Microparticles which controllably release olfactorily active substances, methods of using same and processes for preparing same

• US 6,235,274 B1
• Filed: 12/21/1999
• Issued: 05/22/2001
• Est. Priority Date: 12/21/1999
• Status: Expired due to Term

• Current Assignee: International Flavors & Fragrances Incorporated
• Original Assignee: International Flavors & Fragrances Incorporated
• Inventors: Shefer, Adi, Smith, Leslie C., McDermott, Keith J., Shefer, Shmuel David, Lindauer, Jerome I., Lou, Wen Chin, Tan, Chee-Teck, Teffenhart, John M.
• Primary Examiner(s): Dodson, Shelley A.
• Assistant Examiner(s): Lamm, Marina
• Application Number:
  US09/468,135
• Time in Patent Office: 518 Days
• Field of Search: 428/402, 424/401, 424/65, 424/66, 424/67, 424/68, 424/69, 424/489, 424/490, 424/493, 424/499, 512/1, 512/3, 512/4
• US Class Current: 424/65
• CPC Class Codes: A23L 27/72 Encapsulation
• CPC Class Codes: A23L 27/77 Use of inorganic solid carriers, e.g. silica
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/224 Encapsulating agent
• CPC Class Codes: A23V 2250/1628 Silicium
• CPC Class Codes: A23V 2250/616 Maltose
• CPC Class Codes: A23V 2250/6418 Mannitol
• CPC Class Codes: A61K 2800/56 Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
• CPC Class Codes: A61K 8/0229 Sticks
• CPC Class Codes: A61K 8/0283 Matrix particles
• CPC Class Codes: A61Q 11/00 Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• CPC Class Codes: A61Q 13/00 Formulations or additives for perfume preparations essential oils or perfumes per se C11B9/00
• CPC Class Codes: A61Q 15/00 Anti-perspirants or body deodorants deodorisation of air A61L9/00
• CPC Class Codes: Y10T 428/2982 Particulate matter [e.g., sphere, flake, etc.]

Abstract

Described are flavor composition, flavor component, perfume composition and perfume component-containing microparticles which are particulate matrices composed of:

(a) an olfactorily active component (e.g., perfume component);

(b) silica; and

(c) a saccharide composition which is a mixture of mannitol and maltose.

The microparticles are useful in augmenting, enhancing and/or imparting aroma and/or taste (over relatively long periods of time in a controllably releasable manner) to perfume compositions, perfumed articles (e.g., deodorancy and antiperspirant sticks), foodstuffs, chewing gums, beverages and the like. Also described is a process for preparing the above-mentioned microparticles using, in sequence, (1) adsorption of the olfactorily active material onto silica followed by (2) a blending/extrusion step followed by (3) at least one particularization step.

Claims

1. A process for preparing solid particles, which (i) controllably release one or more olfactory sense effecting compositions of matter therefrom into the environment surrounding said particles and (ii) provide a burst release of olfactory sense effecting compositions of matter when contacted with water, comprising the steps of:

(a) adsorbing at least one olfactory sense effecting composition of matter onto silica powder by means of fluidized bed plating in order to provide an olfactory sense effecting composition-bearing silica powder composition;

(b) providing a molten saccharide composition consisting essentially of a mixture of maltose and mannitol;

(c) providing an extruder having an extruder input zone and an extruder output zone and having a screw speed of 150-400 rpm;

(d) substantially simultaneously introducing (i) said saccharide composition and (ii) said olfactory sense effecting composition of matter-bearing silica composition into the extruder at the extruder input zone;

(e) effecting the blending for a residence time of from about 30 up to about 150 seconds at a temperature in the range of from about 80°

C. up to about 140°

C. of the saccharide composition with the olfactory sense effecting composition of matter-bearing silica powder composition in the extruder on operation of the extruder whereby an olfactory sense effecting composition-bearing silica-saccharide tow is formed in the extruder and exits from the extruder at the extruder output zone;

(f) causing the resulting tow to solidify using drum chilling; and

(g) converting the resulting solidified drum-chilled tow into particles by means of the unit operation of grinding.

2. The process of claim 1 wherein the olfactory sense effecting composition of matter is a fragrance composition or a fragrance composition component.

3. The process of claim 2 comprising the additional step of (h) admixing the resulting ground particles with a deodorant composition and then (i) forming a deodorant stick.

4. The process of claim 2 comprising the additional step of admixing the resulting ground particles with an antiperspirant/deodorant composition and molding the resulting composition into an antiperspirant/deodorant composition and molding the resulting composition into an antiperspirant-deodorant stick.

5. The process of claim 1 wherein the unit operation of grinding is cryogenic grinding.

6. The product produced according to the process of claim 1.

7. The product produced according to the process of claim 2.

8. The deodorant stick prepared according to the process of claim 3.

9. The antiperspirant stick prepared according to the process of claim 4.