Coated superelastic stent

• US 6,241,691 B1
• Filed: 01/08/1999
• Issued: 06/05/2001
• Est. Priority Date: 12/05/1997
• Status: Expired due to Term

• Current Assignee: Micrus Corporation (Johnson & Johnson)
• Original Assignee: Micrus Corporation (Johnson & Johnson)
• Inventors: Wilson, Peter, Ferrera, David A.
• Primary Examiner(s): O'Connor, Cary
• Assistant Examiner(s): MARMOR II, CHARLES ALAN
• Application Number:
  US09/227,982
• Time in Patent Office: 879 Days
• Field of Search: 600/585, 600/434, 600/435, 604/104, 606/191, 606/194, 606/108, 623/1, 623/11, 623/12, 623/1.1, 623/1.12, 623/1.13, 623/1.15, 623/1.18, 623/1.22, 623/1.34, 623/1.42, 623/1.45, 623/1.47
• US Class Current: 600/585
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12113 within an aneurysm
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/1215 comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
• CPC Class Codes: A61B 2017/12072 the heat created by laser light
• CPC Class Codes: A61B 90/39 Markers, e.g. radio-opaque or breast lesions markers
• CPC Class Codes: A61L 2400/16 Materials with shape-memory or superelastic properties
• CPC Class Codes: A61L 31/044 Collagen
• CPC Class Codes: A61L 31/128 containing other specific inorganic fillers not covered by A61L31/126 or A61L31/127
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/18 Materials at least partially X-ray or laser opaque
• CPC Class Codes: A61M 2025/09191 made of twisted wires

Abstract

The coated superelastic stent is formed from a tube of collagen having an inner structure of a micro-cable made of strands of a material exhibiting superelasticity or shape memory properties, such as nickel-titanium, and includes a strand of radiopaque material, such as platinum or gold, in order to provide a radiopaque marker during interventional therapeutic treatment or vascular surgery. The collagen tube can be loaded with a therapeutic agent for treatment of the desired site in the vasculature.

Claims

1. A superelastic collagen coated stent for use in interventional therapy and vascular surgery, comprising in combination:

a collagen tube; and

a multi-stranded micro-cable disposed within said collagen tube, said multi-stranded micro-cable being formed from a plurality of flexible strands of a resilient shape memory material, said micro-cable including at least one radiopaque strand to provide a radiopaque marker.

2. The superelastic collagen coated stent of claim 1, wherein said combination of a collagen tube and a multi-stranded micro-cable forms a ribbon forming the structure of said stent.

3. The superelastic collagen coated stent of claim 2, wherein said ribbon is configured to have a helical shape.

4. The superelastic collagen coated stent of claim 1, wherein said a multi-stranded micro-cable has a sinusoidal shape.

5. The superelastic collagen coated stent of claim 1, comprising a plurality of said multi-stranded micro-cables disposed within said collagen tube.

6. The superelastic collagen coated stent of claim 1, wherein said at least one radiopaque strand comprises an axially disposed radiopaque wire.

7. The superelastic collagen coated stent of claim 1 wherein said plurality of flexible strands of a resilient material are comprised of a super-elastic material.

8. The superelastic collagen coated stent of claim 7 wherein said super-elastic material comprises a nickel titanium alloy.

9. The superelastic collagen coated stent of claim 1 wherein said shape memory material further comprises a nickel-titanium alloy.

10. The superelastic collagen coated stent of claim 1 wherein said shape memory material further comprises a shape memory polymer.

11. The superelastic collagen coated stent of claim 1 wherein said plurality of flexible strands further comprises a plurality of flexible strands twisted about a central core wire, at least one of said twisted strands comprising a radiopaque strand.

12. The superelastic collagen coated stent of claim 1 wherein said plurality of flexible strands further comprises a plurality of flexible strands twisted about a central core wire, said central core wire being made of a radiopaque material.

13. The superelastic collagen coated stent of claim 1 wherein said radiopaque strand comprises a platinum strand.

14. The superelastic collagen coated stent of claim 1 wherein said radiopaque strand comprises a gold strand.

15. The superelastic collagen coated stent of claim 1 wherein said radiopaque strand comprises a tungsten strand.

16. The superelastic collagen coated stent of claim 1 wherein said at least one radiopaque strand comprise a plurality of strands of said micro-cable, at least one of said plurality of radiopaque strands arrayed in the outer twisted strands of said cable.

17. The superelastic collagen coated stent of claim 1, wherein said collagen tube is loaded with a therapeutic agent.

18. A superelastic collagen coated stent for use in interventional therapy and vascular surgery, comprising in combination:

a multi-stranded micro-cable, said multi-stranded micro-cable being formed from a plurality of flexible strands of a resilient material, said micro-cable including at least one radiopaque strand to provide a radiopaque marker;

a sheath to constrain said strands of said micro-cable about a longitudinal axis; and

said multi-stranded micro-cable and sheath being disposed within a collagen tube.

19. The superelastic collagen coated stent of claim 18 wherein at least one of said strands comprises a shape memory material.

20. The superelastic collagen coated stent of claim 19 wherein said shape memory material comprises a nickel titanium alloy.

21. The superelastic collagen coated stent of claim 18 wherein at least one of said strands comprises a super-elastic material.

22. The superelastic collagen coated stent of claim 21 wherein said superelastic material comprises a nickel titanium alloy.

23. The superelastic collagen coated stent of claim 18 wherein said sheath comprises a containment strand wound about said longitudinal strands.

24. The superelastic collagen coated stent of claim 18 further comprising an outer flexible sheath of low friction material.

25. The superelastic collagen coated stent of claim 18 wherein said sheath comprises a heat shrinkable plastic tube.

26. The superelastic collagen coated stent of claim 18 wherein said plurality of flexible strands of a resilient material are comprised of a super-elastic material.

27. The superelastic collagen coated stent of claim 26 wherein said superelastic material comprises a nickel titanium alloy.

28. The superelastic collagen coated stent of claim 18 wherein said plurality of flexible strands of a resilient material are comprised of a shape memory material.

29. The superelastic collagen coated stent of claim 28 wherein said shape memory material further comprises a nickel-titanium alloy.

30. The superelastic collagen coated stent of claim 28 wherein said shape memory material further comprises a shape memory polymer.

31. The superelastic collagen coated stent of claim 18 wherein said radiopaque strand comprises a platinum strand.

32. The superelastic collagen coated stent of claim 18 wherein said radiopaque strand comprises a gold strand.

33. The superelastic collagen coated stent of claim 18 wherein said radiopaque strand comprises a tungsten strand.

34. The superelastic collagen coated stent of claim 18 wherein said at least one radiopaque strand comprise a plurality of strands of said micro-cable.

35. The superelastic collagen coated stent of claim 18, wherein a plurality of flexible strands are twisted about a longitudinal axis, at least one of said twisted strands being of a radiopaque material.