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Methods of synthesis and use

  • US 6,235,886 B1
  • Filed: 03/09/1995
  • Issued: 05/22/2001
  • Est. Priority Date: 09/03/1993
  • Status: Expired due to Fees
First Claim
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1. A compound having the structure:

  • wherein;

    B is a purine or pyrimidine heterocyclic base;

    R8 and R9 are, independently, H, PO2

    , a nucleotide, an oligonucleotide or an amine-containing species, and at least one of R8 and R9 is a purine containing oligonucleotide; and

    at least one of R9 and A is a species comprising the formula L1-L2-polyamine wherein L1 is an amino linker comprising an amino group, and L2 is a heterobifunctional linker;

    provided that;

    if R8 is not a purine containing oligonucleotide then;

    R8 is a nucleotide or PO2

    ;

    or R9 is H or a nucleotide; and

    if A is not L1-L2-polyamine, then A is H or OH.

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