Non-orbiting tomographic imaging system

• US 6,242,743 B1
• Filed: 08/11/1998
• Issued: 06/05/2001
• Est. Priority Date: 08/11/1998
• Status: Expired due to Term

• Current Assignee: Spectrum Dynamics LLC
• Original Assignee: Mosaic Imaging Technology, Inc.
• Inventors: DeVito, Raymond P., Domnanovich, James R., Haines, Edward J.
• Primary Examiner(s): Hannaher, Constantine
• Assistant Examiner(s): Gabor, Otilia
• Application Number:
  US09/132,331
• Time in Patent Office: 1,029 Days
• Field of Search: 250/363.05, 250/363.01, 250/363.07, 250/363.08, 250/363.09
• US Class Current: 250/363.05
• CPC Class Codes: A61B 6/027 characterised by the use of a particular data acquisition trajectory, e.g. helical or spiral
• CPC Class Codes: A61B 6/037 Emission tomography
• CPC Class Codes: A61B 6/502 for diagnosis of breast, i.e. mammography
• CPC Class Codes: A61B 6/541 involving acquisition triggered by a physiological signal
• CPC Class Codes: G01T 1/2985 In depth localisation, e.g. using positron emitters; Tomographic imaging (longitudinal and transverse section imaging; apparatus for radiation diagnosis sequentially in different planes, steroscopic radiation diagnosis); using external radiation sources A61B6/02

Abstract

A tomographic imaging system which images ionizing radiation such as gamma rays or x rays and which: 1) can produce tomographic images without requiring an orbiting motion of the detector(s) or collimator(s) around the object of interest, 2) produces smaller tomographic systems with enhanced system mobility, and 3) is capable of observing the object of interest from sufficiently many directions to allow multiple time-sequenced tomographic images to be produced. The system consists of a plurality of detector modules which are distributed about or around the object of interest and which fully or partially encircle it. The detector modules are positioned close to the object of interest thereby improving spatial resolution and image quality. The plurality of detectors view a portion of the patient or object of interest simultaneously from a plurality of positions. These attributes are achieved by configuring small modular radiation detector with high-resolution collimators in a combination of application-specific acquisition geometries and non-orbital detector module motion sequences composed of tilting, swiveling and translating motions, and combinations of such motions. Various kinds of module geometry and module or collimator motion sequences are possible, and several combinations of such geometry and motion are shown. The geometric configurations may be fixed or variable during the acquisition or between acquisition intervals. Clinical applications of various embodiments of the tomography invention include imaging of the human heart, breast, brain or limbs, or small animals. Methods of using the non-orbiting tomographic imaging system are also included.

Claims

1. An imaging system for acquisition of tomographic emission data from a radiation source, the imaging system comprising:

a plurality of detector modules, module positioning means, and means for acquiring data, wherein

each detector module comprises a radiation detector and a collimator,

the module positioning means providing means for adjusting the position and viewing angle of each detector module so that each detector module has the ability to view the radiation source from a plurality of positions and angular directions and the ability to move independently of other detector modules, and

wherein data comprises radiation emission data and information regarding the position and orientation of each detector module,

wherein during acquisition of tomographic emission data each detector module moves independently, sweeping through said plurality of positions and angular directions so as to optimize data acquisition without orbiting said radiation source.

2. The imaging system of claim 1 wherein the position and orientation of the detector modules can be varied by single axis rotational motions.

3. The imaging system of claim 1 wherein the position and orientation of the detector modules can be varied by means of multi-axis rotational motions.

4. The imaging system of claim 1 wherein the position and orientation of the detector modules can be varied by means of translational motions.

5. The imaging system of claim 1 wherein the position and orientation of the detector modules can be varied by means of a combination of multi-axis rotational motions and translational motions.

6. The imaging system of claim 5 wherein said multi-axis rotational motions and translational motions are oscillatory.

7. The imaging system of claim 5 wherein the module positioning means comprises a mechanism which is attached to the detector module and is driven by an actuating means, wherein the actuating means comprises an electro-mechanical motor.

