Ultrasound enhancement of transdermal transport

• US 6,234,990 B1
• Filed: 06/30/1997
• Issued: 05/22/2001
• Est. Priority Date: 06/28/1996
• Status: Expired due to Fees

• Current Assignee: Sontra Medical, Inc. (Echo Therapeutics Incorporated)
• Original Assignee: Sontra Medical, Inc. (Echo Therapeutics Incorporated)
• Inventors: Davis, Matthew, Rowe, Stephen, Mitragotri, Samir S., Pishko, Michael, Kost, Joseph
• Primary Examiner(s): KENNEDY, SHARON E
• Application Number:
  US08/885,931
• Time in Patent Office: 1,422 Days
• Field of Search: 601/2, 601/17, 607/154, 604/20, 604/22, 604/49, 604/66, 604/289, 604/290
• US Class Current: 604/22
• CPC Class Codes: A61B 5/14514 using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
• CPC Class Codes: A61B 5/150022 for capillary blood or interstitial fluid
• CPC Class Codes: A61B 5/150083 by vibration, e.g. ultrasound
• CPC Class Codes: A61B 5/150099 by negative pressure, other than vacuum extraction into a syringe by pulling on the piston rod or into pre-evacuated tubes
• CPC Class Codes: A61B 5/150137 by vibration enhancing collection by vibration A61B5/150175
• CPC Class Codes: A61B 5/150259 Improved gripping, e.g. with high friction pattern or projections on the housing surface or an ergonometric shape
• CPC Class Codes: A61B 5/150389 Hollow piercing elements, e.g. canulas, needles, for piercing the skin
• CPC Class Codes: A61B 5/150969 Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing
• CPC Class Codes: A61B 5/150984 Microneedles or microblades
• CPC Class Codes: A61B 5/15136 by use of radiation, e.g. laser
• CPC Class Codes: A61M 2037/0007 having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis

Abstract

Methods and devices for application of ultrasound to a small area of skin for enhancing transdermal transport. An ultrasound beam having a first focal diameter is channelled into a beam having a second, smaller diameter without substantial loss of energy. Higher energy ultrasound can be used while causing less pain. Alternatively, ultrasound energy is applied through a vibrating element positioned just contacting, above or extending into the skin. Use of the element facilitates extraction of analyte and may enhance drug delivery. A two step noninvasive method involves application of ultrasound to increase skin permeability and removal of ultrasound followed by transdermal transport that can be further enhanced using a physical enhancer.

Claims

1. A device for application of ultrasound to the skin for enhancing transdermal transport, the device comprising an ultrasound transducer capable of emitting ultrasound at a frequency between 20 kHz and 2 MHz and walls forming a chamber for containing coupling medium,

wherein the chamber is geometrically configured to direct the ultrasound to induce cavitation at the skin, when the chamber abuts the surface of the skin.

2. The device of claim 1, further comprising means for analyte recovery.

3. The device of claim 1, wherein the chamber walls form a truncated cone with a larger opening and a smaller opening and the transducer is located at the larger opening of the chamber.

4. The device of claim 1, wherein the chamber walls form a horn with a larger opening and a smaller opening and the transducer is located at the larger opening of the chamber.

5. The device of claim 1, wherein the ultrasound frequency which can be emitted by the device is between 20 kHz and 200 kHz.

6. The device of claim 1, further comprising means to apply an additional transdermal transport driving force selected from the group consisting of suction, osmotic pressure gradient, concentration gradient, iontophoresis, electroporation, magnetic field and mechanical pressure.

7. The device of claim 1, wherein the chamber walls are geometrically configured to create an abraded area on the skin having a diameter from about 100 μ

m to one cm.

8. The device of claim 1, wherein the transducer forms a part of the chamber walls.

9. The device of claim 1, wherein the chamber walls are made of a material selected from the group consisting of metal, polymer and ceramic.

10. The device of claim 1, wherein the transducer comprises a plurality of transducers.

11. A method of enhancing transdermal transport, comprising the steps:

providing an ultrasound device comprising an ultrasound transducer capable of emitting ultrasound at a frequency between 20 kHz and 2 MHz and walls forming a chamber for containing coupling medium, wherein the chamber is geometrically configured to direct the ultrasound to induce cavitation at the skin, when the chamber abuts the surface of the skin; and

applying the directed ultrasound to an area of skin.

12. The method of claim 11 of effecting transdermal transport, comprising the steps:

applying ultrasound to an area of skin to make the skin more permeable;

removing the ultrasound; and

applying a transdermal transport driving force selected from the group consisting of additional ultrasound, suction, osmotic pressure gradient, concentration gradient, iontophoresis, electroporation, magnetic field and mechanical pressure.

13. The method of claim 12 wherein the device includes a reservoir for collection of analyte, comprising the ultrasound to enhance analyte recovery.

14. The method of claim 12, wherein the ultrasound is applied by providing ultrasound having a frequency from about 20 kHz to 200 kHz.

15. The method of claim 12, wherein application of the directed ultrasound to the skin creates an abraded area on the skin having a diameter from about 100 μ

m to one cm.