 4 in which the step of defining a region of interest comprises interactively defining the region from user input showing the region of interest on a displayed image of the body.