8. The imaging system of claim 5 wherein the module positioning means comprises a mechanism which is attached to the detector module and is driven by an actuating means, wherein the actuating means comprises a hydro-mechanical motor.

9. The imaging system of claim 5 wherein the module positioning means comprises a mechanism which is attached to the detector module and is driven by an actuating means, wherein the actuating means comprises a pneumatic device.

10. The imaging system of claim 5 wherein the module positioning means comprises a mechanism which is attached to the detector module and is driven by an actuating means, wherein the actuating means comprises a combination of an electro-mechanical motor, hydro-mechanical motor, and pneumatic device.

11. The imaging system of claim 10 where the mechanism is connected to a position measuring and recording means which determines the position and orientation of the detector module.

12. The imaging system of claim 11 where the position measuring and recording means is comprised of a mechanical device.

13. The imaging system of claim 11 where the position measuring and recording means is comprised of an electrical device.

14. The imaging system of claim 11 where the position measuring and recording means is comprised of optical devices.

15. The imaging system of claim 11 where the position measuring and recording means is comprised of an electro-mechanical device.

16. The imaging system of claim 11 where the position measuring and recording means is comprised of an electro-optical device.

17. The imaging system of claim 11 where the position measuring and recording means is comprised of a combination of mechanical, electrical, optical, electro-mechanical, and electro-optical devices.

18. The imaging system of claim 1 where the detector module further comprises a detection surface and a photon event location recording means, said photon event location means providing the determination of the location of the interaction of a photon on the detection surface of the radiation detector.

19. The imaging system of claim 1 where the radiation detector is comprised of a scintillator and photomultiplier tubes.

20. The imaging system of claim 1 where the radiation detector is a solid state detector.

21. The imaging system of claim 20 where the solid state detector is comprised of Cadmium Telluride as a radiation interaction and conversion medium.

22. The imaging system of claim 20 where the solid state detector is comprised of Cadmium Zinc Telluride as a radiation interaction and conversion medium.

23. The imaging system of claim 1 where means are provided which enable the collimator to change position or orientation relative to the radiation detector.

24. The imaging system of claim 1 wherein the positioning means is maintained in space using a mounting means.

25. The imaging system of claim 24 wherein the mounting means is rigid.

26. The imaging system of claim 24 wherein the mounting means is flexible.

27. The imaging system of claim 24 wherein the mounting means enables rearrangment of the plurality of detector modules during use.

28. An imaging system for acquisition of tomographic imaging information from a radiation emission source, the imaging system comprising radiation detection means, positioning means, information management means, and a radiation emission source wherein

said radiation detection means comprises a plurality of detector modules, each of said detector modules comprising a radiation detector, a collimator, and a photon-event locator means,

said positioning means is used to adjust the angular orientation and linear position of each of said detector modules in space, wherein each of said detector modules is capable of movements which are independent of the remaining detector modules, and

said information management means provides repositioning information to the positioning means and further receives information from said positioning means and from said photon event locator means for use in tomographic image reconstruction,

wherein during acquisition of tomographic imaging information from the radiation emission source, each of said detector modules moves independently, oscillating through a plurality of linear positions and angular orientations so as to optimize information sampling without orbiting said radiation source.

29. The imaging system of claim 28 wherein said detector modules lie in a first plane and said radiation emission source lies in said first plane, and said detector modules generally surround said emission source.

30. The imaging system of claim 29 wherein each of said detector modules are provided with a combination of angular and linear oscillations using said positioning means so as to acquire views of the emission source from multiple locations and viewing angles.

31. The imaging system of claim 30 wherein the arrangement of said detector modules is in the form of a closed curve.

32. The imaging system of claim 31 wherein the arrangement of said detector modules is in the form of a circle.

33. The imaging system of claim 28 wherein a plurality of detector modules lie in each of plural parallel planes, said detector modules within a given plane forming a closed curve, said closed curves being generally coaxial to form a tubular structure having an interior portion and an exterior portion, said tubular structure receiving said radiation emission source within the interior portion.

