Substituted aryl or heteroarylamides having retinoid-like biological activity
First Claim
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1. A compound of the formula whereinR1 is independently H or alkyl of 1 to 6 carbons;
- m is an integer having the value of 0-5;
p is an integer having the value of 0-2;
r is an integer having the value 0-2;
with the proviso that the sum of p and r is at least 1;
Z is O or S;
W is a substituent selected independently from the group consisting of F, Br, Cl, I, C1-6alkyl, fluoro substituted C1-6 alkyl, NO2, N3, OH, OCH2OCH3, OC1-10alkyl, tetrazol, CN, SO2C1-6-alkyl, SO2C1-6-fluoro substituted alkyl, SO—
C1-6 alkyl, CO—
C1-6alkyl, COOR8, phenyl, phenyl itself substituted with a W group other than with phenyl or substituted phenyl;
R8 is H, an alkyl group of 1 to 10 carbons or trimethylsilylalkyl where the alkyl group has 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons or a pharmaceutically acceptable salt of said compound.
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Abstract
Compounds of the formula
wherein the symbols have the meaning described in the specification, have retinoid-like biological activity.
101 Citations
3 Claims
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1. A compound of the formula
wherein R1 is independently H or alkyl of 1 to 6 carbons; -
m is an integer having the value of 0-5;
p is an integer having the value of 0-2;
r is an integer having the value 0-2;
with the proviso that the sum of p and r is at least 1;
Z is O or S;
W is a substituent selected independently from the group consisting of F, Br, Cl, I, C1-6alkyl, fluoro substituted C1-6 alkyl, NO2, N3, OH, OCH2OCH3, OC1-10alkyl, tetrazol, CN, SO2C1-6-alkyl, SO2C1-6-fluoro substituted alkyl, SO—
C1-6 alkyl, CO—
C1-6alkyl, COOR8, phenyl, phenyl itself substituted with a W group other than with phenyl or substituted phenyl;
R8 is H, an alkyl group of 1 to 10 carbons or trimethylsilylalkyl where the alkyl group has 1 to 10 carbons, or a cycloalkyl group of 5 to 10 carbons or a pharmaceutically acceptable salt of said compound. - View Dependent Claims (2, 3)
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Specification
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Current AssigneeAllergan, Inc. (Canada) (Abbvie Incorporated)
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Original AssigneeAllergan Sales LLC (Abbvie Incorporated)
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InventorsTeng, Min, Chandraratna, Roshantha A., Duong, Tien T.
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Primary Examiner(s)NORTHINGTON DAVIS, ZINNA
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Application NumberUS09/550,744Time in Patent Office421 DaysField of Search546/309, 514/352US Class Current514/352CPC Class CodesA61P 35/00 Antineoplastic agentsA61P 43/00 Drugs for specific purposes...C07C 233/81 having the nitrogen atom of...C07D 213/82 in position 3
