Blood component collection system with optimizer

• US 6,233,525 B1
• Filed: 07/26/1999
• Issued: 05/15/2001
• Est. Priority Date: 03/04/1992
• Status: Expired due to Term

• Current Assignee: Terumo BCT, Inc. (Terumo Corporation)
• Original Assignee: Gambro, Inc. (DaVita Incorporated)
• Inventors: Langley, Robert W., Keller, John J., Urdahl, Steven Gage
• Primary Examiner(s): WACHSMAN, HAL D
• Application Number:
  US09/361,098
• Time in Patent Office: 659 Days
• Field of Search: 702/21, 702/19, 702/22, 702/30, 702/45, 702/50, 702/100, 702/FOR-115, 702/FOR.121, 702/FOR.127, 702/FOR.128, 702/FOR.170, 702/FOR.171, 604/30, 604/4.01, 604/5-1-, 604/6-1-, 604/6.1, 604/6-1-, 356/39, 356/42, 422/67, 210/645-647, 210/781, 210/782, 210/651, 377/20, 377/21, 436/10, 436/177, 436/63, 436/69, 436/70, 436/174, 435/2, 382/133, 382/134, 700/266, 700/281, 700/282, 700/285, 703/11, 703/12, 600/526
• US Class Current: 702/21
• CPC Class Codes: A61M 1/02 Blood transfusion apparatus blood infusion by syringes A61M5/14
• CPC Class Codes: A61M 1/30 Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
• CPC Class Codes: A61M 1/303 having a reservoir for treated blood to be returned
• CPC Class Codes: A61M 1/307 Time control
• CPC Class Codes: A61M 1/3603 in the same direction
• CPC Class Codes: A61M 1/3609 Physical characteristics of the blood, e.g. haematocrit, urea
• CPC Class Codes: A61M 1/3622 with a cassette forming partially or totally the blood circuit
• CPC Class Codes: A61M 1/3643 Priming, rinsing before or after use
• CPC Class Codes: A61M 1/3672 Means preventing coagulation
• CPC Class Codes: A61M 1/3693 using separation based on different densities of components, e.g. centrifuging
• CPC Class Codes: A61M 1/3696 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: A61M 1/38 Removing constituents from donor blood and storing or returning remainder to body , e.g. for transfusion
• CPC Class Codes: A61M 1/385 taking into account of the patient characteristics
• CPC Class Codes: A61M 1/387 taking into account of the needs or inventory
• CPC Class Codes: A61M 2202/0415 Plasma
• CPC Class Codes: A61M 2202/0427 Platelets; Thrombocytes
• CPC Class Codes: A61M 2205/12 with interchangeable cassettes forming partially or totally the fluid circuit
• CPC Class Codes: A61M 2205/50 with microprocessors or computers

Abstract

A blood component collection system is disclosed with optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameters. Thereafter, the blood component collection procedure is performed with these derived process control parameters. In another embodiment, process parameters are derived from an input total procedure time from a maximized value for at least one of the other process control parameters so as to maximize blood component yield in this fixed time. Thereafter, the blood component collection procedure is performed with these derived parameters.

Claims

1. A method for collecting at least one predetermined type of blood component from a source of whole blood using a blood component collection system comprising at least a blood component collection device, said method comprising the steps of:

providing biological data relating to said source of whole blood;

identifying a desired yield of said at least one predetermined type of blood component;

associating a magnitude with each of one or more control parameters, said one or more control parameters being used in controlling said blood component collection system;

said associating step comprising performing a first deriving step comprising deriving a magnitude for at least one of said one or more control parameters from said providing and identifying steps;

inputting said magnitude of each of said one or more control parameters into said blood component collection system after said associating step; and

performing a collection procedure on said blood component collection device using said inputting step to collect said desired yield of said at least one predetermined type of blood component from said source of whole blood;

wherein;

one of said one or more control parameters is an inlet flow to said blood component collection device and another of said one or more control parameters is a flow of anticoagulant into said blood component collection system, wherein said inlet flow comprises a flow of whole blood from said source of whole blood and said flow of anticoagulant, wherein said source of whole blood has a volume, wherein at least part of said flow of anticoagulant is provided to said source of whole blood, wherein an anticoagulant ratio is a ratio of said inlet flow to said flow of anticoagulant, and wherein an anticoagulant infusion rate is defined by said at least part of said flow of anticoagulant per said volume.

2. The method, as claimed in claim 1, wherein said performing a first deriving step further comprises:

deriving a magnitude of said inlet flow associated with a predetermined magnitude of said anticoagulant infusion rate.

3. The method, as claimed in claim 2, wherein said deriving a magnitude of said inlet flow step comprises:

using said predetermined magnitude of said anticoagulant infusion rate and a current magnitude for a total procedure time, said total procedure time being another of said one or more control parameters.

4. The method as claimed in claim 3, wherein said deriving a magnitude of said inlet flow step further comprises:

assuming a current magnitude for said inlet flow and performing a first iteration procedure comprising calculating a current magnitude for said anticoagulant infusion rate from at least the assumed current magnitude of said inlet flow, evaluating convergence criteria relating to the assumed current magnitude of said inlet flow, and adjusting the assumed current magnitude of said inlet flow to create an adjusted current magnitude of said inlet flow and repeating said first iteration procedure until said convergence criteria is established.

5. The method, as claimed in claim 3, wherein:

said deriving a magnitude of said inlet flow step comprises deriving a current magnitude of said inlet flow and deriving a current magnitude for said anticoagulant infusion rate, said performing a first deriving step further comprising iteratively calculating a current blood component yield using at least said current magnitude of said inlet flow and said current magnitude of said anticoagulant infusion rate and by using said providing step and by iteratively adjusting said current magnitude of said total procedure time until achieving said desired yield of said at least one predetermined type of blood component.

