Ischemia detector and heart stimulator provided with such an ischemia detector

• US 6,233,486 B1
• Filed: 07/20/1999
• Issued: 05/15/2001
• Est. Priority Date: 01/22/1997
• Status: Expired due to Fees

• Current Assignee: Pacesetter AB
• Original Assignee: Pacesetter AB
• Inventors: Nyhlén, Christina, Ekwall, Christer
• Primary Examiner(s): Nasser, Robert L.
• Application Number:
  US09/341,944
• Time in Patent Office: 665 Days
• Field of Search: 607/17, 607/23, 600/481, 600/485
• US Class Current: 607/17
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61M 2025/0002 with a pressure sensor at the distal end
• CPC Class Codes: A61M 2210/125 Heart
• CPC Class Codes: A61N 1/36564 controlled by blood pressure

Abstract

An ischemia detector has a sensor unit which determines the systolic pressure of a subject, a unit wherein a relation is established between the systolic pressure and the subject'"'"'s heart rate, as the heart rate is varied over a range, and an analyzer which determines the occurrence of ischemia from this relation.

Claims

1. An ischemia detector, comprising a sensor unit which emits a signal representing systolic pressure of a subject, means for establishing a relation between said systolic pressure and a heart rate of a subject over a plurality of varying heart rates, and analyzer means for determining an occurrence of ischemia from said relation.

2. The detector according to claim 1, wherein said analyzer means identifies a decreasing systolic pressure with increasing heart rate as an occurrence of ischemia.

3. The detector according to claim 2 wherein said analyzer means comprise comparator means for comparing the systolic pressure from one heartbeat to the systolic pressure from a next heartbeat to determine whether a relationship of heartbeat-to-heartbeat systolic pressures exists that is indicative of ischemia.

4. The detector according to claim 1 wherein said analyzer means identifies a decreasing systolic pressure with increasing heart rate followed by an increasing systolic pressure with decreasing heart rate as an occurrence of ischemia.

5. The detector according to claim 4, wherein said analyzer means comprise comparator means for comparing the systolic pressure from one heartbeat to the systolic pressure from a next heartbeat to determine whether a relationship of heartbeat-to-heartbeat systolic pressures exists that is indicative of ischemia.

6. The detector according to claim 1 wherein said sensor unit measures the systolic pressure in the right ventricle of a subject.

7. The detector according to claim 1 further comprising an alerting unit which is activated in response to a detected occurrence of ischemia.

8. The detector according to claim 7, wherein said alerting device is activated by said analyzer means in response to a detected occurrence of ischemia.

9. An ischemia detector comprising a sensor unit which determines a pressure difference between an end systolic pressure and an end diastolic pressure of a subject, means for establishing a relation between said pressure difference a heart rate of a subject when over a plurality of heart rates, and analyzer means for determining an occurrence of ischemia from said relation.

10. The detector according to claim 9 further comprising an alerting unit which is activated in response to a detected occurrence of ischemia.

11. The detector according to claim 10 wherein said alerting unit is activated by said analyzer means in response to a detected occurrence of ischemia.

12. A heart stimulator comprising:

a pulse generator which emits stimulation pulses at a stimulation rate;

an electrode lead connected to said pulse generator and adapted for in vivo implantation in a subject to deliver said stimulation pulses to cardiac tissue, said electrode lead having at least one electrode adapted for contact with cardiac tissue;

means for operating said stimulation generator to vary said pulse rate over a plurality of stimulation rates; and

an ischemia detector comprising a sensor unit which emits a signal representing systolic pressure of a subject receiving said stimulation pulses, means for establishing a relation between said systolic pressure and a heart rate of a subject over a plurality of heart rates represented by said plurality of stimulation rates, and analyzer means for determining an occurrence of ischemia from said relation.

13. The heart stimulator according to claim 12 wherein said at least one electrode comprises a tip electrode and wherein said sensor unit comprises a sensor mounted behind the electrode tip on said electrode lead.

14. The heart stimulator according to claim 12 further comprising a control unit for controlling said pulse generator in a rate responsive mode and wherein said analyzer means is connected to said control unit to disable the rate responsive mode as soon as an increased stimulation rate does not result in an increased systolic pressure.

15. The heart stimulator according to claim 12 further comprising control means connected to the ischemia detector for controlling the stimulation rate varying means to lower the stimulation rate in response to a detection of an occurrence of ischemia.

16. The heart stimulator according to claim 15, wherein said control means control said stimulation rate varying means to lower the stimulation rate to a maximum stimulation rate for which an occurrence of ischemia is not detected.

17. The heart stimulator according to claim 15, wherein said control means control said stimulation rate varying means to lower the stimulation rate to a base rate, below a stimulation rate at which an occurrence of ischemia is detected.

18. A heart stimulator comprising:

a pulse generator which emits stimulation pulses at a stimulation rate;

an electrode lead connected to said pulse generator and adapted for in vivo implantation in a subject to deliver said stimulation pulses to cardiac tissue, said electrode lead having at least one electrode adapted for contact with cardiac tissue;

means for operating said stimulation generator to vary said pulse rate over a plurality of stimulation rates; and

an ischemia detector comprising a sensor unit which determines a pressure difference between an end systolic pressure and an end diastolic pressure of a subject, means for establishing a relation between said pressure difference and a heart rate of a subject over a plurality of heart rates represented by said plurality of rates rates, and analyzer means for determining an occurrence of ischemia from said relation.

19. The heart stimulator according to claim 18 wherein said at least one electrode is a tip electrode and wherein said sensor unit comprises a sensor mounted behind the tip electrode on said electrode lead.

20. The heart stimulator according to claim 18 further comprising a control unit for controlling said pulse generator in a rate responsive mode and wherein said analyzer means is connected to said control unit to disable the rate responsive mode as soon as an increased stimulation rate does not result in an increased systolic pressure.

21. The heart stimulator according to claim 18 further comprising control means connected to the ischemia detector for controlling the stimulation rate varying means to lower the stimulation rate in response to a detection of an occurrence of ischemia.

22. The heart stimulator according to claim 21, wherein said control means control said stimulation rate varying means to lower the stimulation rate to a maximum stimulation rate for which an occurrence of ischemia is not detected.

23. The heart stimulator according to claim 21, wherein said control means control said stimulation rate varying means to lower the stimulation rate to a base rate, below a stimulation rate at which an occurrence of ischemia is detected.