Process and device for the production of liquid, disperse systems
First Claim
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1. A process for the production of a liquid, disperse system, comprising continuously not batchwise extruding a predispersion comprising water and lipids, liposomes or both under a pressure of 7 to 250 MPa sequentially through 1 to 8 filter stages each stage having a pore diameter of from 0.01 to 35 μ
- m wherein at least one filter in a filter stage is a membrane filter.
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Abstract
A continuous process for the production of liquid, disperse systems is described, which is characterized in that a predispersion is extruded under a high pressure of 6.6 to 250 MPa sequentially over 1 to 8 filter stages of decreasing pore size between 0.01 and 35 μm, and up to 20 passages per filtration stage can be used.
Further, a device is described which can be used for implementing the process according to the invention.
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Citations
32 Claims
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1. A process for the production of a liquid, disperse system, comprising continuously not batchwise extruding a predispersion comprising water and lipids, liposomes or both under a pressure of 7 to 250 MPa sequentially through 1 to 8 filter stages each stage having a pore diameter of from 0.01 to 35 μ
- m wherein at least one filter in a filter stage is a membrane filter.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 32)
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17. A device for the production of a liquid, disperse system comprising a storage vessel having a drainpipe leading to a high-pressure pump, said pump providing a working pressure of from 7 to 250 MPa, and said pump being in communication with a filter holder for 1 to 8 filter stages, each with a pore diameter of 0.01 to 35 μ
- m, at least one filter in a filter stage being a membrane filter, such that material from the storage vessel is continuously not batchwise pumped through the filter stage(s), and means by which the product liquid, disperse system can be recirculated to the filter stage(s), removed from the device, or both.
- View Dependent Claims (18, 19, 20)
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31. A process for the production of a liposome suspension wherein the liposomes contain a contrast medium, which comprises continuously, not batchwise extruding a predispersion comprising water and lipids, liposomes or both and the contrast medium under a pressure of 7 to 250 MPA sequentially through 1 to 8 filter stages each stage having a pore diameter of from 0.01 to 35 μ
- m.
Specification