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Flow immunosensor apparatus

  • US 6,245,296 B1
  • Filed: 03/31/1992
  • Issued: 06/12/2001
  • Est. Priority Date: 02/23/1990
  • Status: Expired due to Fees
First Claim
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1. A flow immunosensor for performing a real-time analysis of a sample which is to be analyzed and which is not yet present, said flow immunosensor consisting essentially of;

  • an exchanger including;

    a chamber having an inlet port for sample introduction and an outlet port, a support medium, comprising a bed having a volume of 0.1 to 0.5 ml, in the chamber, an antibody immobilized on the medium wherein the antibody recognizes with specificity and sensitivity a target, a labelled antigen complexed to said immobilized antibody and capable of being displaced by the target, said labelled antigen saturating the antigen-binding sites of said antibody;

    a detection apparatus connected to the exchanger via the outlet port; and

    a flow means adapted for flowing liquid through the bed at a rate of 0.1 to 2.0 ml/min, thereby providing a target molecule in said sample insufficient time in the vicinity of said antigen-binding site and said labelled antigen for equilibration.

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