34. The imaging system of claim 33 wherein each of said detector modules is provided with angular oscillations using said positioning means so as to acquire views of the emission source from multiple locations and viewing angles.

35. The imaging system of claim 28 wherein the detector modules lie in a first plane and said radiation emission source does not lie in said first plane, and said detector modules generally surround a normal to the first plane which intersects said radiation emission source.

36. The imaging system of claim 35 wherein each of said detector modules are provided with a combination of angular and linear oscillations using said positioning means so as to acquire views of the emission source from multiple locations and viewing angles.

37. The imaging system of claim 36 wherein the arrangement of said detector modules is in the form of a closed curve.

38. The imaging system of claim 37 wherein the arrangement of said detector modules is in the form of a circle.

39. The imaging system of claim 36 wherein the arrangement of detector modules is in the form of multiple closed curves.

40. The imaging system of claim 39 wherein the multiple closed curves are placed side by side within said first plane.

41. The imaging system of claim 39 wherein the multiple closed curves are placed concentrically so as to share a common axis within said first plane.

42. The imaging system of claim 28 wherein the detector modules lie on a topological manifold and said radiation emission source lies adjacent said topological manifold but does not intersect said topological manifold.

43. The imaging system of claim 42 wherein each of said detector modules are provided with a combination of angular and linear oscillations using said positioning means so as to acquire views of the emission source from multiple locations and viewing angles.

44. The imaging system of claim 43 wherein the topological manifold fully surrounds said radiation emission source.

45. The imaging system of claim 43 wherein the topological manifold partially surrounds said radiation emission source.

46. The imaging system of claim 43 wherein the detector modules are maintain on the topological manifold using a mounting means.

47. The imaging system of claim 46 wherein the mounting means is a harness.

48. The imaging system of claim 47 wherein the harness is rigid.

49. The imaging system of claim 47 wherein the harness is semi-rigid.

50. The imaging system of claim 47 wherein the harness is flexible.

51. An imaging system for acquisition of tomographic emission data from an emission source, the imaging system comprising an imaging device and an emission source, the imaging device comprising a plurality of detector modules, module positioning means, and a means for acquiring data, wherein

each detector module comprises a radiation detector and a collimator,

a plurality of said detector modules and the emission source lie within a single plane and the plurality of detector modules are positioned and oriented such that the emission source is surrounded by and viewed by the plurality of detector modules,

the module positioning means providing means for adjusting the position and orientation of each detector module during said acquisition of tomographic emission data so that the position of each detector module can be varied by a combination of translational and rotational motions such that each detector module has the ability to view the radiation source from a plurality of positions and directions and the ability to move independently of other detector modules without orbiting said radiation source, and

the data comprises radiation emission data and information regarding the position and orientation of each detector module.

52. An imaging system for acquisition of tomographic emission data from an emission source, the imaging system comprising an imaging device and an emission source, the imaging device comprising a plurality of detector modules, module positioning means, and means for acquiring data, wherein

each detector module comprises a radiation detector and a collimator,

the plurality of detector modules lies in a first plane and the emission source does not lie within said first plane, and wherein the plurality of detector modules are positioned and oriented within the first plane such that the emission source is surrounded by and viewed by the plurality of detector modules,

the module positioning means provides a means for independently adjusting the position and orientation of each detector module during said acquisition of tomographic emission data so that the position and orientation of each of the detector modules can be varied by a combination of translational motions within the first plane and by rotational motions about any of three orthogonal axes defined by the first plane and a normal to the first plane such that the detector module has the ability to view the radiation source from a plurality of positions and directions without orbiting said radiation source and the ability to move independently of other detector modules, and

the data comprises radiation emission data and information regarding the position and orientation of each detector module.

