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Oligonucleotides having chiral phosphorus linkages

  • US 6,239,265 B1
  • Filed: 12/09/1998
  • Issued: 05/29/2001
  • Est. Priority Date: 01/11/1990
  • Status: Expired due to Fees
First Claim
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1. An oligonucleotide comprising a plurality of nucleoside units linked together via phosphate linkages, wherein:

  • at least two of the nucleoside units are linked via a chiral phosphate linkage;

    at least one of said chiral phosphate linkages being between the 3′

    -terminal nucleosicle and its adjoining nucleoside; and

    with the proviso that said oligonucleotide has less than all of said nucleoside units linked together by either all Rp or all Sp linkages.

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