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Microparticles which controllably release olfactorily active substances, methods of using same and processes for preparing same

  • US 6,235,274 B1
  • Filed: 12/21/1999
  • Issued: 05/22/2001
  • Est. Priority Date: 12/21/1999
  • Status: Expired due to Term
First Claim
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1. A process for preparing solid particles, which (i) controllably release one or more olfactory sense effecting compositions of matter therefrom into the environment surrounding said particles and (ii) provide a burst release of olfactory sense effecting compositions of matter when contacted with water, comprising the steps of:

  • (a) adsorbing at least one olfactory sense effecting composition of matter onto silica powder by means of fluidized bed plating in order to provide an olfactory sense effecting composition-bearing silica powder composition;

    (b) providing a molten saccharide composition consisting essentially of a mixture of maltose and mannitol;

    (c) providing an extruder having an extruder input zone and an extruder output zone and having a screw speed of 150-400 rpm;

    (d) substantially simultaneously introducing (i) said saccharide composition and (ii) said olfactory sense effecting composition of matter-bearing silica composition into the extruder at the extruder input zone;

    (e) effecting the blending for a residence time of from about 30 up to about 150 seconds at a temperature in the range of from about 80°

    C. up to about 140°

    C. of the saccharide composition with the olfactory sense effecting composition of matter-bearing silica powder composition in the extruder on operation of the extruder whereby an olfactory sense effecting composition-bearing silica-saccharide tow is formed in the extruder and exits from the extruder at the extruder output zone;

    (f) causing the resulting tow to solidify using drum chilling; and

    (g) converting the resulting solidified drum-chilled tow into particles by means of the unit operation of grinding.

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