Use of amines to produce drugs for preventing tumor cell proliferation

• US 6,235,791 B1
• Filed: 04/12/1999
• Issued: 05/22/2001
• Est. Priority Date: 07/29/1996
• Status: Expired due to Fees

• Current Assignee: Sanofi-Aventis (Sanofi )
• Original Assignee: Sanofi-Synthelabo Incorporated (Sanofi )
• Inventors: Van Broeck, Didier, Rosenfeld, Jorge, Breliere, Jean Claude, Lebouteiller, Christine, Ferrara, Pascual, Paul, Raymond
• Primary Examiner(s): CHANG, CELIA C
• Application Number:
  US09/230,643
• Time in Patent Office: 771 Days
• Field of Search: 514/212, 514/227.5, 514/239.5, 514/255, 514/317, 514/422, 514/425, 514/461, 514/617, 514/650, 514/654, 540/484, 540/609, 540/610, 540/612, 544/59, 544/106, 544/178, 544/403, 544/578, 546/16, 546/192, 548/465, 548/548, 548/578, 549/102, 564/161, 564/337, 564/342, 564/345
• US Class Current: 514/650
• CPC Class Codes: A61K 31/137 Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
• CPC Class Codes: A61K 31/35 having six-membered rings with one oxygen as the only ring hetero atom
• CPC Class Codes: A61K 31/40 having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
• CPC Class Codes: A61K 31/445 Non condensed piperidines, e.g. piperocaine
• CPC Class Codes: A61K 31/4453 only substituted in position 1, e.g. propipocaine, diperodon
• CPC Class Codes: A61K 31/495 having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazinesA61K31/48 takes precedence ; with three nitrogen atoms A61K31/53
• CPC Class Codes: A61K 31/5375 1,4-Oxazines, e.g. morpholine
• CPC Class Codes: A61K 31/55 having seven-membered rings, e.g. azelastine, pentylenetetrazole
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 35/02 specific for leukemia
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07C 211/29 the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
• CPC Class Codes: C07C 2601/14 The ring being saturated
• CPC Class Codes: C07D 211/14 with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
• CPC Class Codes: C07D 211/52 having an aryl radical as the second substituent in position 4
• CPC Class Codes: C07D 211/70 with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
• CPC Class Codes: C07D 221/20 Spiro-condensed ring systems
• CPC Class Codes: C07D 307/33 in position 2, the oxygen atom being in its keto or unsubstituted enol form

Abstract

The present invention relates to the use of compounds capable of displacing tritiated cis-N-cyclohexyl-N-ethyl [3-(3-chloro-4-cyclohexylphenyl)-allyl]amine from its receptors for the preparation of pharmaceutical compositions intended to combat cell proliferation.

Claims

1. A method of combating tumor or cancer cell proliferation which comprises administering to a patient in need of such treatment an effective amount of cis-N-cyclohexyl-N-ethyl[3-(3-chloro-4-cyclohexylphenyl)allyl]amine or a pharmaceutically acceptable salt or solvate thereof.

2. A method according to claim 1, wherein the cell proliferation is hormone-sensitive.

3. A method according to claim 1, wherein the cell proliferation is hormone-insensitive.