Fluid delivery device with temperature controlled energy source

• US 6,245,042 B1
• Filed: 09/03/1999
• Issued: 06/12/2001
• Est. Priority Date: 08/27/1997
• Status: Expired due to Term

• Current Assignee: Pescadero Beach Holdings Corporation
• Original Assignee: Science Incorporated
• Inventors: Thompson, Thomas N., Kriesel, Marshall S.
• Primary Examiner(s): NGUYEN, ANH TUAN TUONG
• Application Number:
  US09/390,219
• Time in Patent Office: 648 Days
• Field of Search: 604/890.1, 604/31, 604/81, 604/113, 604/132, 604/142, 604/145, 604/151, 604/153, 604/185, 604/257, 604/259, 604/95.03, 128/DIG.1, 128/12, 222/94-96
• US Class Current: 604/132
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61K 9/0068 Rumen, e.g. rumen bolus
• CPC Class Codes: A61M 2205/3613 by body heat
• CPC Class Codes: A61M 2250/00 Specially adapted for animals
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/14586 pressurised by means of a flexible diaphragm

Abstract

A delivery device for the administration of nutrients, drugs, vitamins, trace elements and the like to a ruminant. The device embodies a thermal expanding polymer material which, when heated by the animal'"'"'s body heat functions as an internal energy source for controllably expelling the beneficial agents from the device over extended period of time of up to 200 days. The device is of a size and shape that can be introduced into the ruminant via the esophagus and is of a density such that the device will be retained within the reticulo-rumen of the animal for the effective controlled release of the beneficial agents to the animal.

Claims

1. A device for administering beneficial agents to a ruminant at a controlled rate comprising:

(a) a housing;

(b) distendable means for forming, in conjunction with said housing, a reservoir having an inlet and an outlet, said distendable means comprising at least one distendable membrane, at least one portion of which is movable within said housing from a first position to a second position;

(c) heat expandable means disposed within said housing in proximity to said distendable membrane, said heat expandable means comprising a semi-solid, which, upon being heated, will act upon said distendable membrane to move said membrane toward said second position to cause fluid within said reservoir to flow outwardly of said outlet of said reservoir; and

(d) delivery means in communication with said outlet of said reservoir for delivering the beneficial agent from said reservoir to the ruminant.

2. The device as defined in claim 1 in which said heat expandable means comprises a heat expandable gel.

3. The device as defined in claim 1 in which said heat expandable means substantially surrounds said distendable membrane.

4. The device as defined in claim 1 further including a weight disposed within said housing.

5. The device as defined in claim 1 further including fill means carried by said housing for filling said reservoir with the beneficial agent.

6. The device as defined in claim 1 in which said housing is generally egg shaped and includes a base portion and a generally hemispherically shaped cover.

7. The device as defined in claim 1 in which said housing includes an internal chamber, said heat expandable means being disposed within said internal chamber, said housing including vent means for venting said internal chamber.

8. A device as defined in claim 7 in which said vent means comprises a vent passageway, said device further including vent control means carried by said housing for controlling flow through said vent passageway.

9. The device as defined in claim 7 further including means for introducing said heat expandable means into said housing.

10. A device for administering beneficial agents to a ruminant at a controlled rate said device being insertable into the rumen of the ruminant and comprising:

(a) a housing;

(b) a fill tube disposed with said housing, said fill tube having inlet and outlet ports;

(c) a distendable, elastomeric member for forming, in conjunction with said fill tube, a fluid reservoir in communication with said inlet and outlet ports of said fill tube, said elastomeric member being movable within said housing from a first position to a second position;

(d) heat expandable means disposed within said housing in proximity with said elastomeric member, said heat expandable means comprising a heat expandable gel, which, upon being heated, will act upon said elastomeric member to move said member toward said second position to cause fluid within said reservoir to flow outwardly of said outlet of said outlet ports of said fill tube; and

(e) delivery means in communication with said outlet of said fill tube for delivering the beneficial agent from said reservoir to the ruminant.

11. The device as defined in claim 10 further including a weight disposed within said housing, said weight being of a sufficient density to cause the housing to be retained within the rumen.

12. The device as defined in claim 10 further including fill means carried by said housing for filling said reservoir with the beneficial agent.

13. The device as defined in claim 10 in which said housing includes a base component having an interior chamber.

14. The device as defined in claim 13 further including means for introducing said heat expandable means into said interior chamber.

15. The device as defined in claim 13 in which said housing is generally egg shaped and includes a base assembly and a generally hemispherically shaped cover sealably connected to said base assembly.

16. The device as defined in claim 15 in which said base assembly comprises:

(a) a base component;

(b) a first manifold connected to said base component, said first manifold having both a fill passageway and a delivery passageway in communication with said fill tube; and

(c) a second manifold connected to said first manifold, said second manifold having a fill passageway in communication with said fill passageway of said first manifold and a delivery passageway in communication with said delivery passageway of said first manifold.

17. The device as defined in claim 16 further including connector means for connecting said cover to said second manifold.

18. The device as defined in claim 16 in which said base assembly includes vent means for venting said interior chamber to atmosphere.

19. The device as defined in claim 18 further including vent control means for controlling the flow of gases through said vent means.