High load formulations and methods for providing prolonged local anesthesia
First Claim
1. A formulation for providing pain relief at a site in a patient comprising a local anesthetic in a biocompatible biodegradable controlled release form and a glucocorticosteroid in an amount effective to prolong the effect of the local anesthetic such that the duration of effect is greater than that obtained by use of the same dose of local anesthetic in controlled release form in the absence of the glucocorticosteroid.
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Accused Products
Abstract
A formulation for inducing sustained local anesthesia in a patient comprising a substrate comprising a high load of local anesthetic by weight and an effective amount of a biocompatible, controlled release material to obtain a. reversible nerve blockade or anesthesia effect when implanted or injected in a patient, and a non-toxic glucocorticosteroid agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the glucocorticosteroid agent.
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Citations
38 Claims
- 1. A formulation for providing pain relief at a site in a patient comprising a local anesthetic in a biocompatible biodegradable controlled release form and a glucocorticosteroid in an amount effective to prolong the effect of the local anesthetic such that the duration of effect is greater than that obtained by use of the same dose of local anesthetic in controlled release form in the absence of the glucocorticosteroid.
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20. A formulation for sustained release of a local anesthetic at a site in a patient comprising a local anesthetic and a glucocorticosteroid incorporated into a biocompatible biodegradable polymer, the formulation including the local anesthetic in a concentration effective to provide pain relief at the site and the glucocorticosteroid in a concentration effective to prolong the effect of the local anesthetic such that the duration of effect is greater than that obtained by use of the same dose of local anesthetic in controlled release form in the absence of the glucocorticosteroid.
- 21. A method for providing pain relief at a site in a patient, comprising administering a local anesthetic in a controlled release form and administering a glucocorticosteroid at the site in an amount effective to substantially prolong the effect of the local anesthetic such that the duration of effect is greater than that obtained by use of the same dose of local anesthetic in controlled release form in the absence of the glucocorticosteroid.
- 33. A formulation for providing prolonged pain relief at a site in a patient comprising a local anesthetic incorporated into a biocompatible, biodegradable controlled release form selected from the group consisting of slabs, beads, pellets, microparticles, microspheres, microcapsules, and pastes, said local anesthetic being contained in said controlled release form at a percent loading ranging from about 60 percent to about 90 percent by weight, said controlled release form further comprising a glucocorticosteroid in an amount effective to prolong the effect of local anesthetic such that the duration of effect is greater than that obtained by use of the same dose of local anesthetic in controlled release form in the absence of the glucocorticosteroid.
Specification