Method for producing a tomographic image of the body and electric impedance tomograph

• US 6,236,886 B1
• Filed: 01/14/1999
• Issued: 05/22/2001
• Est. Priority Date: 12/11/1996
• Status: Expired due to Fees

• Current Assignee: TCI CO., LTD
• Original Assignee: Technology Commercialization Corporation
• Inventors: Cherepenin, Vladimir Alexeevich, Korjenevsky, Alexandr Vladimirovich, Kultiasov, Yury Sergeevich
• Primary Examiner(s): Lateef, Marvin M.
• Assistant Examiner(s): Lin, Jeoyuh
• Application Number:
  US09/101,139
• Time in Patent Office: 859 Days
• Field of Search: 600/547, 600/481, 600/508, 600/506, 600/373, 600/374, 600/384, 600/483, 128/734, 364/413.13
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0536 Impedance imaging, e.g. by tomography
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61B 5/418 lymph vessels, ducts or nodes

Abstract

The invention is a method of obtaining tomographic images of the human body and the electrical impedance tomograph, in which a source of electric current is used to send electric current at levels undetectable by a human being to pairs of electrodes, between which at least two electrodes are placed. An algorithm of image reconstruction makes it possible to obtain the distribution of absolute conductivity of a body, characterizing the state of soft and bone tissues and blood vessels. The method is fast. It allows one to visualize the changes of conductivity during one cardiocycle and to observe blood filling the heart and vessels. It allows one to obtain time dependence of conductivity of internal areas of the heart, which is an impedance cardiogram, containing additional information about heart function. The use of visualization of conductivity of tissues allows one to observe the processes of internal hemorrhages, to reveal inflammations, to carry out studies of organs of digestion, to observe the state of various tumors, to carry out diagnosis of diseases of the mammary gland, to diagnose various lung diseases. The method allows one to monitor the variation of temperature of internal organs, raising the possibility of diagnosing diseases at early stages. The tomograph is a rather simple, compact device, convenient in operation, safe for a patient and attendants, operating with a standard personal computer. This device can be widely used in medical practice and clinical investigations.

Claims

1. A method for the construction of images of a body using electrical impedance tomography, comprising:

a) placing a series of contact electrodes at spaced intervals on the surface of a body;

b) selecting a pair of electrodes for a set of potential difference measurements, each measurement made by connecting an electric current source to pairs of non-selected electrodes sequentially, said pairs of electrically connected electrodes being separated by at least two other electrodes;

c) selecting different pairs of measurement electrodes and repeating step b) for each pair until all pairs of measurement electrodes had been selected;

d) determining the reference values of the potential differences $u_r^i<br><br>\left(j\right)$

by the approximation of the measured distribution of the potential differences $u_m^i<br><br>\left(j\right)$

in accordance with the expression $u_r^i<br><br>\left(j\right)=c_1^i<br><br>f_1^i<br><br>\left(j\right)+c_2^i<br><br>f_2^i<br><br>\left(j\right)+c_3^i$

while the electric current source is connected to the i^th pair of electrodes, and where i is the number of the exciting pair of electrodes, j is the number of the measuring pair of electrodes, $f_1^i<br><br>\left(j\right)$

is the given distribution of voltage between adjacent electrodes along the boundary of the reference object, $f_2^i<br><br>\left(j\right)$

are signals caused by spurious couplings, and $c_{\mathrm{\alpha <br><br>}}^i<br><br>\left(\mathrm{\alpha <br><br>}=1,2,3\right)$

are the approximating coefficients of the measured distribution of the potential differences; and

e) reconstructing the image of the spatial distribution of conductivity of said body by back projection along equipotential lines according to the expressions;

$S=\sum <br><br>\frac{W^{\mathrm{lt}}<br><br>W^{\mathrm{rt}}}{W^{\mathrm{lt}}+W^{\mathrm{rt}}}<br><br>\left({\mathrm{\lambda <br><br>}}^{\mathrm{lt}}+{\mathrm{\lambda <br><br>}}^{\mathrm{rt}}\right)$${\mathrm{\lambda <br><br>}}^{\mathrm{lt},\mathrm{rt}}=u_r^{\mathrm{lt},\mathrm{rt}}/u_m^{\mathrm{lt},\mathrm{rt}}-1$

where W^lt, W^rt are weighting factors determined according to the procedure of back projection in the direction from the left and from the right intersection of the equipotential line with the surface of said body, S is summed over all positions of the injecting electrodes, $u_m^{\mathrm{lt},\mathrm{rt}}$

are voltages measured on the left and on the right ends of the equipotential line that passes through the given point of the reconstructed cross section, and $u_r^{\mathrm{lt},\mathrm{rt}}$

are the reference potential differences corresponding to a body with homogeneous conductivity or determined according to claim 1d.

