Methods and apparatus for predicting contrast agent uptake in a computed tomography system

• US 6,236,706 B1
• Filed: 12/12/1996
• Issued: 05/22/2001
• Est. Priority Date: 12/12/1996
• Status: Expired due to Term

• Current Assignee: General Electric Company
• Original Assignee: General Electric Company
• Inventors: Hsieh, Jiang
• Primary Examiner(s): BRUCE, DAVID VERNON
• Application Number:
  US09/521,292
• Time in Patent Office: 1,622 Days
• Field of Search: 378/4, 378/8, 378/15, 378/18, 378/98.12, 378/901
• US Class Current: 378/8
• CPC Class Codes: A61B 6/027 characterised by the use of a particular data acquisition trajectory, e.g. helical or spiral
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/481 involving the use of contrast agents
• CPC Class Codes: A61B 6/504 for diagnosis of blood vessels, e.g. by angiography
• CPC Class Codes: Y10S 378/901 Computer tomography program or processor

Abstract

The present invention, in one form, is a system which predicts contrast agent uptake in an organ of interest. In accordance with one embodiment, and after the contrast agent has been administered to a patient, a prep scan is performed to determine a base contrast agent uptake measurement. A predictive algorithm is then applied to the base measurement to predict a subsequent contrast agent uptake measurement. The predicted subsequent measurement is then compared to a scanning parameter. Particularly, if the predicted subsequent measurement satisfies the scanning parameter, then an image scan is initiated. If the predicted subsequent measurement does not satisfy the scanning parameter, however, then an additional prep scan is performed to determine a new base contrast agent uptake measurement. The predictive algorithm is then applied to the new base measurement to predict a subsequent contrast agent uptake measurement. The prep scans and predictions are repeated until the predicted subsequent contrast agent uptake measurement satisfies the scanning parameter.

Claims

1. A method for performing a tomographic scan of an object of interest injected with a contrast agent, said method comprising the steps of:

(a) performing a prep scan of the object to determine at least one base contrast agent uptake measurement; and

(b) predicting at least one subsequent contrast agent uptake measurement using a predictive algorithm and the determined base contrast uptake measurement.

2. A method in accordance with claim 1 further comprising the step of performing an image scan if at least one of the predicted subsequent contrast agent uptake measurement satisfies a scanning parameter.

3. A method in accordance with claim 1 further comprising the step of repeating steps (a) and (b) if the predicted subsequent contrast agent uptake measurement does not satisfy a scanning parameter.

4. A method in accordance with claim 1 wherein if at least one of the predicted subsequent contrast agent uptake measurements does not satisfy a scanning parameter, said method further comprises the steps of:

(c) performing an additional prep scan of the object to determine at least one additional base contrast agent uptake measurement; and

(d) predicting at least one subsequent contrast agent uptake measurement using the predictive algorithm and at least one of the determined base contrast uptake measurements.

5. A method in accordance with claim 4 wherein predicting at least one subsequent contrast agent uptake measurement using the predictive algorithm and at least one of the determined base contrast uptake measurements comprises the step of applying the predictive algorithm to each of the determined base contrast uptake measurements.

6. A method in accordance with claim 4 further comprising the step of performing an image scan if at least one of the predicted subsequent contrast agent uptake measurement satisfies a scanning parameter.

7. A method in accordance with claim 4 further comprising the step of repeating steps (c) and (d) if the predicted subsequent contrast agent uptake measurement does not satisfy a scanning parameter.

8. A system for performing a tomographic scan of an object of interest injected with a contrast agent, said system configured to:

(a) perform a prep scan of the object to determine at least one base contrast agent uptake measurement; and

(b) predict at least one subsequent contrast agent uptake measurement using a predictive algorithm and the determined base contrast uptake measurement.

9. A system in accordance with claim 8 further configured to perform an image scan if at least one of the predicted subsequent contrast agent uptake measurement satisfies a scanning parameter.

10. A system in accordance with claim 9 further configured to repeat steps (a) and (b) if at least one of the predicted subsequent contrast agent uptake measurement does not satisfy a scanning parameter.

11. A system in accordance with claim 8 wherein if at least one of the predicted subsequent contrast agent uptake measurements does not satisfy a scanning parameter, said system is further configured to:

(c) perform an additional prep scan of the object to determine at least one additional base contrast agent uptake measurement; and

(d) predict at least one subsequent contrast agent uptake measurement using a predictive algorithm and at least one of the determined base contrast uptake measurements.

12. A system in accordance with claim 11 wherein to predict at least one subsequent contrast agent uptake measurement using a predictive algorithm and at least one of the determined base contrast uptake measurements, said system is further configured to apply the predictive algorithm to each of the determined base contrast uptake measurements.

13. A system in accordance with claim 11 further configured to perform an image scan if the predicted subsequent contrast agent uptake measurement satisfies a scanning parameter.

14. A system in accordance with claim 11 further configured to repeat steps (c) and (d) if the predicted subsequent contrast agent uptake measurement does not satisfy a scanning parameter.

15. A system for producing a tomographic image of an object from scan data of the object, said system comprising an x-ray source and a detector, said object injected with a contrast agent, and said system configured to:

(a) perform a prep scan of the object to determine at least one base contrast agent uptake measurement; and

(b) predict at least one subsequent contrast agent uptake measurement using a predictive algorithm and the determined base contrast uptake measurement.

16. A system in accordance with claim 15 further configured to perform an image scan if the predicted subsequent contrast agent uptake measurement satisfies a scanning threshold.