53. An imaging system for acquisition of tomographic emission data from an emission source, the imaging system comprising an imaging device and an emission source, the imaging device comprising a plurality of detector modules, module positioning means, and means for acquiring data, wherein

each detector module comprises a radiation detector and a collimator,

the plurality of detector modules lies within a first non planar surface and the emission source lies at a location which does not intersect first non planar surface, wherein the plurality of detector modules are positioned and oriented within the first non planar surface such that the emission source is surrounded by and viewed by the plurality of detector modules,

the module positioning means providing means for adjusting the position and orientation of each detector module during said acquisition of tomographic emission data so that during said acquisition of tomographic emission data each detector module has the ability to view the radiation source from a plurality of positions and directions without orbiting said radiation and the ability to move independently of other detector modules, and so that the position and orientation of each of the detector modules can be independently varied by

a) translational motions within the first non planar surface,

b) by rotational motions about any of three orthogonal axes, the three orthogonal axes intersecting at the location of a detector module and defined by a normal to the first non planar surface and a plane which is tangent to the non planar surface at a point coincident with a detector module, and

c) by a combination of said translational and rotational motions,

wherein the data comprises radiation emission data and information regarding the position and orientation of each detector module.

54. An imaging system to acquire tomographic emission data, the system comprising an imaging device and a radiation emission source, the imaging system comprising a plurality of detector modules, module positioning means, module position sensing means and data acquisition means, wherein

the detector modules comprise a radiation detector and a collimator,

the detector modules are arranged to form a tubular array by providing a plurality of sets of detector modules, each set of detector modules of said plurality of sets arranged to form a planar closed curve, the planar closed curves being stacked to form the tubular array, the tubular array having a longitudinal axis, an interior side, and an exterior side,

the module positioning means being attached to the tubular array on said exterior side, and enabling multiple degrees of rotation and translation of each of the detector modules, wherein during acquisition of tomographic emission data from the radiation emission source, each of said detector modules moves independently through a plurality of translations and rotations so as to achieve optimum data acquisition without orbiting said radiation source,

the radiation detector and collimator being oriented on the detector modules such that they reside on the interior side of the tubular array;

and

the emission source placed within the interior side of the tubular array.

55. A method for using an imaging system for imaging a radiation emitting source located within a human being,

the imaging system comprising an imaging device and a radiation emission source,

the imaging device comprising a plurality of radiation detector modules, module positioning means, and means for acquiring data, wherein

each detector module contains a radiation detector and a collimator,

the module positioning means providing means for adjusting the position and viewing angle of each detector module so that each detector module has the ability to view the radiation source from a plurality of positions and angular directions and the ability to move independently of other detector modules, and

wherein data comprises radiation emission data and information regarding the position and orientation of each detector module,

the method steps comprising,

1 placement of a radiation emitting source within a human being,

2 arrangement of said radiation detector modules about said radiation emitting source such that the geometry of the arrangement is known,

3 adjusting the position and viewing angle of each detector module without orbiting, said radiation emission source while concurrently acquiring data,

4 reconstruction of an image of the radiation emission source using the acquired data.

56. The method of claim 55 wherein placement of a radiation emitting source is comprised of administration of a radioisotope.

57. The method of claim 55 wherein the radiation detector modules partially enclose the radiation emitting source.

58. The method of claim 55 wherein the radiation detector modules fully enclose the radiation emitting source.

59. The method of claim 55 wherein a further method step comprises calibration of said radiation detector modules, wherein calibration comprises utilizing known distributions of a radiation emitting source to generate calibration data sets, which are then used to produce and update corrections for the data.

60. The method of claim 56 wherein a further method step is inserted following step 3 wherein the is arrangement of said radiation detector modules about said radiation emitting source is changed to a second arrangement about said radiation emitting source such that the geometry of the second arrangement is known.

92. The imaging system of claim 55 wherein each of said set of detector modules is arranged to form one or more arc segments on its respective said closed curve.

