Anti-microbial coating for medical devices

• US 6,238,686 B1
• Filed: 06/25/1997
• Issued: 05/29/2001
• Est. Priority Date: 05/19/1992
• Status: Expired due to Term

• Current Assignee: NUCRYST Pharmaceuticals Corp. (The Westaim Corporation)
• Original Assignee: Westaim Technologies Inc.
• Inventors: Morris, Larry Roy, Burrell, Robert Edward
• Primary Examiner(s): Azpuru, Carlos A.
• Application Number:
  US08/882,286
• Time in Patent Office: 1,434 Days
• Field of Search: 424/423
• US Class Current: 424/423
• CPC Class Codes: A01N 59/16 Heavy metals; Compounds thereof
• CPC Class Codes: A61B 2018/00119 with metal oxide nitride
• CPC Class Codes: A61L 17/145 Coating
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/306 Other specific inorganic materials not covered by A61L27/303 - A61L27/32
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/106 Inorganic materials other than carbon
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C23C 14/0036 Reactive sputtering
• CPC Class Codes: C23C 14/025 Metallic sublayers
• CPC Class Codes: C23C 14/06 characterised by the coating material C23C14/0021 , C23C14/04 take precedence
• CPC Class Codes: C23C 14/0688 Cermets, e.g. mixtures of metal and one or more of carbides, nitrides, oxides or borides
• CPC Class Codes: C23C 14/086 of zinc, germanium, cadmium, indium, tin, thallium or bismuth
• CPC Class Codes: C23C 14/14 Metallic material, boron or silicon
• CPC Class Codes: C23C 14/16 on metallic substrates or on substrates of boron or silicon
• CPC Class Codes: C23C 14/205 : by cathodic sputtering
• CPC Class Codes: C23C 14/225 : Oblique incidence of vaporised material on substrate
• CPC Class Codes: C23C 14/35 : by application of a magnetic field, e.g. magnetron sputtering C23C14/3457 takes precedence
• CPC Class Codes: C23C 14/588 : by mechanical treatment
• CPC Class Codes: H01H 2300/014 : Application surgical instrument
• CPC Class Codes: Y10S 977/781 : Possessing nonosized surface openings that extend partially into or completely through the host material
• CPC Class Codes: Y10S 977/89 : Deposition of materials, e.g. coating, cvd, or ald
• CPC Class Codes: Y10S 977/891 : Vapor phase deposition
• CPC Class Codes: Y10S 977/904 : for medical, immunological, body treatment, or diagnosis
• CPC Class Codes: Y10S 977/931 : Medical device coating

Abstract

Anti-microbial coatings and method of forming same on medical devices are provided. The coatings are formed by depositing a biocompatible metal by vapour deposition techniques to produce atomic disorder in the coating such that a sustained release of metal ions sufficient to produce an anti-microbial effect is achieved. Preferred deposition conditions to achieve atomic disorder include a lower than normal substrate temperature, and one or more of a higher than normal working gas pressure and lower than normal angle of incidence of coating flux. Anti-microbial powders formed by mechanical working to produce atomic disorder are also provided. The invention extends to other metal coating and powders similarly formed so as to provide enhanced solubility.

Claims

1. A modified material comprising:

one or more metals in a form characterized by sufficient atomic disorder such that the material, in contact with a solvent for the material, releases atoms, ions, molecules or clusters containing at least one metal at an enhanced rate relative to its normal ordered crystalline state.

2. The material as set forth in claim 1 in the form of a powder or foil.

3. The material as set forth in claim 1 in the form of a coating.

4. The material as set forth in claim 2, wherein the material is cold worked to create the atomic disorder.

5. The material as set forth in claim 3, wherein the material is formed by vapour deposition.

6. The material as set forth in claim 5, wherein the material is formed by physical vapour deposition.

7. The materials as set forth in claim 1, 2, or 3, wherein at least one of the metals is an anti-microbial metal and wherein the material is formed with sufficient atomic disorder that the atoms, ions, molecules or clusters of the anti-microbial metal are released at a concentration sufficient to provide a localized anti-microbial effect on a sustainable basis.

8. The material as set forth in claim 1, 4, or 6, wherein the metal is selected from the group consisting of Ag, Au, Pt, Pd, Ir, Sn, Cu, Sb, Bi, and Zn or an alloy or compound thereof.

9. The material as set forth in claim 1, 4, or 6, wherein the metal is Ag, Au or Pd or an alloy or compound of one or more of these metals.

34. The material as set forth in claim 6, wherein the coating is a composite coating formed from at least one first metal, which is the metal to be released, in a matrix containing atoms or molecules of a different material from the first metal, the atoms or molecules of the different material creating atomic disorder in the matrix.

35. The material as set forth in claim 34, wherein the different material is selected from reacted species of the first metal or metal compound;

absorbed or trapped atoms or molecules of oxygen, nitrogen, hydrogen, boron, sulphur and halogen; and

a second metal.

36. The material as set forth in claim 35, wherein the first metal is an anti-microbial metal and the different material is selected from oxides, nitrides, hydrides, halides, borides, and carbides of an anti-microbial or a second metal;

and absorbed or trapped atoms or molecules containing oxygen, nitrogen, hydrogen, boron, sulphur and halogen.

37. The material as set forth in claim 34, wherein the first metal is an anti-microbial metal and the different material is an oxide, nitride, boride, sulphide, halide or hydride of an inert metal selected from Ta, Ti, Nb, V, Hf, Zn, Mo, Si, and Al.