2. The method of claim 1, wherein said electric current source is connected to a pair of diametrically opposite electrodes.

3. The method of claim 1, wherein said electric current source is produced by a pulsed voltage in the form of two periods of meander, shifted by 180 degrees in phase with a controlled amplitude that is established by an 8-bit code.

4. The method of claim 1, wherein the signals caused by spurious couplings are determined by measurement.

5. The method of claim 1, wherein a series of electrical impedance tomographs are produced sequentially in time of a body in which the conductivity varies in time and a spectral Fourier transformation of the time dependencies is obtained, thereby permitting the reconstruction of the images of spatial distribution of conductivity of the body for each frequency component.

6. The method of claim 1, wherein the reconstruction of the image of the spatial distribution of absolute conductivity of a body is carried out by normalizing the obtained conductivity values on the basis that the least value of conductivity corresponds to the conductivity of bone tissues and the greatest value of conductivity corresponds to the conductivity of blood.

7. An electrical impedance tomograph device, comprising:

a. a plurality of contact electrodes positioned adjacent to the surface of a body at spaced intervals;

b. current source means to inject current into a pair of excited electrodes separated by at least two other electrodes;

c. means to measure potential differences in other electrodes pairs induced by said pair of excited electrodes such that measurements can be made on a given pair of electrodes while said current source is connected sequentially to each pair of the remaining electrodes and this measurement procedure is repeated on each of the remaining electrode pairs;

d. circuit means to compensate for the contact potential differences on each electrode;

e. computer means to determine the reference values of the potential differences $u_r^i<br><br>\left(j\right)$

by the approximation of the measured distribution of the potential differences $u_m^i<br><br>\left(j\right)$

in accordance with the expression $u_r^i<br><br>\left(j\right)=c_1^i<br><br>f_1^i<br><br>\left(j\right)+c_2^i<br><br>f_2^i<br><br>\left(j\right)+c_3^i$

while the electric current source is connected to the i^th pair of electrodes, and where i is the number of the exciting pair of electrodes, j is the number of the measuring pair of electrodes, $f_1^i<br><br>\left(j\right)$

is the given distribution of voltage between adjacent electrodes along the boundary of the reference object, $f_2^i<br><br>\left(j\right)$

are signals caused by spurious couplings, and $c_{\mathrm{\alpha <br><br>}}^i<br><br>\text{\hspace{1em}<br><br>}<br><br>\left(\mathrm{\alpha <br><br>}=1,2,3\right)$

are the approximating coefficients of the measured distribution of the potential differences; and

;

f. computer means to reconstruct the image of the spatial distribution of conductivity of said body by back projection along equipotential lines according to the expressions;

$S=\sum <br><br>\frac{W^{\mathrm{lt}}<br><br>W^{\mathrm{rt}}}{W^{\mathrm{lt}}+W^{\mathrm{rt}}}<br><br>\left({\mathrm{\lambda <br><br>}}^{\mathrm{lt}}+{\mathrm{\lambda <br><br>}}^{\mathrm{rt}}\right)$${\mathrm{\lambda <br><br>}}^{\mathrm{lt},\mathrm{rt}}=u_r^{\mathrm{lt},\mathrm{rt}}/u_m^{\mathrm{lt},\mathrm{rt}}-1$

where W^lt, W^rt are weighting factors determined according to the procedure of back projection in the direction from the left and from the right intersection of the equipotential line with the surface of said body, S is summed over all positions of the injecting electrodes, $u_m^{\mathrm{lt},\mathrm{rt}}$

are voltages measured on the left and on the right ends of the equipotential line that passes through the given point of the reconstructed cross section, and $u_r^{\mathrm{lt},\mathrm{rt}}$

are the reference potential differences corresponding to a body with homogeneous conductivity.

8. The device of claim 7, wherein said current source means is connected to a pair of diametrically opposite electrodes.

9. The device of claim 7, wherein said current source means is produced by a pulsed voltage in the form of two periods of meander, shifted by 180 degrees in phase with a controlled amplitude that is established by an 8-bit code.

10. The device of claim 7, further including a comparator means by which voltages measured at other electrodes that fall outside an allowable range are flagged for attention.