61. An imaging system for detection and analysis of tomographic emission data from a radiation source, the imaging system comprising

a plurality of individual detector modules, each individual detector module of said plurality of individual detector modules comprising a radiation detector and a collimator,

module mounting means, and

means for acquiring tomographic emission data, wherein data comprises radiation emission data and information regarding the position and orientation of each individual detector module of said plurality of detector modules,

wherein module mounting means comprises means for controlling the translational position and angular orientation of each individual detector module of said plurality of individual detector modules, such that each individual detector module of said plurality of individual detector modules has a translational position and an angular orientation which is independently movable relative to the remaining individual detector modules,

wherein module mounting means further comprises means for supporting the plurality of individual detector modules in space,

wherein during the collection of tomographic emission data from a radiation source said module mounting means does not orbit about said radiation source, and

wherein during the collection of tomographic emission data from a radiation source each individual detector module translates and angulates through a range of localized positions so as to be able to produce a computed tomographical image of the radiation source.

62. The imaging system of claim 61, wherein the position and orientation of each individual detector module of said plurality of individual detector modules can be varied by single axis rotational motions.

63. The imaging system of claim 61 wherein the position and orientation of each individual detector module of said plurality of individual detector modules can be varied by means of multi-axis rotational motions.

64. The imaging system of claim 61 wherein the position and orientation of each individual detector module of said plurality of individual detector modules can be varied by means of rotational motions.

65. The imaging system of claim 61 wherein the position and orientation of each individual detector module of said plurality of individual detector modules can be varied be means of a combination of multi-axis rotational motions and translational motions.

66. The imaging system of claim 65 wherein said multi-axis rotational motions and translational motions are oscillatory.

67. The imaging system of claim 61 wherein the translational and angulations of each of said individual detector modules is related to and synchronized with said collection of tomographic emission data such that said translations and angulations are accomplished in increments of the total required motion, each of said individual detector modules pausing between said increments, and said acquisition of said emission data occurring, during said phase so as to generate a “

point-and-shoot”

pattern of data acquisition.

68. The imaging system of claim 61 wherein the translations and angulations of each of said individual detector modules is related to and synchronized with said collection of tomographic emission data such that said translations and angulations are accomplished in increments of the total required motion, each of said individual detector modules pausing between said increments, and said acquisition of said emission data occurring during said incremental translation and angulation.

69. The imaging system of claim 61 wherein the translations and angulations of each of said individual detector modules is related to and synchronized with said collection of tomographic emission data such that said translations and angulations are accomplished in increments of the total required motion, each of said individual detector modules pausing between said increments, and said acquisition of said emission data occurring both during said incremental translation and angulation and during said pause.

70. The imaging system of claim 61 wherein the translations and angulations of each of said individual detector modules is related to and synchronized with said collection of tomographic emission data such that said translations and angulations are accomplished using oscillations of each of said individual detector modules, said acquisition of said emission data occurring during said oscillatory translations and angulations.

71. The imaging system of claim 61 wherein the module mounting means is rigid.

72. The imaging system of claim 61 wherein the module mounting means is flexible.

73. The imaging system of claim 61 wherein the module mounting means enables rearrangement of the plurality of detector modules during and between data acquisition.

74. A non-orbiting data acquisition and imaging system for the collection and display tomographic emission data from a radiation source,

said radiation source being located in and surrounded by a first reference volume, said reference volume having a first reference frame which is fixed and non-moving,

said non-orbiting data acquisition and imaging system comprising a plurality of individual detector modules, each individual detector module of said plurality of individual detector modules comprising a radiation detector, a collimator, and a module mounting means,

said non-orbiting data acquisition and imaging system comprising further comprising means for acquiring tomographic emission data, wherein tomographic emission data comprises radiation emission data and information regarding the position and orientation of each individual detector module of said plurality of detector modules,

said module mounting means comprising a plurality of second reference frames, each of said second reference frames beings fixed relative to said module mounting means and being movable relative to said first reference frame,

each individual detector module of said plurality of individual detector modules comprising a plurality of third reference frames, one of said plurality of third reference frames being fixed relative each individual detector module such that each individual detector module has an associated third reference frame, each of said plurality of third reference frames being moveable relative to said first reference frame and each of said plurality of second reference frames,

wherein during acquisition of tomographic emission data by said non-orbiting data acquisition and imaging system, each of said plurality of second reference frames is moveable relative to said first reference frame such that the relative locations of each individual detector module of said plurality of detector modules may be moved with respect to other individual detector modules, and said plurality of second reference frames does not orbit said first reference volume,

wherein during acquisition of tomographic emission data by said non-orbiting data acquisition and imaging system, said plurality of third reference frames are not fixed relative to said plurality of second reference frames such that each individual detector module of said plurality of detector modules is capable of independent translations and angulations relative to said mounting means and said plurality of third reference frames do not orbit said first reference volume.

