Drug-device combination for controlling the contractility of muscles

• US 6,236,887 B1
• Filed: 03/12/1999
• Issued: 05/22/2001
• Est. Priority Date: 09/17/1996
• Status: Expired due to Term

• Current Assignee: Impulse Dynamics NV
• Original Assignee: Impulse Dynamics NV
• Inventors: Ben-Haim, Shlomo, Darvish, Nissim, Mika, Yuval, Fenster, Maier
• Primary Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US09/254,993
• Time in Patent Office: 802 Days
• Field of Search: 607/9, 607/11, 607/68, 607/3, 607/28
• US Class Current: 607/3
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61B 2017/0243 for immobilizing local areas of the heart, e.g. while it beats trocars attached to inner organs or inner body tissue A61B2017/3488
• CPC Class Codes: A61N 1/32 alternating or intermittent currents applying electric fields by inductive or capacitive coupling A61N1/40; microwave apparatus A61N5/02
• CPC Class Codes: A61N 1/36034 specified by the stimulation parameters
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/3629 in combination with non-electric therapy
• CPC Class Codes: A61N 1/36557 controlled by chemical substances in blood
• CPC Class Codes: A61N 1/36564 controlled by blood pressure
• CPC Class Codes: A61N 1/368 comprising more than one electrode co-operating with different heart regions A61N1/3622, A61N1/3627 take precedence

Abstract

An apparatus for the combined drug/electric-stimulation treatment of a cardiac muscle comprises circuitry (S) for creating a non-excitatory electric potential between at least two points (R1, R2) located in the vicinity of a muscle (H). A method for the combined drug/electric-stimulation treatment of a cardiac muscle, using the apparatus, involves controlling the start time, duration, and magnitude of the electric current flowing between said at least two points, to impart a desired change in cardiac muscle performance.

Claims

1. A method for the combined drug/electric stimulation treatment of a cardiac muscle, comprising a) administering to a patient in need thereof a drug which affects the cardiovascular system and which affects the cardiac muscle, or a mixture of two or more such drugs, b) creating a non-excitatory electric potential between at least two points located in the vicinity of the muscle, and c) controlling one or more of the parameters consisting of start time, duration, magnitude and polarity of the non-excitatory electric potential created between said at least two points.

9. A method according to any one of claims 1, 2, and 8, wherein the change in cardiac muscle contractility is designed at least partially to compensate for cardiac muscle contractility decrease induced by said drug or mixture of drugs.

10. A method according to any one of claims 1, 2, and 8, wherein the change in cardiac muscle contractility is designed at least partially to compensate for cardiac muscle contractility increase induced by said drug or mixture of drugs.

11. A method according to any one of claims 1, 2, and 8, wherein the change in cardiac muscle contractility is designed to add to and/or amplify the cardiac muscle contractility increase or decrease induced by said drug or mixture of drugs.

12. A method according to any one of claims 1, 2, and 8, for reducing the dosage of a cardiovascular drug which affects cardiac muscle contractility.

13. A method according to any one of claims 1, 2, and 8, for reducing the dosage of a cardiovascular drug which affects the electrophysiological characteristics of the cardiac muscle.

2. A method for the combined drug/electric stimulation treatment of a cardiac muscle, comprising a) administering to a patient in need thereof a drug which affects the cardiovascular Stem and which affects the cardiac muscle, or a mixture of two or more such drugs, b) causing a non-excitatory electric current to flow between at least two points located in the vicinity of the muscle, and c) controlling one or more of the parameters consisting of start time, duration, magnitude and polarity of the non-excitatory electric current flowing between said at least two points.

3. A method according to claim 2, wherein the non-excitatory electric current is a DC current.

4. A method according to claim 3, further comprising generating a complex signal by superimposing on the DC signal one or more waveforms of given frequency and amplitude.

5. A method according to any one of claims 2 to 4, wherein the flow of the non-excitatory DC electric current is synchronized to heart activity.

6. A method according to claim 5, wherein the non-excitatory DC electric current flows not at every beat of the heart.

7. A method according to claim 6, wherein the non-excitatory DC electric current flows every 1, 2 or 3 beats of the heart.

8. A method for the combined drug/electric-stimulation treatment of a cardiac muscle, comprising:

administering to a patient in need thereof a drug which affects the cardiovascular system and which affects the cardiac muscle, or a mixture of two or more such drugs;

providing means for creating an electric potential between at least two points located in the vicinity of the cardiac muscle;

providing means for causing a non-excitatory electric current to flow between said at least two point; and

controlling the start time, duration and magnitude of the electric current flowing between said at least two points so as to impart a desired change in cardiac muscle contractility.

14. A method for the combined drug/electric-stimulation treatment of a cardiac muscle, comprising:

administering to a patient in need thereof a drug which affects the cardiovascular system and which affects the cardiac muscle, or a mixture of two or more such drugs;

providing an electric potential between at least a pair of electrodes in the vicinity of the cardiac muscle at at least two root locations;

causing a non-excitatory electric current to flow between said at least two contacting locations; and

controlling the start time, duration and magnitude of the electric current flowing between said at least two root locations, so as to impart the desired change in cardiac muscle contractility.

15. A method according to claim 14, wherein the means for causing a non-excitatory electric current to flow, are synchronized to heart activity.

16. A method according to claim 15, wherein the means for causing a non-excitatory electric current to flow operate not at every beat of the heart.

17. A method according to claim 16, wherein the means for causing a non-excitatory electric current to flow operate every 1, 2 or 3 beats of the heart.

18. Apparatus for the combined drug/electric-stimulation treatment of a cardiac muscle, comprising:

means for creating an electric potential between at least two points located in the vicinity of the cardiac muscle;

means for causing a non-excitatory electric current to flow between said at least two points;

means for controlling the start time, duration and magnitude of the electric current flowing between said at least two points; and

means for superimposing on the DC signal one or more waveforms of given frequency and amplitude, thereby to generate a complex signal.

19. Apparatus according to claim 20, comprising:

means for creating an electric potential between at least a pair of electrodes in the vicinity of the cardiac muscle at at least two root locations;

means for causing a non-excitatory electric current to flow between said at least two root locations;

means for controlling the start time, duration and magnitude of the electric current flowing between said at least two root locations; and

means for superimposing on the DC signal one or more waveforms of given frequency and amplitude, thereby to generate a complex signal.