Method and apparatus for magnetic resonance imaging of arteries using a magnetic resonance contrast agent

• US 6,240,311 B1
• Filed: 07/29/1998
• Issued: 05/29/2001
• Est. Priority Date: 06/07/1993
• Status: Expired due to Term

• Current Assignee: Martin R. Prince
• Original Assignee: Martin R. Prince
• Inventors: Prince, Martin R.
• Primary Examiner(s): Casler, Brian L.
• Application Number:
  US09/124,263
• Time in Patent Office: 1,035 Days
• Field of Search: 600/420, 600/410, 600/419, 600/431, 324/307, 324/309, 424/9.36, 424/9.3
• US Class Current: 600/420
• CPC Class Codes: A61B 5/201 Assessing renal or kidney functions
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61K 49/18 characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• CPC Class Codes: A61M 5/007 for contrast media
• CPC Class Codes: A61M 5/1456 with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: G01R 33/281 Means for the use of in vitro contrast agents G01R33/282 takes precedence; involving use of a contrast agent in MR imaging G01R33/5601; in vivo contrast agents A61K49/0002
• CPC Class Codes: G01R 33/5601 involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
• CPC Class Codes: G01R 33/5619 by temporal sharing of data, e.g. keyhole, block regional interpolation scheme for k-Space [BRISK]
• CPC Class Codes: G01R 33/563 of moving material, e.g. flow contrast angiography
• CPC Class Codes: G01R 33/56308 Characterization of motion or flow; Dynamic imaging
• CPC Class Codes: G01R 33/5635 Angiography, e.g. contrast-enhanced angiography [CE-MRA] or time-of-flight angiography [TOF-MRA]

Abstract

The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins. The present invention includes a detection system for monitoring and detecting the arrival of the contrast agent in the artery and tissues of interest. When the concentration of contrast agent in the artery of the region of interest is maximum, substantially elevated or elevated (e.g., about 20-50% greater than the response of the region of interest to a series of magnetic resonance pulses before administration of a magnetic resonance contrast agent), a predetermined portion of the magnetic resonance image data (e.g., data which is representative of the center of k-space) may be acquired. Thus, the present invention facilitates synchronization between collecting the central portion of k-space image data with the arterial phase of contrast enhancement. The center of k-space corresponds to the lowest spatial frequency data which dominates image contrast.

Claims

1. An apparatus for imaging an artery of a patient using magnetic resonance imaging and an administered magnetic resonance contrast agent, comprising,

a monitor unit to allow an operator to observe a change in a concentration of the contrast agent in a region of interest;

an operator interface to generate an image acquisition signal; and

imaging means for collecting image data which is representative of at least a portion of a center of k-space in response to the image acquisition signal wherein the operator interface generates the image acquisition signal in response to an input from the operator after the operator observes the change in the concentration of contrast agent in the region of interest.

2. The apparatus of claim 1 wherein the operator interface generates the image acquisition signal in response to an input from the operator after the operator observes an arrival of the contrast agent in the region of interest and wherein the imaging means collects image data which is representative of the center of k-space substantially at a beginning of a 3D imaging sequence.

3. The apparatus of claim 1 wherein the imaging means collects image data which is representative of a central portion of the center of k-space when a concentration of the contrast agent in the artery is substantially higher than a concentration of the contrast agent in veins adjacent to the artery.

4. The apparatus of claim 3 wherein the operator interface generates the image acquisition signal in response to an input from the operator after the operator observes a beginning of the arterial phase of contrast agent enhancement in the region of interest.

5. The apparatus of claim 4 further including an administration means for administering the contrast agent at a rate greater than about 1 cc/sec and wherein the region of interest includes at least a portion of the artery and wherein the artery is the aorta.

6. The apparatus of claim 4 further including an administration means for administering the contrast agent at a rate greater than about 0.05 millimoles/sec and wherein the region of interest includes at least a portion of the artery and wherein the artery is the aorta.

7. The apparatus of claim 1 wherein the imaging means collects a first image data set including image data which is representative of at least a portion of a center of k-space before administering a magnetic resonance contrast agent and collects a second image data set including image data which is representative of at least a portion of a center of k-space in response to the image acquisition signal.