75. The non-orbiting data acquisition and imaging system of claim 74 wherein each of said plurality of third reference frames being provided with six independent degrees of motion such that each individual detector module is capable of three orthogonal rotations and three orthogonal translations.

76. The non-orbiting data acquisition and imaging system of claim 74 wherein said independent translations and angulations of said plurality of third reference frames are oscillatory.

77. An imaging system to acquire tomographic emission data, the system comprising an imaging device and a radiation emission source, the imaging device comprising a plurality of independent detector modules, each independent detector module having module positioning means module position sensing means, and data acquisition means, wherein

each independent detector module comprises a radiation detector and a collimator,

the plurality of independent detector modules are arranged by providing a plurality of sets of detector modules, each set of detector modules of said plurality of sets of detector modules arranged to form a closed curve, each closed curve having a centroid, the centroid of each closed curve being contained in an axial centroid line, the closed curves forming a surface having an interior surface and an exterior surface,

the module positioning means being attached to each closed curve on said exterior surface, and enabling multiple degrees of rotation and translation of each of the detector modules, wherein during acquisition of tomographic emission data from the radiation emission source, each of said detector modules moves independently through a plurality of translations and rotations so as to achieve optimum data acquisition without orbiting said radiation source,

the radiation detector and collimator being oriented on the detector modules such that they reside on the interior surface, and the emission source residing within the interior surface.

78. The imaging system of claim 77 wherein said closed curves are circular in shape.

79. The imaging system of claim 77 wherein said closed curves are non-planar.

80. The imaging system of claim 77 wherein said centroids of said closed curves are coincident.

81. The imaging system of claim 77 wherein said centroids of said closed curves are distributed along said centroid line such that the centroids are spaced apart from each other.

82. The imaging system of claim 77 wherein said centroid line is a straight line.

83. The imaging system of claim 77 wherein said centroid line is a curved (non-straight) line.

84. The imaging system of claim 77 wherein each of said sets of detector modules is arranged to form one or more arc segments on its respective said closed curve.

85. An imaging system to acquire tomographic emission data, the system comprising an imaging device and a radiation emission source, the imaging device comprising a plurality of independent detector modules, each independent detector module having module positioning means, module positioning means, and data acquisition means, wherein

each independent detector module comprises a radiation detector and a collimator,

the plurality of independent detector modules are arranged by providing a plurality of sets of detector modules, each set of detector modules of said plurality of sets of detector modules arranged to form a closed curve, each closed curve having a centroid, the centroid of each closed curve being contained in a centroid surface, the centroid surface having an inferior side and a superior side,

the module positioning means being attached to each independent detector module on said superior side and enabling multiple degrees of rotation and translation of each of the independent detector modules, wherein during acquisition of tomographic emission data from the radiation emission source, each of said independent detector modules moves independently through a plurality of translations and rotations so as to achieve optimum data acquisition without orbiting said radiation source,

the radiation detector and collimator being oriented on the independent detector modules such that they reside on the inferior side of said centroid surface, and

the emission source residing below the inferior side of said centroid surface.

86. The imaging system of claim 85 wherein said closed curves are circular in shape.

87. The imaging system of claim 85 wherein said closed curves are non-planar.

88. The imaging system of claim 85 wherein said centroids of said closed curves are coincident.

89. The imaging system of claim 85 wherein said centroids of said closed curves are distributed within the centroid frame such that the centroids are spaced apart from each other.

90. The imaging system of claim 85 wherein said centroid surface is a planar.

91. The imaging system of claim 85 wherein said centroid surface is non-planar.