Methods of use for peroxynitrite decomposition catalysts, pharmaceutical compositions therefor
First Claim
1. A method of treating a medical condition which is advantageously affected by the accelerated decomposition of peroxynitrite in a subject having such condition comprising administering to the subject a metal complex which is a peroxynitrite decomposition catalyst.
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Abstract
The present invention provides a method for the treatment of diseases by the decomposition of peroxynitrite, preferably decomposition to benign products, comprising the use of a complex which is a selected ligand structure providing a complexed metal such as Mn, Fe, Ni and V transition metals. The method of use, as well as novel pharmaceutical compositions therefor, are for the treatment of diseases advantageously affected by decomposition of peroxynitrite ed at a rate over the natural background rate of decay of peroxynitrite in humans suffering from the disease which comprises administration of an amount of a complex, in dosage unit form, which is effective for such acceleration of the decomposition of peroxynitrite .
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22 Claims
- 1. A method of treating a medical condition which is advantageously affected by the accelerated decomposition of peroxynitrite in a subject having such condition comprising administering to the subject a metal complex which is a peroxynitrite decomposition catalyst.
- 10. A pharmaceutical composition in dosage unit form for the treatment of a disease in humans advantageously affected by decomposition of peroxynitrite at a rate over the natural background rate of decay of peroxynitrite in humans suffering from the disease comprising, per dosage unit, an amount of a metal complex effective for the decomposition of peroxynitrite.
Specification