8. The apparatus of claim 7 wherein the imaging means constructs an image of the artery by subtracting at least two images selected from a set of images comprising images of the first image data set and images of the second image data set.

9. An apparatus for imaging an artery of a patient using magnetic resonance imaging and an administered magnetic resonance imaging contrast agent, comprising,

a monitoring unit to allow an operator to monitor a region of interest and observe the administered magnetic resonance contrast agent arriving in the region of interest;

an image acquisition signal generator for generating an image acquisition signal;

imaging means for collecting image data, in response to the image acquisition signal, which is representative of a substantial portion of a center of k-space; and

wherein the monitoring unit allows the operator to synchronize the collection of the image data which is representative of a substantial portion of a center of k-space with a concentration of contrast agent in the artery which is substantially a greater than a concentration of contrast agent in veins adjacent the artery.

10. The apparatus of claim 9 wherein the imaging means collects the image data which is representative of the center of k-space substantially at a beginning of a 3D imaging sequence.

11. The apparatus of claim 10 wherein the imaging means collects image data which is representative of a periphery of k-space after collecting image data which is representative of the center of k-space.

12. The apparatus of claim 9 further including an operator interface for generating an image acquisition signal in response to an input from the operator wherein the operator initiates collection of the image data after observing the arrival of the contrast agent in the region of interest.

13. The apparatus of claim 12 wherein the imaging means collects the image data which is representative of the center of k-space substantially at a beginning of a 3D imaging sequence.

14. The apparatus of claim 13 wherein the imaging means collects image data which is representative of a periphery of k-space after collecting image data which is representative of the center of k-space.

15. The apparatus of claim 12 wherein the imaging means collects a first image data set including image data which is representative of at least a portion of a center of k-space before administering a magnetic resonance contrast agent and collects a second image data set including image data which is representative of at least a portion of a center of k-space in response to the image acquisition signal.

16. The apparatus of claim 15 wherein the imaging means constructs an image of the artery by subtracting at least two images selected from a set of images comprising images of the first image data set and images of the second image data set.

17. A method of imaging an artery of a patient using magnetic resonance imaging and an administered magnetic resonance contrast agent, comprising,

monitoring a region of interest to observe a change in a concentration of the contrast agent in a region of interest;

generating an image acquisition signal; and

imaging at least a portion of the artery in response to the image acquisition signal, including collecting image data which is representative of the center of k-space while a concentration of contrast agent in the artery is substantially greater than a concentration of contrast agent in veins adjacent to the artery.

18. The method of claim 17 further including administering the magnetic resonance contrast agent to the patient in a bolus type injection and wherein imaging at least a portion of the artery includes collecting image data of a 3D imaging sequence and collecting image data which is representative of the center of k-space includes collecting the image data substantially at a beginning of the 3D imaging sequence.

19. The method of claim 17 wherein generating an image acquisition signal further includes generating the image acquisition signal after observing an arrival of the contrast agent in the region of interest.

20. The method of claim 19 wherein collecting image data which is representative of the center of k-space includes collecting the image data which is representative of the center of k-space substantially at a beginning of the 3D imaging sequence.

21. The method of claim 19 wherein collecting image data further includes collecting a first image data set including image data before administering a magnetic resonance contrast agent and collecting a second image data set including image data which is representative of the center of k-space in response to the image acquisition signal.

22. The method of claim 21 further including constructing an image of the artery by subtracting at least two images selected from a set of images comprising images of the first image data set and images of the second image data set.

23. The method of claim 17 wherein generating an image acquisition signal further includes generating the image acquisition signal in response to observing a beginning of the arterial phase of contrast enhancement in the region of interest.

24. The method of claim 23 wherein collecting image data further includes collecting a first image data set including image data before administering a magnetic resonance contrast agent and collecting a second image data set including image data which is representative of the center of k-space in response to the image acquisition signal.

25. The method of claim 24 further including constructing an image of the artery by subtracting at least two images selected from a set of images comprising images of the first image data set and images of the second image data set.