38. The material as set forth in claim 34, comprising silver oxide, silver metal and optionally absorbed or trapped atoms or molecules containing oxygen, nitrogen, hydrogen, boron, sulphur and halogen.

40. The method as set forth in claim 38, wherein the first metal is an anti-microbial metal and wherein the different material is selected from atoms or molecules containing oxygen, nitrogen, hydrogen, boron, sulphur and halogen absorbed or trapped in the matrix from the atmosphere of the vapour deposition.

42. The method as set forth in claim 40, wherein the first metal is an anti-microbial metal and wherein the different material is an oxide, nitride, carbide, boride, halide, sulphide or hydride of an inert metal selected from Ta, Ti, Nb, V, Hf, Zn, Mo, Si and Al.

43. The method as set forth in claim 42, wherein the first metal is silver and the different material is an oxide of Ta, Ti or Nb.

10. A method of forming a modified material containing one or more metals, said method comprising:

creating atomic disorder in the material under conditions which limit diffusion such that sufficient atomic disorder is retained in the material to provide release of atoms, ions, molecules or clusters of at least one of the metals into a solvent for the material at an enhanced rate relative to its normal ordered crystalline state.

11. The method as set forth in claim 10 wherein the material is a powder or foil of one or more of the metals, and wherein the atomic disorder is formed by cold working of the powder or foil.

12. The method as set forth in claim 11, wherein the powder or foil is worked at a temperature below the recrystallization temperature for the powder or foil to retain atomic disorder.

13. The method as set forth in claim 12, wherein the material is a nanocrystalline powder.

14. The method as set forth in claim 12, wherein at least one of the metals is an anti-microbial metal and wherein the material is formed with sufficient atomic disorder that atoms, ions, molecules or clusters of the anti-microbial metal are released at a concentration sufficient to provide a localized anti-microbial effect on a sustainable basis.

15. The method as set forth in claim 12, wherein at least one of the metals is selected from the group consisting of Ag, Au, Pt, Pd, IR, Sn, Cu, Sb, Bi and Zn or alloys or compounds of one or more of these metals.

16. The method as set forth in claim 12, wherein at least one of the metals is Ag, Au or Pd or an alloy or compound containing one or more of these metals.

17. The method as set forth in claim 12, wherein at least one of the metals is silver or an alloy or compound containing silver.

18. The method as set forth in claim 10, wherein the material is formed as a coating on a substrate by vapour deposition under conditions which limit diffusion during deposition and which limit annealing or recrystallization following deposition.

19. The method as set forth in claim 18, wherein the material is formed by physical vapour deposition.

20. The method as set forth in claim 19, wherein the material is a coating of one or more of the metals formed on a substrate by vacuum evaporation, sputtering, magnetron sputtering or ion plating.

21. The method as set forth in claim 20, wherein the deposition is performed under conditions such that the ratio of the temperature of the substrate to the melting point of the metal or metal compound being deposited is maintained at less than about 0.5.

22. The method as set forth in claim 21 wherein the ratio is maintained at less than about 0.3.

23. The method as set forth in claim 21, wherein the deposition is performed such that the angle of incidence of the coating flux on the substrate to be coated is less than about 75°

.

24. The method as set forth in claim 21, wherein the deposition is performed by vacuum deposition at a pressure greater than 0.1 mT, by arc evaporation at a pressure greater than about 100 mT, or by plating at a pressure greater than 200 mT.

25. The method as set forth in claim 21, wherein the deposition is performed by gas scattering evaporation at a working gas pressure of greater than about 20 mT.

26. The method as set forth in claim 21, wherein the deposition is performed by sputtering at a working gas pressure of greater than about 75 mT.

27. The method as set forth in claim 21, wherein the deposition is performed by magnetron sputtering at a working gas pressure of greater than about 10 mT.

28. The method as set forth in claim 21, wherein the deposition is performed by ion plating at a working gas pressure of greater than about 200 mT.

29. The method as set forth in claim 20, wherein at least one of the metals is an anti-microbial metal and wherein the material is formed with sufficient atomic disorder that atoms, ions, molecules or clusters of the anti-microbial metal are released at a concentration sufficient to provide a localized anti-microbial effect on a sustainable basis.

30. The method as set forth in claim 21, 23 or 27, wherein at least one of the metals is an anti-microbial metal and wherein the material is formed with sufficient atomic disorder that atoms, ions, molecules or clusters of the anti-microbial metal are released at a concentration sufficient to provide a localized anti-microbial effect on a sustainable basis.

31. The method as set forth in claim 20, wherein a composite coating is formed by co-, sequentially or reactively depositing a first metal in a matrix with atoms of molecules of a different material from the first metal such that atomic disorder is created in the matrix.

32. The method as set forth in claim 31, wherein the first metal is an anti-microbial metal and wherein the different material is atoms or molecules reactively deposited into the matrix from the working gas atmosphere during deposition.

33. The method as set forth in claim 31, wherein the first metal is an anti-microbial metal and wherein the different material is atoms or molecules selected from oxides, nitrides, carbides, borides, sulphides and halides of an inert biocompatible metal.

39. The method as set forth in claim 18, wherein the modified material is a composite coating formed by co-, sequentially or reactively depositing a first metal in a matrix with atoms or molecules of a different material from the first metal such that atomic disorder is created in the matrix.

41. The method as set forth in claim 39, wherein the first metal is silver and the different material is selected from atoms or molecules containing oxygen, nitrogen, hydrogen, boron, sulphur and halogen.

44. The method as set forth in claim 21, wherein the deposition is performed by magnetron sputtering at a working gas atmosphere of greater than about 30 mT.