Analyte assays and devices
First Claim
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1. A binding pair assay device comprising:
- (a) a housing, wherein the housing is capable of being separated into at least two parts comprising a sampler member and a detection member and further capable of being assembled into one part;
(b) a sample collector within the housing for collecting and delivering sample;
(c) a chromatography region comprising chromatography medium with a transit zone and a capture zone wherein the sample collector is connected by the transit zone to the capture zone; and
(d) a reagent delivery system for delivering a liquid reagent upstream of the sample collector, positioned so that the liquid reagent flows through the sample collector and into the chromatography region.
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Abstract
The present invention provides a method and a device that utilizes capillarity-mediated, chromatographic transport, for the qualitative or semi-quantitative analysis of selected analytes in liquid samples. The device utilizes an applicator/collection device for collecting and administering the sample to the flow path such that reagent(s) flow through the applicator/collection device, washing the sample into the reaction pathway. The device farther utilizes an air gap between the initial location of the reagent and the reaction pathway to funnel the reagent efficiently through the sample so as to collect all or substantially all of the sample and make it available for the reaction(s).
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43 Claims
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1. A binding pair assay device comprising:
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(a) a housing, wherein the housing is capable of being separated into at least two parts comprising a sampler member and a detection member and further capable of being assembled into one part;
(b) a sample collector within the housing for collecting and delivering sample;
(c) a chromatography region comprising chromatography medium with a transit zone and a capture zone wherein the sample collector is connected by the transit zone to the capture zone; and
(d) a reagent delivery system for delivering a liquid reagent upstream of the sample collector, positioned so that the liquid reagent flows through the sample collector and into the chromatography region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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Specification