6. The method as claimed in claim 3, wherein:

said deriving a magnitude of said inlet flow step comprises deriving a current magnitude for said anticoagulant infusion rate, said performing a first deriving step further comprising performing a first iteration procedure after said deriving a magnitude of said inlet flow step, said first iteration procedure step comprising calculating a current yield from said magnitude of said inlet flow, said predetermined magnitude of said anticoagulant infusion rate, and said current magnitude of said total procedure time, comparing said current yield with said desired yield, performing said inputting step after said comparing step when said current yield is within a predetermined amount of said desired yield, adjusting said current magnitude of said total procedure time when said current yield differs from said desired yield by more than said predetermined amount, repeating said deriving a magnitude of said inlet flow step after said adjusting said current magnitude of said total procedure time step, and repeating said first iteration procedure step until a predetermined convergence criteria relating to said total procedure time is established.

7. The method, as claimed in claim 6, wherein:

said performing a first deriving step further comprises performing a second iteration procedure after said first iteration procedure step and when said predetermined convergence criteria associated with said first iteration procedure is established, said second iteration procedure step comprising adjusting a magnitude of said anticoagulant ratio, and repeating said first and second iteration procedure steps until a predetermined convergence criteria relating to said magnitude of said anticoagulant ratio is established.

8. The method, as claimed in claim 7, wherein:

said anticoagulant infusion rate is increased by a predetermined amount when said predetermined convergence criteria associated with said second iteration procedure step is established, wherein said performing a first deriving step further comprises repeating said first and second iteration procedure steps using this increased anticoagulant infusion rate.

9. The method, as claimed in claim 3, wherein said performing a first deriving step further comprises deriving a total procedure time after said deriving a magnitude of said inlet flow step which provides a current yield within a predetermined amount of said desired yield, said total procedure time being another of said one or more control parameters.

10. The method, as claimed in claim 1, wherein:

said associating step comprises selecting a maximum magnitude for said anticoagulant infusion rate, and wherein said associating step further comprises generating a calculated magnitude of said inlet flow using at least said maximum magnitude of said anticoagulant infusion rate.

11. The method, as claimed in claim 10, wherein said performing a first deriving step further comprises:

deriving a theoretical magnitude of said inlet flow which provides a maximum yield of said at least one predetermined type of blood component and comparing said theoretical and calculated magnitudes of said inlet flow, and wherein said inputting step comprises inputting the lesser of said theoretical magnitude and said calculated magnitude of said inlet flow.

12. The method, as claimed in claim 11, wherein:

another of said one or more control parameters is a total procedure time, wherein a current magnitude for said total procedure time is assumed, and wherein said performing a first deriving step further comprises performing a first iteration procedure, said performing a first iteration procedure step comprising calculating a current blood component yield using the lesser of said calculated and theoretical magnitudes of said inlet flow, the assumed current magnitude for said total procedure time, and said maximum anticoagulant infusion rate, comparing said current blood component yield with said desired blood component yield, and repeating said first iteration procedure using adjusted current total procedure times until said current blood component yield is within a predetermined amount of said desired blood component yield.

13. The method as claimed in claim 11, wherein:

another of said one or more control parameters is a total procedure time and said performing a first deriving step further comprises assuming a current magnitude for said total procedure time and performing a first iteration procedure, said performing a first iteration procedure step comprising calculating a current yield from the lesser of said calculated and theoretical magnitudes of said inlet flow, said anticoagulant ratio, and said maximum anticoagulant infusion rate, and said current magnitude of said total procedure time, comparing said current yield with said desired yield, incrementally adjusting said current magnitude of said total procedure time when said current yield differs from said desired yield by more than a predetermined amount, and repeating said first iteration procedure step until at least one of a first condition and a second condition is satisfied, said first condition being that said current yield is within said first predetermined amount of said desired yield and said second condition being that said first iteration procedure step has been performed a predetermined number of times.

14. A method for collecting at least one predetermined type of blood component from a source of whole blood using a blood component collection system comprising at least a blood component collection device, said method comprising the steps of:

providing biological data relating to said source of whole blood;

identifying a desired yield of said at least one predetermined type of blood component;

associating a magnitude with each of one or more control parameters, said one or more control parameters being used in controlling said blood component collection system;

said associating step comprising performing a first deriving step comprising deriving a magnitude for at least one of said one or more control parameters from said providing and identifying steps;

inputting said magnitude of each of said one or more control parameters into said blood component collection system after said associating step; and

performing a collection procedure on said blood component collection device using said inputting step to collect said desired yield of said at least one predetermined type of blood component from said source of whole blood;

wherein;

said at least one of said one or more control parameters is a total procedure time, said performing a first deriving step comprising maximizing an inlet flow and minimizing said total procedure time.

15. A method for collecting at least one predetermined type of blood component from a source of whole blood using a blood component collection system comprising at least a blood component collection device, said method comprising the steps of:

providing biological data relating to said source of whole blood;

identifying a desired yield of said at least one predetermined type of blood component;

associating a magnitude with each of one or more control parameters, said one or more control parameters being used in controlling said blood component collection system;

said associating step comprising performing a first deriving step comprising deriving a magnitude for at least one of said one or more control parameters from said providing and identifying steps;

inputting said magnitude of each of said one or more control parameters into said blood component collection system after said associating step; and

performing a collection procedure on said blood component collection device using said inputting step to collect said desired yield of said at least one predetermined type of blood component from said source of whole blood;

further comprising the steps of;

providing a magnitude for each of said one or more control parameters before said identifying step;

performing said collection procedure on said blood component collection device before said identifying step, using said inputting said magnitude step for a first time period, wherein said associating step is performed after expiration of said first time period.