×

Ratio-based decisions and the quantitative analysis of cDNA micro-array images

  • US 6,245,517 B1
  • Filed: 09/28/1999
  • Issued: 06/12/2001
  • Est. Priority Date: 09/29/1998
  • Status: Expired due to Term
First Claim
Patent Images

1. A method for analyzing gene expression in a cDNA micro-array image, the method comprising:

  • identifying target sites in the cDNA micro-array image, wherein the target sites are associated with a set of genes;

    computing a maximum-likelihood estimator for a coefficient of variation of expression level ratio samples, where the expression level ratio samples are taken from a collection of expression values for each gene in the set of genes associated with the target sites identified in the micro-array image, the expression level ratio samples indicate a ratio of an expression level for a first cell type to an expression level for a second cell type for a corresponding gene, and the expression levels for the corresponding gene are taken from a target site associated with the corresponding gene in the cDNA micro-array image;

    computing a confidence interval for the expression level ratio samples based on the maximum likelihood estimator for a coefficient of variation of expression level ratio samples; and

    identifying genes corresponding to expression level ratio samples outside the confidence interval.

View all claims
  • 0 Assignments
Timeline View
Assignment View
    ×
    ×